Fakülteler / Faculties
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Item A Comprehensive Examination of UV-VIS Spectrophotometric Methods in Pharmaceutical Analysis Between 2015-2023(Başkent Üniversitesi Eczacılık Fakültesi, 2024-06) Enes, Duygu; Dastan, Kerem; Kaplan, Ozan; Celebier, Mustafa; Dogan, AysegulBackground: Quality control is a system of validated procedures in which many samples, including active pharmaceutical ingredients and final products, are analyzed using standard or validated analytical methods. Method: Analytical methods used in analyzing active pharmaceutical ingredients or final products in the pharmaceutical industry can be methods registered in pharmacopeias and developed by the company itself. For this reason, published papers related to pharmaceutical analysis attract analysts and researchers' attention. In this study, pharmaceutical analysis and bioanalysis studies carried out between 2015 and 2023 were examined using Google Scholar, and the recent trends were determined for pharmaceutical analysis. Among the published papers performing conventional analytical techniques for pharmaceutical analysis, those applying UV-VIS spectrophotometry method were selected to predict a future perspective in this study. In addition to the data obtained, the current situation of the pharmaceutical industry was considered to correlate with the obtained data for pharmaceutical analysis. Results: The results were presented with comparative tables and summarizing graphs. Interpreting the results allowed us to determine the trends that pharmaceutical analysis studies will lead in the future. This study can be helpful for researchers working on pharmaceutical analysis in both the industry and academia to predict future trends in pharmaceutical analysis. As a result of the literature research covering the dates 2015-2023, 56% of UV-VIS Spectrophotometric methods are used on pharmaceutical dosage forms, 27% are bulk, 16% are pure, 2% are biological materials, and 0.4% are herbal. Made from materials. Of these studies, 28% were conducted in the 200-240 nm range, 27% were conducted in the 240-300 nm range, and only 44% were conducted at >300 nm. Interpreting the results allowed us to determine the trends that pharmaceutical analysis studies will lead in the future. Conclusion: This study can be helpful for researchers working on pharmaceutical analysis in both the industry and academy side to predict future trends for pharmaceutical analysis.Item Voices from the Field: What Do Turkish Students Suggest? A Socio-Ecological Study on School Belonging(Başkent Üniversitesi Eğitim Bilimleri Fakültesi, 2024-04-29) Akbaba Altun, Sadegul; Turan Bora, HaticeThe study of school belonging has become increasingly important as the sense of belonging to school is a source of motivation that influences students' behaviour. This study aims to explore students' views on what society, principals, teachers, guidance counsellors, families and students should do to increase students' sense of school belonging. The study is a basic qualitative research. Eight hundred and seventy-six high school students from T & uuml;rkiye were asked to answer open ended questions about what school stakeholders should do to ensure that students feel a sense of belonging to school. This study found some different results compared to previous studies by revealing the expected behaviour of stakeholders outside the school, such as society and family. Belonging to school is highly complex and linked to some of society's most challenging problems and therefore needs to be examined within the school and its environment. For this reason, the research findings on what stakeholders should do to increase school belonging are presented within the framework of the socio-ecological systems model.Item Ceftobiprole Mono-Therapy Versus Combination Or Non-Combination Regimen Of Standard Antibiotics For The Treatment Of Complicated Infections: A Systematic Review And Meta-Analysis(Başkent Üniversitesi Eczacılık Fakültesi, 2024-06-10) Jame, Wissal; Basgut, Bilgen; Abdi, AbdikarimObjective: Various bacteria produce complicated infections that are difficult to treat worldwide. Ceftobiprole is effective against resistant Gram-positive and Gram-negative bacteria. Methods: This review assessed effectiveness and safety of ceftobiprole monotherapy for severe infections. A systematic review and meta-analysis of randomized controlled trials comparing clinical cure, microbiological cure, and safety of ceftobiprole alone to a combination or non-combination antibiotic regimen was conducted. Until December 20, 2022, we searched a major databases. Results: This study includes 4168 patients from six trials. Ceftobiprole and comparator-received patients had similar clinical responses for all patient population. Also, the eradication rate of all organisms and specific pathogenic bacteria in microbiologically examined patients was comparable between the groups. Ceftobiprole induced more gastrointestinal side events than comparable drugs, mostly nausea [OR 1.91 (1.26-2.90), p = < 0.01]. While skin-related adverse events were significantly associated with comparator antibiotics [6 trials, 4062 patients; OR 0.77 (0.60-0.99), p=0.03]. Conclusion: Ceftobiprole monotherapy is effective and safe for severe infections caused by Gram-positive or Gram-negative bacteria.Item Is The Repair Bond Strength Affected When Substrate And Repair Composite Are Not Of The Same Kind? A Systematic Review And Meta-Analysis: Effect Of Repair Composite On Repair Bond Strength(Başkent Üniversitesi Diş Hekimliği Fakültesi, 2024-03-21) Kose, Leyla Kerimova; Isik, Hatice; Eyuboglu, Tan Firat; Ozcan, Mutlu; Cehreli, Sevi Burcak; Arhun, NeslihanThe aim was to evaluate the influence of repair resin type on repair bond strength in the direct resin restorations through a systematic review. Electronic databases MEDLINE via PubMed, Web of Science, Scopus, BBO, and LILACS were searched, and the reference lists of relevant studies were further hand-searched. A total of 15,709 articles that were browsed yielding to a final of five studies were included in meta-analysis. Analyses were performed using R software with the 'metafor' package, with standardized mean differences employed. A multi-level meta-analysis was conducted utilizing restricted maximum-likelihood estimates (p <= .05). In the shear bond strength group, significant heterogeneity was observed (Q = 50.274, p < .0001), whereas no significant heterogeneity was detected in the microtensile bond strength group (Q = 5.102, p = .4063). Separate analyses of both shear bond strength and microtensile bond strength groups showed no statistically significant differences between dissimilar and similar materials (p > .05). Egger's regression indicated no evidence of publication bias in either group. Sensitivity analyses revealed statistically insignificant pooled effect sizes for shear bond strength. In the microtensile group, one study influenced the results when excluded from the analysis. It could be suggested that the repair of composite resin with the same kind of resin composite is not mandatory.Item Is The Repair Bond Strength Affected When Substrate And Repair Composite Are Not Of The Same Kind? A Systematic Review And Meta-Analysis: Effect Of Repair Composite On Repair Bond Strength(Başkent Üniversitesi Diş Hekimliği Fakültesi, 2024-03-21) Kose, Leyla Kerimova; Isik, Hatice; Eyuboglu, Tan Firat; Ozcan, Mutlu; Cehreli, Sevi Burcak; Arhun, NeslihanThe aim was to evaluate the influence of repair resin type on repair bond strength in the direct resin restorations through a systematic review. Electronic databases MEDLINE via PubMed, Web of Science, Scopus, BBO, and LILACS were searched, and the reference lists of relevant studies were further hand-searched. A total of 15,709 articles that were browsed yielding to a final of five studies were included in meta-analysis. Analyses were performed using R software with the 'metafor' package, with standardized mean differences employed. A multi-level meta-analysis was conducted utilizing restricted maximum-likelihood estimates (p <= .05). In the shear bond strength group, significant heterogeneity was observed (Q = 50.274, p < .0001), whereas no significant heterogeneity was detected in the microtensile bond strength group (Q = 5.102, p = .4063). Separate analyses of both shear bond strength and microtensile bond strength groups showed no statistically significant differences between dissimilar and similar materials (p > .05). Egger's regression indicated no evidence of publication bias in either group. Sensitivity analyses revealed statistically insignificant pooled effect sizes for shear bond strength. In the microtensile group, one study influenced the results when excluded from the analysis. It could be suggested that the repair of composite resin with the same kind of resin composite is not mandatory.Item Use Of Advanced Measurement And Reality Technologies In Cultural Heritage Sites From The Perspective Of Technology And Tourism(Başkent Üniversitesi Ticari Bilimler Fakültesi, 2024-03-12) Varol, Fatih; Oksuz, MerveIn recent years, in parallel with technological innovations, the use of modern techniques instead of traditional methods has become widespread in studies on archiving, preserving, restoring and visiting cultural heritage (CH) in the digital environment. Reality technologies, advanced measurement methods in engineering and mobile applications have brought a multidisciplinary perspective to the subject of sustainability of CH sites and visiting them within the scope of tourism. This study investigates the contribution of studies carried out with the latest technological opportunities in CH areas to sustainability and tourism activities. It reveals with the most concrete examples how the fastest LIDAR (Light Detection and Ranging) technology used in remote sensing of concrete objects, as well as close range photogrammetry and unmanned aerial vehicle (UAV) photogrammetry applications can be integrated into the sustainability of CH and reality technologies. The three-dimensional (3D) images obtained in this way have enabled world-famous ancient cities, museums, natural and archaeological sites to be visited virtually with the help of augmented reality (AR), virtual reality (VR) and mixed reality (MR) applications. These methods also provide significant advantages in terms of time and cost compared to traditional technologies in the digital documentation of CH and VR studies.Item Exploring The Viability Of Alternative Cooling-Lubrication Strategies İn Machining Processes: A Comprehensive Review On The Performance And Sustainability Assessment(Başkent Üniversitesi Mühendislik Fakültesi, 2024-02-19) Roy, Soumikh; Das, Anshuman; Kumar, Ramanuj; Das, Sudhansu Ranjan; Rafighi, Mohammad; Sharma, PriyaranjanThis paper explores the challenges of machining difficult-to-cut metals using tools like coated carbide, ceramics, and CBN under dry conditions, addressing issues such as heat generation, tool wear and friction, chip evacuation, surface integrity, vibration, and chatter. Though cutting fluids have historically improved machinability, environmental concerns, such as toxicity and non-biodegradability, are significant. Researchers aim to enhance the economic and ecological aspects of machining by reducing cutting fluid usage. This paper provides an overview of the performance assessment and sustainability evaluation of various cooling and lubrication methods during the machining of hard-to-machine as well as difficult-to-cut metals. Additionally, the literature review highlights various environmentally friendly cooling strategies, such as minimum quantity lubrication (MQL) and cryogenic arrangements. According to the results of this review, the utilization of various cooling and lubrication technologies has the potential to enhance both sustainability and machinability properties while prolonging the lifespan of cutting tools. The findings also show that there is a lot of room for improvement in terms of optimizing and making these cooling-lubrication solutions more practical and effective.Item Hedda Gabler(2015) Raw, LaurenceItem Language and Literacy Development in Bilingual Settings(2018) Gezer, Melike Unal; 0000-0002-1598-9611; G-6126-2018Item Burnout among Turkish Physicians: A Systematic Review(2021) Toktamis, Aydin; Akkucuk, M. Husamettin; https://orcid.org/0000-0003-4569-1143; https://orcid.org/0000-0001-8126-9228; AAJ-2828-2021; AAE-3687-2021Introduction and objectives: By evaluating systematically and collectively studies examining burnout and accompanying factors of physicians in Turkey. we aimed to obtain a meta-perspective of the relevant reader or researcher. Material and Methods: English and in Turkish databases (Pub Med, Google Scholar, Ulakbim) were searched by using key words of physician, burnout and Turkey to identify Turkish physician burnout studies that have been published. Results: The databases search resulted in finding of forty-nine articles most of which were regional and only seven representing the nationwide perspective. A total of 12,598 physicians were evaluated in the surveys. The calculated mean values, supposedly roughly representing the total universe evaluated in all studies. were 18.3 for emotional exhaustion (EE), 7.9 for depersonalisation (DP) and 20.1 for personal accomplishment (PA), respectively. Conclusion: There is a low level of EE, DP and a high decrease in the sense of PA in physicians working in Turkey. The overall burnout experienced by them is not very high, but also is not very low. Female physicians appear to be at higher risk for EE sub-dimension and the risk of burnout is reduced with increasing age or experience.