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    Mitigating infusion-related reactions (IRRs) with cetirizine and montelukast in patients (pts) receiving REGN7075, an EGFRxCD28 bispecific antibody (bsAb)
    (Başkent Üniversitesi Tıp Fakültesi, 2025) Segal, N. H.; Girda, E.; Keenan, B. P.; Hecht, J. R.; Le, X.; Johnson, M. L.; Jimenez, J. Torres; Gomez-Roca, C. A.; Ghiringhelli, F.; Ates, O.; Garcia, V. Moreno; Laux, D.; Berz, D.; Chen, R.; Wang, J.; Han, H.; Mathias, M. D.; Seebach, F. A.; Kinnaman, M. D.; Sohal, D.
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    Identifying future risk factors of uncontrolled asthma control: the TAAR study perspective
    (Başkent Üniversitesi Tıp Fakültesi, 2025) Erdogan, Tuba; 41305966
    Objective: Risk factors associated with asthma symptom control is crucial for disease management. This study aimed to determine the risk factors of patients with uncontrolled asthma and to examine the relationship with their geographical patterns. Methods: This cross-sectional study was conducted at 36 centers across Turkey. Future risk factors (FRFs) such as exposure to triggers/allergens and inadequate or poor inhalation technique, etc., were identified based on the Global Initiative for Asthma (GINA) guidelines. The associations between FRFs and demographic and clinical characteristics, geographical regions, and levels of asthma control were analyzed. Results: The study included 2,053 adult asthma patients. At least one FRF was identified in 1576(76.8%) patients. The most common FRFs were exposure to allergens/triggers (n: 664; 32.3%), impaired asthma symptom control (n: 540; 26.3%), and eosinophilia (n: 526; 25.6%). Regarding regional differences, the most prevalent FRFs in the Marmara region were exposure to allergens/triggers and frequent use of short-acting beta-2 agonists (>3 boxes/year). In contrast, eosinophilia was more common in the Southeastern region, while inadequate or poor inhalation technique, noncompliance with treatment, and psychosocial or socioeconomic problems were more frequently observed in the Eastern Anatolia region. Asthma control was achieved in 79.5% of patients without any FRFs; however, this rate decreased significantly to 25% among patients with more than four FRFs. Conclusions: This study demonstrates that FRFs in asthma vary according to demographic and disease characteristics, as well as geographical distribution. An increased number of FRFs was associated with asthma control. However, an individualized approach remains essential for achieving optimal asthma management.
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    Transience and the Modern Turkish Interior
    (2023) Hasirci, Deniz; Ultav, Zeynep Tuna; Sumnu, Umut; AAC-5579-2020
    Despite the expansion of research in modern interiors around the world and a more inclusive dialogue with regards to geography, ultimately, the field is still lacking theory and methods derived from its own specific needs rather than being adapted from architectural research, and a focus on its transient nature that is likely to lead to more impactful research and preservation results. Modern Turkish interiors research have also expanded greatly with individual, as well as projects or research groups like docomomo_tr interiors and DATUMM (Documenting and Archiving Modern Turkish Furniture) that create awareness through various forms of scholarly (documentaries, archival work) and popular (public exhibitions, popular books and magazines, newspaper pieces, and films) interiors research and several struggles are common worldwide, socio-cultural and economic reasons result in a faster pace in Turkey, creating an urgency to implement innovative methods and approaches fitting contemporary prerequisites of the field.
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    The Power Bases in Multiplayer Video Games
    (2023) Omerbas, Ali Cagil
    This study deals with how players employ different power relations while playing videogames. Power is a difficult concept to define but it is usually explained with the ability to influence. Social psychologists John French and Bertram Raven's studies have defined five bases for social influence: coercive (based on punishment), referent (based on affection), reward (based on reward), expert (based on expertise) and legitimate (based on agreed regulations) powers. Many other studies have tested their theory in various fields, and it proved to be a lasting one. Researchers conducted studies in areas such as education, business, sports with this theory and obtained meaningful results. However, the power bases of video game players has never been studied, despite the fact that video game studies has already been established as an academic field -with many scholars discussing empowerment through games. This study focuses on measuring the power of a player over another one. There can be two types of such relations: it can either take place among players in an everybody-for-themselves kind of environment - which is called inter-power relations, or it can take place between the members of a team, working together for a common goal. This is called intra power relations. This study demonstrates that expert and reward powers are preferred in inter and intra-power relations, referent being another valid option for teamwork.
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    Intelligent Optimization Under the Makespan Constraint: Rapid Evaluation Mechanisms Based on the Critical Machine for the Distributed Flowshop Group Scheduling Problem
    (2023) Wang, Yuhang; Han, Yuyan; Wang, Yuting; Tasgetiren, M. Fatih; Li, Junqing; Gao, Kaizhou
    In the flowshop scheduling literature, the insertion-based neighborhood search method is often considered to obtain high-quality solutions. It will lead to expending extensive computational effort when evaluating the objective function. Rapid evaluation methods based on Taillard's acceleration can reduce the time complexity of function evaluation. However, existing rapid evaluation methods cannot be applied directly to the distributed flowshop group scheduling problem (DFGSP), especially to minimize the total tardiness time objective. Thus, we first proposed two theorems and their proofs based on the critical machine. Then, two rapid evaluation methods based on these theorems are proposed to accelerate the evaluation of the objective. Considering the multiple coupled sub-problems in the DFGSP, we proposed a cooperative iterated greedy algorithm (CIG) combining two rapid evaluation methods, in which intergroup and intra-group neighborhood search strategies are proposed to enhance the search depth and breadth. Comprehensive statistical experiments show that computational effort is extensively decreased in the calculation of total tardiness time, and the CIG algorithm significantly outperforms the eight compared algorithms.& COPY; 2023 Elsevier B.V. All rights reserved.
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    The Influence of Different Sugammadex Doses on Neural Tube Development in Early-Stage Chick Embryos
    (2023) Ayhan, Asude; Efe, Ekin; Fidan, Pinar A.; Efe, Oguzhan E.; Ates, Eylem Gul; Sahinturk, Fikret; Ayhan, Selim; 0000-0002-6166-2601; 0000-0001-6955-9839; 0000-0002-3243-7843; 0000-0003-3047-0305; 0000-0002-0471-3177; 37565787; HGE-9282-2022; AAJ-2057-2021; AAJ-4728-2021; W-7908-2019; ABG-5365-2020; AAI-7972-2021
    Background: Sugammadex is a modified gamma-cyclodextrin that has been developed with the goal of reversing the steroidal neuromuscular blocking agents. The aim of the present study is to investigate the effects of different sugammadex doses on embryologic and neural tube development in an early-stage chick embryo model. Methods: A total of 100 specific pathogen-free, fertilized domestic chicken eggs were randomly divided into five groups (n = 20, each), and placed in an automatic cycle incubator. The eggs in the "control (C)" group were incubated without administration of any drug till the end of the experiment. Subblastodermic administration of 0.9% NaCl as vehicle control (VC) and different doses of sugammadex solutions prepared with the latter [2 mg/mL (LD), 4 mg/mL (MD), 16 mg/mL (HD)] were performed at 30 hr of incubation. All embryos were removed from the eggs at 72 hr when they were expected to reach Hamburger-Hamilton (HH) stages 19-20, then they were fixed, and evaluated histo-morphologically. Results: Embryonic development was not observed in 11 eggs (1 in C, 1 in VC; 3 in LD, 3 in MD, and 3 in HD). All the developed embryos were compatible with the HH stages 19-20. A neural tube closure defect was detected in one embryo in the HD group. No statistically significant difference was found between the groups in terms of embryonic and neural tube developments. Conclusions: No significant association was found between the drug and adverse outcomes; however, a trend with dosing was seen. Further studies are required before conclude on safety and extrapolate these results to human beings.
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    Comment on: Intensity Modulated Radiotherapy in Head and Neck Cancer: Initial Experience of the First Treated Cases from North-East India
    (2023) Topkan, Erkan; Somay, Efsun; Selek, Ugur; 0000-0001-8251-6913; 38187854; AAG-2213-2021; O-5474-2014
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    The Effect of Acupressure Applied to Different Fistula Area on Fistule Needle Entry Pain
    (2023) Turgay, Gulay; Cevik, Banu; Inanoglu, Isilay; Kaya, Semiha; AAN-3284-2021
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    The Effect of Glomerular C3 Deposition on Renal Outcome in Patients with Membranous Nephropathy: Data of the Tsn-Gold Study
    (2023) Gursu, Meltem; Ceheci, Egemen; Turkmen, Aydin; Dervisoglu, Erkan; Sezen, Mehnet; Turgutalp, Kenan; Sahin, Gulizar Manga; Trablus, Sinan; Kutlay, Sim; Uzun, Sami; Ustundag, Sedat; Dursun, Belda; Ayli, Deniz; Tatar, Erhan; Oztop, Kenan Evren; Basturk, Taner; Cevher, Simal Koksal; Yilmaz, Zulfikar; Tunca, Onur; Sevinc, Mustafa; Yadigar, Serap; Duranay, Murat; Arikan, Izzet Hakki; Elciuglu, Omer Celal; Karakan, Sebnem; Turkmen, Kultigin; Torun, Dilek; Gungor, Ozkan; Artan, Ayse Serra; Ozturk, Savas; Unsal, Abdulkadir; Seyahi, Nurhan; AAD-9111-2021