Fakülteler / Faculties

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    Transplanted Kidney Function Evaluation
    (2014) Aktas, Ayse; https://orcid.org/0000-0003-0149-2265; 24484750; AAI-8772-2021
    The best option for the treatment of end-stage renal disease is kidney transplantation. Prompt diagnosis and management of early posttransplantation complications is of utmost importance for graft survival. Biochemical markers, allograft biopsies, and imaging modalities are used for the timely recognition and management of graft dysfunction. Among several other factors, improvements in imaging modalities have been regarded as one of the factors contributing to increased short-term graft survival. Each imaging procedure has its own unique contribution to the evaluation of renal transplant dysfunction. In the era of multimodality imaging and emerging clinical considerations for the improvement of graft survival, evaluating an imaging modality in its own right may not be relevant and may fall short of expectation. Recognized as being mainly a functional imaging procedure, radionuclide imaging provides valuable information on renal function that cannot be obtained with other imaging. modalities. For evaluating and establishing the current place, indications, and potential applications of radionuclide renal transplant imaging, a classification of renal allograft complications based on renal allograft dysfunction is essential. The major factor affecting long-term graft loss is chronic allograft nephropathy. Its association with early posttransplantation delayed graft function and repeated acute rejection episodes is well documented. Long-term graft survival rate have not improve significantly over the years. Imaging procedures are most commonly performed during the early period after transplantation. There seems to be a need for performing more frequent late posttransplantation imaging for the evaluation of acute allograft dysfunction, subclinical pathology, and chronic allograft changes; for understanding their contribution to patient management; and for identification of pathophysiological mechanisms leading to proteinuria and hypertension. With its unique advantage of relating perfusion to function, the potential for radionuclide imaging to replace late protocol biopsies needs to be investigated. (C) 2014 Elsevier Inc. All rights reserved.
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    Evaluation of choroidal thickness using enhanced depth imaging by spectral-domain optical coherence tomography in patients with pseudoexfoliation syndrome
    (2015) Eroglu, F.C.; Asena, L.; Simsek, C.; Kal, A.; Yilmaz, G.; 25853396
    Purpose To investigate the choroidal thickness using optical coherence tomography in the eyes of patients with unilateral and bilateral pseudoexfoliation syndrome and to compare them with healthy controls. Methods We studied four groups: (1) affected eyes from 30 patients with unilateral PEX syndrome affecting the right eye of 17 patients and the left eye of 13 patients; (2) clinically unaffected eyes of 30 patients with unilateral PEX syndrome; (3) the eyes of 30 patients with bilateral PEX syndrome; and (4) the eyes of 30 normal healthy subjects. Choroidal thickness was evaluated using high-speed, high-resolution enhanced depth imaging by spectral-domain optical coherence tomography. Optical coherence tomography features were compared in all groups using the statistical package SPSS v 15.0. Results The mean subfoveal choroidal thicknesses were 237.35 +/- 58.01 mu m in group 1; 330.75 +/- 47.84 mu m in group 2; 206.3 +/- 86.75 mu m in group 3; and 311.8 +/- 51.42 mu m in group 4. Significant differences in the mean subfoveal choroidal thickness were found between groups 1 and 2 (P < 0.001), groups 1 and 4 (P = 0.004), groups 2 and 3 (P < 0.001), and groups 3 and 4 (P < 0.001). Conclusion In this study, it was observed that clinically affected eyes of patients with PEX syndrome have significantly thinner choroids compared with the clinically unaffected eyes of patients with unilateral PEX syndrome and eyes of healthy controls.