Fakülteler / Faculties

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    Serum Vitamin D Levels Decrease in Children with Acute Urticaria
    (2016) Ozdemir, B.; Koksal, B. T.; Karakas, N. M.; Ozbek, O. Y.; 0000-0003-2974-9579; 0000-0003-4286-7086; 0000-0001-9580-7656; 27475773; HKW-0623-2023; AAJ-2034-2021; AAX-3831-2020; AAF-2109-2021
    Background: Acute urticaria is an immune-inflammatory disease, characterised by acute immune activation. There has been increasing evidence showing that vitamin D deficiency is associated with increased incidence and severity of immune-inflammatory disorders. Objective: The aim of this study was to evaluate serum vitamin D levels in acute urticaria. Methods: We enrolled 30 children with acute urticaria and 30 control subjects. Concentrations of 25-hydroxyvitamin D [25(OH)D], a biomarker of vitamin D status, were measured in serum of acute urticaria patients and compared with the control group. Results: There were no significant differences in baseline variables (age, gender, weight) between the groups. Vitamin D deficiency (<20 ng/ml) was significantly higher in patients with acute urticaria than in control patients. Serum 25(OH)D levels were significantly lower in the study group compared to those in the control group (13.1 +/- 4.3 vs 28.2 +/- 7.4 ng/mL, p<0.05). Moreover, we found negative correlation between mean duration of acute urticaria and serum vitamin D levels (p<0.01). Conclusion: This study revealed a significant association of lower serum 25(OH)D concentrations with acute urticaria and an inverse relationship with disease duration. These findings may open up the possibility of the clinical use of vitamin D as a contributing factor in the pathogenesis of acute urticaria and a predictive marker for disease activity in acute urticaria. A potential role of vitamin D in pathogenesis and additive therapy in acute urticaria needs to be examined. (C) 2016 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.
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    May rotavirus vaccine be affect food allergy prevalence?
    (2020) Karakas, Nazmi Mutlu; Arslan, Almina; Atalay, Ece; Ayli, Itir; Bagci, Zeynep Ilayda; Cesaretli, Sude; Koksal, Burcu Tahire; Yilmaz Ozbek, Ozlem; 0000-0002-2388-4158; 0000-0003-4286-7086; 0000-0001-9580-7656; 32530362; AAJ-7580-2021; AAX-3831-2020; AAF-2109-2021
    Incidence of food allergy (FA) during nursing period is 6-8% globally and It is reported %5,7 in Turkey. In our study, the aim is to determine whether the prevalence of food allergy (FA) increases in children vaccinated against rotavirus. The files of 681 infants who are still followed-up were retrospectively evaluated. Children who did not come to our clinic for all of their well-child follow-up visits were excluded from the study. Moreover, children diagnosed with allergy before vaccination and children with known gastrointestinal system disease were excluded from the study. The number of patients diagnosed with food allergy after being vaccinated against rotavirus was 12 (1.76%). Three children had a family history of allergy. Of 12 patients who were diagnosed after vaccination, 3 (n:104) were vaccinated with pentavalent vaccine and 9 (n:507) with monovalent vaccine. In the monovalent vaccination group, food allergy was found in 9 children (1.55%), and in the pentavalent vaccination group, food allergy was found in 3 children (2.88%). The difference between the two vaccination groups in terms of food allergy prevalence was not significant (p> .05). Although it is believed that food allergy, and even cow's milk protein allergy (CMPA) prevalence increases in infants vaccinated against rotavirus, in this study, no significant increase was observed in the prevalence of food allergy after rotavirus vaccination. Both types of vaccine had similar rates to each other.
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    Cutaneous allergic reaction due to alprazolam in a child
    (2016) Kutuk, Meryem Ozlem; Guler, Gulen; Guvenc, Ulas; Toros, Fevziye; Kaya, Tamer Irfan
    Cutaneous allergic reactions due to drug intake may be triggered by many types of drugs such as atropine, anticonvulsants and benzodiazepines. But allergic reactions due to benzodiazepines are extremely rare. Alprazolam is a benzodiazepine which may be useful for refractory idiopathic urticaria due to antihistaminergic effect. Although antihistaminergic effect of alprazolam, a cold urticaria case and an angioedema case induced by alprazolam are known in the literature. In the case, we present a child suffering from cutaneous allergic reaction due to alprazolam at the first dose taken.