Fakülteler / Faculties
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Item Serum Angiostatin Levels in Patients with Behcet's Disease: Does Angiogenesis Play A Role in The Pathogenesis of Behcet's Disease?(2014) Keskin, D.; Keskin, G.; Inal, A.; Ozisik, L.; https://orcid.org/0000-0002-0690-2529; 25012748; J-8056-2012Angiogenesis plays an important role in the pathogenesis of inflammatory diseases, but the possible role of angiogenesis in Behcet's disease (BD) has not yet been studied. The aim of this study was to determine angiostatin levels in patients with BD and the role of angiogenesis in the pathogenesis of the disease. Thirty-seven patients with BD (mean age: 28.6 +/- 5.4 years, mean disease duration: 9.3 +/- 3.7 years) and 18 healthy controls were enrolled to the study. Twenty-four patients were in active and 13 patients were in inactive stage of the disease. The mean serum angiostatin level of patients with BD was 113.9 +/- 653.2 and 60.7 +/- 20.1 ng/ml in healthy controls. The mean serum angiostatin level was 142.7 +/- 43.1 ng/ml in active and 86.9 +/- 15.5 ng/ml in inactive patients with BD. Serum angiostatin levels were significantly high in patients with BD compared with healthy controls (P<0.001) and it was significantly high in active patients compared with inactive patients with BD (P<0.001). In inactive patients with BD, serum angiostatin concentrations were found to be higher compared with healthy controls (P<0.01). In active BD patients, the mean serum angiostatin level was correlated with the deep vein thrombosis (r=0.482, P=0.05), uveitis (r=0.582, P=0.01), and arthritis (r=0.492, P=0.05). According to these results; elevated serum angiostatin levels in patients with BD suggest the possible role of angiogenesis in the pathogenesis of the disease and its high levels in inactive Behcet's patients is related with the continuous activation of the disease even in the subclinical period.Item High Levels of Endothelial Progenitor Cells Can Be Associated with Thrombosis in Patients with Behcet's Disease(2014) Bozkirli, E. D. E.; Keskek, S. O.; Kozanoglu, I.; Yucel, A. E.; https://orcid.org/0000-0002-5268-1210; https://orcid.org/0000-0002-4860-9072; 24774036; AAE-1241-2021Objective. Behcet's disease (BD) is a systemic disorder characterised by vasculitis. Endothelial progenitor cells are derived front the bone marrow and contribute to new vessel formation. The aim of this study was to investigate the level of endothelial progenitor cells in BD and BD-associated conditions. Methods. A total of 74 subjects were included in this study, of whom 44 and 30 subjects were patients with BD or healthy subjects, respectively. Endothelial progenitor cells were defined and measured by flow cytometry according to the expression of CD146, CD31 and CD34. We separated BD patients according to the active disease, pathergy test results, thrombosis and gender. MedCalc 12.5 software programme was used for statistical analyses. Results. The level of endothelial progenitor cells was comparable in patients with BD and healthy subjects (p=0.849). It was also comparable in patients with active or inactive BD (p=0.320). The level of endothelial progenitor cells was higher in patients with thrombosis (p=0.04). There was no statistical significant difference between pathergy positive and negative patients (p-=0.969). The level of endothelial progenitor cells was not correlated with age, C-reactive protein, erythrocyte sedimentation rate, white blood cells and disease duration (p>0.05). Conclusion. The level of endothelial progenitor cells was significantly higher in BD patients with thrombosis. On the other hand, they were not associated with disease activity, pathergy test and other conditions. EPCs may be a useful marker for thrombosis in patients with BD. In our opinion, this is the most expected result in this study.Item Behcet's Disease As A Causative Factor of Cerebral Venous Sinus Thrombosis: Subgroup Analysis of Data from The VENOST Study(2019) Goksel, Basak K.; https://orcid.org/0000-0003-2766-2277; 29992235; AAE-2609-2021Objective This study was performed to determine the rate of cerebral venous sinus thrombosis (CVST) among cases of Behcet's disease (BD) included in a multicentre study of cerebral venous sinus thrombosis (VENOST). Methods VENOST was a retrospective and prospective national multicentre observational study that included 1144 patients with CVST. The patients were classified according to aetiologic factors, time of CVST symptom onset, sinus involvement, treatment approach and prognosis. Results BD was shown to be a causative factor of CVST in 108 (9.4%) of 1144 patients. The mean age of patients in the BD group was 35.27 years and 68.5% were men, whereas in the non-BD CVST group, the mean age was 40.57 years and 28.3% were men (P < 0.001). Among the aetiologic factors for patients aged 18-36 years, BD was predominant for men, and puerperium was predominant for women. The onset of symptoms in the BD group was consistent with the subacute form. The transverse sinuses were the most common sites of thrombosis, followed by the superior sagittal sinuses. The most common symptom was headache (96.2%), followed by visual field defects (38%). Conclusions BD was found in 9.4% of patients in our VENOST series. Patients with BD were younger and showed a male predominance. The functional outcome of CVST in patients with BD was good; only 12% of patients presenting with cranial nerve involvement and altered consciousness at the beginning had a poor outcome (modified Rankin Score 2).Item Association of Disease Activity with Serum and Tear IL-2 Levels in Behc, et Disease(2016) Turkcuoglu, Peykan; Arat, Yonca Ozkan; Kan, Emrah; Kan, Elif Kilic; Chaudhry, Imtiaz A.; Koca, Suleyman; Celiker, Ulku; Ilhan, Nevin; https://orcid.org/0000-0002-6578-7444; 26110544; AAA-2259-2021Purpose: To investigate the association of Behcet disease activity with serum and tear interleukin-2 levels. Methods: The study was designed as a prospective case control study. The study population consisted of 45 patients with Behcet disease and 24 age and sex-matched healthy participants. Behcet disease patients were classified as active (24 patients) or inactive (21 patients) according to disease activity. Serum and tear interleukin-2 levels were determined using the enzyme-linked immunosorbent assay method. Results: The mean serum and tear interleukin-2 levels of the active disease, inactive disease, and control groups were 17.04 +/- 5.02 and 32.61 +/- 16.53 pg/mL; 15.20 +/- 4.68 and 29.61 +/- 8.30 pg/mL; and 14.22 +/- 4.18 and 28.89 +/- 8.73 pg/mL, respectively. There was no statistically significant difference between the groups with respect to all measured data. Conclusions: There was no significant difference in serum or tear IL-2 levels between Behcet patients and controls; there was no association of disease activity with serum and tear IL-2 levels.Item Investigating the Role of IL-33 in the Pathogenesis of Behcet's Disease(2017) Cerci, Pamir; Altiner, Seda; Inal, Ali; Kose, Kenan; Keskin, Goksal; Olmez, Umit; 0000-0002-0690-2529; 28412856; J-8056-2012Objectives: Behcet's disease (BD) is an inflammatory disease, characterized by oral aphthous lesions, recurrent uveitis, skin lesions, and genital ulcerations. Increased release of several cytokines may play a role in the inflammatory stages of BD. IL-33, a member of the IL-1 cytokine superfamily, plays an important role in inflammation. We analyzed serum IL-33 concentration in BD patients to assess its possible role in the pathophysiology of this disease. Methods: The study included 54 BD patients, 31 with active BD and 23 with inactive BD as well as 18 matched healthy controls. Serum IL-33 levels were measured using an enzyme-linked immunosorbent assay (ELISA). Results: The mean serum IL-33 levels were 4.84 +/- 2.81 pg/ml in the BD patients (6.16 +/- 2.94 pg/ml in the active stage and 2.86 +/- 0.54 pg/ml in the inactive stage) and 2.88 +/- 0.42 pg/ml in the healthy controls. Serum IL-33 levels were significantly higher in patients with BD compared with the healthy controls (p < 0.01). In active Behcet patients with arthritis the mean serum IL-33 level was higher but this finding was not statistically significant (p = 0.122). Conclusion: IL-33 may play a significant role of in the pathogenesis of BD.Item Behcet's Disease-Related Superior Vena Cava Syndrome and Bleeding Downhill Varices: A Rare Complication(2017) Yasar, Bulent; Kilicioglu, Gamze; 28467587Obstruction of the superior vena cava (SVC) due to any cause results in development of venous collaterals in the upper part of the esophagus, known as "downhill" varices. Although rare, bleeding can be life-threatening. Presently described is case of Behcet's disease-related SVC occlusion in a patient who presented with gastrointestinal bleeding from upper esophageal varices.Item Correlation Between IL-17A/F, IL-23, IL-35 and IL-12/-23 (P40) Levels in Peripheral Blood Lymphocyte Cultures and Disease Activity in Behcet's Patients(2018) Sonmez, Cemile; Yucel, Aysegul Atak; Yesil, Turan Hilmi; Kucuk, Hamit; Sezgin, Berna; Mercan, Ridvan; Yucel, Ahmet Eftal; Demirel, Gulderen Yanikkaya; https://orcid.org/0000-0002-4860-9072; 29557072Behcet's disease is a chronic multisystemic disease with remissions and relapses. Several studies have shown that immune mechanisms play an important role in the development of the disease. In order to assess the association of disease activity with IL-17A/F, IL-23, IL-12/23 (p40) and IL-35 expression, we aimed to investigate production of these cytokines in peripheral blood mononuclear cells (PBMCs) from Behcet's patients and normal controls. Furthermore, we included Systemic Lupus Erythematosus (SLE) as disease control to evaluate the specificity of our data for immunopathogenesis of BD. Totally 15 active, 15 inactive Behcet's patients, 12 active and 12 inactive SLE patients and 12 healthy volunteers were enrolled in the study. Peripheral blood mononuclear cells were separated, lymphocyte cultures were performed and IL-17A/F, IL-12/23 p(40), IL-23, IL-35 cytokine levels were measured by ELISA in culture supernatants in the presence or absence of phytohemagglutinin (PHA) on time-dependent manner. IL-17 A/F levels increased parallel to IL-23 levels in Behcet's and SLE patients. Compared to healthy controls, IL-17 A/F levels were higher in active Behcet's and SLE patients; on the contrary, levels of IL-35 were lower. IL-17A/F, IL-12/23 (p40) and IL-23 levels were detectable most frequently in active Behcet's patients followed by active SLE patients. Our results indicate that IL-17 A/F, IL-23 and IL-12/23 (p40) may play role in the immunopathogenesis of BD so as Th17 and Th1 cell responses. Since IL-35 levels were lower in active Behcet's patients compared to inactive patients and healthy controls, there may be a plasticity between Th17 and Treg cells according to the state of disease activity.Item Audiological and vestibular measurements in Behcet's disease(2019) Ertugrul, Ozlem; Mutlu, Ahmet; Zindanci, Ilkin; Cam, Osman Halit; Ozluoglu, Levent; 30929056; AAP-1533-2020IntroductionBehcet's disease (BD) is a vasculitis that involves all small vessels and influences the multiple systems of the human body. This study aimed to evaluate the audio-vestibular system involvement of patients with BD and healthy individuals.Materials and methodsThis study was designed as a prospective case-control blinded study. Thirty-one patients with BD and 31 healthy individuals were included. All the subjects were evaluated via pure tone audiometry (PTA), video head impulse test (vHIT), post head shake nystagmus test (PHSNT) and dizziness handicap inventory (DHI) to check for audio-vestibular system involvement.ResultsPatients with BD showed higher PTA scores in both speech and high frequencies. The vHIT revealed pathological saccades, particularly in horizontal canals (right ear: p=0.002, left ear: p=0.039). The gain values of the patients were slightly lower than those of the control group; however, gain and gain asymmetry differed significantly in a few canals. In the spontaneous nystagmus test and PHSNT, pathological nystagmus was detected to be significantly higher in the patient group than control group (p=0.001); but the saccade presence in vHIT and nystagmus in PHNT did not differ among the patients (p=0.106). In addition, the DHI scores of the patients group were higher than those of the control group (p<0.001). No correlation was found between disease duration and saccade presence.ConclusionThe vHIT was used preliminary for evaluating the vestibular system in BD. This study showed the influence of BD on the audio-vestibular system, in particular isolated horizontal canal involvement was discovered in patients with BD.Level of evidenceLevel III b.Item Isolated brachial artery aneurysm successfully treated with a covered stent in a patient with Behcet's disease(2019) Yigit, Gorkem; Ozen, Selin; Ozen, Anil; Iscan, Zafer; 32082926Behcet's disease is a vasculitic pathology characterized by skin lesions, genital ulcers, aphthous stomatitis, and uveitis. Arterial aneurysms are rare in this disease. Herein, we report a rare case of an isolated brachial artery aneurysm with a history of Behcet's disease treated with endovascular covered stenting of the brachial artery.Item Massive lower gastrointestinal bleeding associated with solitary rectal ulcer in a patient with Behcet's disease(2015) Bes, C.; Dagli, U.; Yilmaz, F.; Soy, M.; 26492967Solitary rectal ulcer syndrome is a rare benign disorder that has a wide range of clinical presentations and variable endoscopic findings which makes it difficult to diagnose and treat. The clinical and endoscopic picture in this condition can also mimic malign ulceration, malignancy or Crohn's disease. Behcet's disease can affect the gastrointestinal tract. However to the best of our knowledge, no case with solitary rectal ulceration has been reported so far in literature. We herein present a patient diagnosed with Behcet's disease admitted to our clinic with rectal bleeding due to solitary rectal ulceration.