Fakülteler / Faculties

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    Choroidal Thickness after Scleral Buckling Surgery versus Pars Plana Vitrectomy in Macula-Off Rhegmatogenous Retinal Detachment
    (2014) Akkoyun, I.; https://orcid.org/0000-0002-2860-7424; 24901425; AAK-7713-2021
    Purpose: Enhanced depth imaging (EDI) optical coherence tomography (OCT) provides high-definition cross-sectional images of the choroid. Information on alterations in choroidal thickness (CT) after scleral buckling surgery (SBS) and pars plana vitretomy (PPV) are rare. Methods: The medical charts of 44 patients (44 eyes) who underwent SBS versus PPV for macula-off rhegmatogenous retinal detachment (RRD) were retrospectively analysed. Patients with a follow-up >= 6 months were included. Postoperative EDI-OCT images concerning CT were evaluated 1 week, 1 month and 6 months postoperatively in 2 groups: group 1: cerclage + cryopexy + subretinal fluid drainage (SRD) + SF6 or air (n = 28 eyes), group 2: PPV + laser photocoagulation + C3F8. Subfoveal CT was compared between the groups and with the non-operated fellow eye. Results: Subfoveal CT in groups 1 and 2 was thicker 1 week postoperatively. There were no significant differences between the groups 2 or when comparing the operated eye with the fellow eye 1 and 6 months postoperatively. Conclusion: There were no differences in sub-foveal CT 1 and 6 months after SBS between the eye with macula-off RRD and the fellow eye. Thicker CT 1 week postoperatively after SBS may most likely be induced by scleral buckle reduced blood flow and increased haemostasis in the choroidal circulation and by scleral and choroidal inflammation after cryopexy versus laser photocoagulation after SBS versus PPV.
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    Relationship Between White Matter Hyperintensities and Retinal Nerve Fiber Layer, Choroid, and Ganglion Cell Layer Thickness in Migraine Patients
    (2018) Iyigundogdu, Ilkin; Derle, Eda; Asena, Leyla; Kural, Feride; Kibaroglu, Seda; Ocal, Ruhsen; Akkoyun, Imren; Can, Ufuk; 0000-0001-7860-040X; 0000-0003-2122-1016; 0000-0002-6848-203X; 0000-0002-4226-4034; 0000-0002-3964-268X; 0000-0002-2860-7424; 0000-0001-8689-417X; 28952336; AAJ-2053-2021; AAI-8830-2021; E-5914-2016; AAL-9808-2021; AAJ-2956-2021; V-3553-2017; AAK-7713-2021; AAJ-2999-2021
    Aim To compare the relationship between white matter hyperintensities (WMH) on brain magnetic resonance imaging and retinal nerve fiber layer (RNFL), choroid, and ganglion cell layer (GCL) thicknesses in migraine patients and healthy subjects. We also assessed the role of cerebral hypoperfusion in the formation of these WMH lesions. Methods We enrolled 35 migraine patients without WMH, 37 migraine patients with WMH, and 37 healthy control subjects examined in the Neurology outpatient clinic of our tertiary center from May to December 2015. RFNL, choroid, and GCL thicknesses were measured by optic coherence tomography. Results There were no differences in the RFNL, choroid, or GCL thicknesses between migraine patients with and without WMH (p>0.05). Choroid layer thicknesses were significantly lower in migraine patients compared to control subjects (p<0.05), while there were no differences in RFNL and GCL thicknesses (p>0.05). Conclusions The only cerebral hypoperfusion' theory was insufficient to explain the pathophysiology of WMH lesions in migraine patients. In addition, the thinning of the choroid thicknesses in migraine patients suggests a potential causative role for cerebral hypoperfusion and decreased perfusion pressure of the choroid layer.