Başkent Üniversitesi Yayınları

Permanent URI for this communityhttps://hdl.handle.net/11727/13092

Browse

Filters

2008 - 20092

Settings

search.filters.applied.f.language: search.filters.language.en_USSubject: search.filters.subject.Complication

Search Results

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Procalcitonin and C-reactive Protein Serum Levels After Hematopoietic Stem-Cell Transplant
    (Başkent Üniversitesi, 2009-06) Azarpira, Negar; Daraie, Masumeh; Aghdaie, Mahdokht; Ramzi, Mani
    Objectives: Hematopoietic stem-cell transplant is a curative therapy for several malignant and nonmalignant disorders. The purpose of this study was to investigate the association of serum levels of high-sensitivity C-reactive protein and procalcitonin with complications such as acute graft-versus-host disease, veno-occlusive disease, and infection after hematopoietic stem-cell trans­plant. Materials and Methods: Serum high-sensitivity C-reactive protein and procalcitonin levels were sequentially measured with an enzyme-linked immunosorbent assay and a semiquantitative immunochromatographic assay in 35 patients who had undergone hematopoietic stem-cell trans­plant. Results: The high-sensitivity C-reactive protein serum level was increased in patients with acute graft-versus-host disease and in those with sepsis. Increased procalcitonin levels were associated only with bacterial infection. Only procalcitonin levels differentiated patients with infection from those with another transplant-related complication. Veno-occlusive disease did not alter C-reactive protein or procalcitonin levels. Conclusions: Our results support theories that serum levels of high-sensitivity C-reactive protein and procalcitonin are biomarkers for transplant-related complications such as graft-versus-host disease or infection and that the procalcitonin level can differentiate patients with infection from those with graft-versus-host disease.
  • No Thumbnail Available
    Item
    Serial Resistive Index and Pulsatility Index for Diagnosing Renal Complications in the Early Posttransplant Phase: Improving Diagnostic Efficacy by Considering Maximum Values
    (Başkent Üniversitesi, 2008-06) Radmehr, Ali; Shakiba, Madjid; Taheri, Amir Pejman Hashemi; Jandaghi, Ali Babaei
    Objectives: To present new approaches to using duplex Doppler scanning to detect kidney complications in the early posttransplant period. Materials and Methods: We assessed the resistive index and the pulsatility index in 127 renal transplant patients (73 men, mean age, 35.2 ± 14 years) who underwent duplex Doppler scanning on the first, third, and fifth days after transplant. Biopsies were performed in patients suspected of having graft dysfunction owing to clinical and laboratory findings. To differentiate complicated from healthy grafts, a receiver operating characteristic curve analysis was done, and an area under the curve was calculated for each variable. Results: In total, 47 grafts (37%) became complicated (40 rejections). The mean resistive index and mean pulsatility index were statistically significantly higher on the first, third, and fifth days after transplant in patients with complicated grafts than they were in patients with noncomplicated grafts (P < .0001). The mean resistive index and mean pulsatility index showed a significant rise from the first to the fifth day in patients with complicated grafts (P ≤ .014). The area under the curve of the receiver operating characteristic curve for resistive index and pulsatility index on successive days was statistically significant (P < .0001). The resistive index and the pulsatility index area under the curve were statistically significantly lower on the first day than they were on subsequent days. Considering the maximum value of a serially measured resistive index and pulsatility index (which were determined by comparing 3 measurements on the fifth day and selecting the highest one) as a new variable showed a better area under the curve compared with that calculated on the third day (P = .05 for resistive index; P = .012 for pulsatility index). Conclusions: The resistive index and the pulsatility index are effective means of diagnosing post­transplant renal complications. Including a serial assessment and considering the maximum values could improve the diagnostic efficacy on the fifth day after transplant.