Başkent Üniversitesi Yayınları

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Author: search.filters.author.Santiago J. SantelisSubject: search.filters.subject.Thermal injuries

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    Beyond Breastfeeding:Prolactin's Powers in Burn Wounds
    (Başkent Üniversitesi, 2023-03) Arnaldo Acosta; Matthew Araujo; Santiago J. Santelis
    ABSTRACT Burn injuries represent a significant health care challenge worldwide that requires effective interventions to optimize patient outcomes. Prolactin, a versatile hormone traditionally associated with lactation, has emerged as a promising factor with potential implications beyond its classical role. In this review article, we aim to synthesize and analyze the existing literature on the role of prolactin in burn injuries, focusing on its impact on inflammation, immune response, tissue repair, and potential neuroprotective effects. By exploring the mechanisms underlying prolactin's actions, this article provides insights into the therapeutic potential of prolactin in burn injury management.
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    The Endocrine Response to Burn Injuries: The Role of the Hypothalamic-Pituitary Hormones
    (Başkent Üniversitesi, 2022-03) Santiago J. Santelis
    ABSTRACT Burn injuries are one of the most common forms of trauma worldwide. Immediately after burn injury, marked emotional and physical responses occur, which are brought about by sudden increases in sympathetic nervous system activity and endogenous stress hormone levels. Hypermetabolism is a hallmark of the stress response to burns, and it is associated with poor clinical outcomes. The role of the endocrine system in this response is complex and important, and almost all hormones take part in it. Although endocrine studies in patients with burns started in the early 1950s, the exact role of the pituitary gland in these alterations is unknown, with the biochemical pathways so far poorly defined. The early recognition of these changes and their treatment can improve clinical outcomes. The aim of this review was to summarize the current knowledge on how the hypothalamic-pituitary hormones respond to thermal injuries.