Perioperative Characteristics of Siblings Undergoing Liver or Kidney Transplant

Abstract

Objectives: Reasons for chronic liver and kidney failure may vary; sometimes more than 1 family member may be affected, and may require a transplant. The aim of this study was to examine the similarities or differences between the peri operative characteristics of siblings undergoing liver or kidney transplant.

Materials and Methods: The medical records of 6 pairs of siblings who underwent liver transplant and 4 pairs of siblings who underwent kidney transplant at Baskent University Hospital between 1989 and 2014 were retrospectively analyzed. Collected data included demographic features; comorbidities; reasons for liver and kidney failure; perioperative laboratory values; intraoperative hemodynamic parameters; use and volume of crystalloids, colloids, blood products, cell saver system, and albumin; duration of anesthesia; urine output; and postoperative follow-up data.

Results: The mean age of the 6 sibling pairs who underwent liver transplant was 16.3 +/- 12.2 years. All 12 patients had Child-Pugh grade B cirrhosis, with mean disease duration of 7.8 +/- 3.9 years. There were no significant differences between siblings with respect to intraoperative blood product transfusion, crystalloid and colloid fluid replacements, hypotension frequency, blood gas analyses, urinary output, duration of anhepatic phase, inotropic agent administration, post operative laboratory values, need for mechanical ventilation and vasopressors, occurrence of acute renal failure and infections, and duration intensive care unit stay (P>.05). The mean age of the 4 sibling pairs who underwent kidney transplant was 21.3 +/- 6.4 years, with mean duration of renal insufficiency of 2.2 +/- 1.6 years. There were no significant differences between siblings with respect to intraoperative crystalloid and colloid fluid administration, duration of anesthesia, intra operative mannitol and furosemide administration, and postoperative laboratory values (P>.05).

Conslusions: In conclusion, the 6 sibling pairs who underwent liver transplant and 4 sibling pairs who underwent kidney transplant in our cohort had similar perioperative characteristics.