Multiple Thrombotic Gene Mutations in Patients with Cerebral Venous Thrombosis: Three Case Reports and Literature Review

Abstract

Although cerebral venous thrombosis (CVT) is mostly seen in young adults, it is a disease that affects all age groups, has a broad range of symptoms, and usually carries a good prognosis. Extensive tests and examinations are needed to determine its etiology. Even in the presence of a marked risk factor, genetic thrombotic factors should be systematically investigated. Thrombotic gene mutations are among the most important hereditary causes of coagulation defects. Single gene mutations may be observed, as well as multiple gene mutations can rarely be detected. Here, we report three patients with cerebral venous thrombosis who had multiple gene mutations.