Fakülteler / Faculties
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Item Is The Repair Bond Strength Affected When Substrate And Repair Composite Are Not Of The Same Kind? A Systematic Review And Meta-Analysis: Effect Of Repair Composite On Repair Bond Strength(Başkent Üniversitesi Diş Hekimliği Fakültesi, 2024-03-21) Kose, Leyla Kerimova; Isik, Hatice; Eyuboglu, Tan Firat; Ozcan, Mutlu; Cehreli, Sevi Burcak; Arhun, NeslihanThe aim was to evaluate the influence of repair resin type on repair bond strength in the direct resin restorations through a systematic review. Electronic databases MEDLINE via PubMed, Web of Science, Scopus, BBO, and LILACS were searched, and the reference lists of relevant studies were further hand-searched. A total of 15,709 articles that were browsed yielding to a final of five studies were included in meta-analysis. Analyses were performed using R software with the 'metafor' package, with standardized mean differences employed. A multi-level meta-analysis was conducted utilizing restricted maximum-likelihood estimates (p <= .05). In the shear bond strength group, significant heterogeneity was observed (Q = 50.274, p < .0001), whereas no significant heterogeneity was detected in the microtensile bond strength group (Q = 5.102, p = .4063). Separate analyses of both shear bond strength and microtensile bond strength groups showed no statistically significant differences between dissimilar and similar materials (p > .05). Egger's regression indicated no evidence of publication bias in either group. Sensitivity analyses revealed statistically insignificant pooled effect sizes for shear bond strength. In the microtensile group, one study influenced the results when excluded from the analysis. It could be suggested that the repair of composite resin with the same kind of resin composite is not mandatory.Item Use Of Advanced Measurement And Reality Technologies In Cultural Heritage Sites From The Perspective Of Technology And Tourism(Başkent Üniversitesi Ticari Bilimler Fakültesi, 2024-03-12) Varol, Fatih; Oksuz, MerveIn recent years, in parallel with technological innovations, the use of modern techniques instead of traditional methods has become widespread in studies on archiving, preserving, restoring and visiting cultural heritage (CH) in the digital environment. Reality technologies, advanced measurement methods in engineering and mobile applications have brought a multidisciplinary perspective to the subject of sustainability of CH sites and visiting them within the scope of tourism. This study investigates the contribution of studies carried out with the latest technological opportunities in CH areas to sustainability and tourism activities. It reveals with the most concrete examples how the fastest LIDAR (Light Detection and Ranging) technology used in remote sensing of concrete objects, as well as close range photogrammetry and unmanned aerial vehicle (UAV) photogrammetry applications can be integrated into the sustainability of CH and reality technologies. The three-dimensional (3D) images obtained in this way have enabled world-famous ancient cities, museums, natural and archaeological sites to be visited virtually with the help of augmented reality (AR), virtual reality (VR) and mixed reality (MR) applications. These methods also provide significant advantages in terms of time and cost compared to traditional technologies in the digital documentation of CH and VR studies.Item Exploring The Viability Of Alternative Cooling-Lubrication Strategies İn Machining Processes: A Comprehensive Review On The Performance And Sustainability Assessment(Başkent Üniversitesi Mühendislik Fakültesi, 2024-02-19) Roy, Soumikh; Das, Anshuman; Kumar, Ramanuj; Das, Sudhansu Ranjan; Rafighi, Mohammad; Sharma, PriyaranjanThis paper explores the challenges of machining difficult-to-cut metals using tools like coated carbide, ceramics, and CBN under dry conditions, addressing issues such as heat generation, tool wear and friction, chip evacuation, surface integrity, vibration, and chatter. Though cutting fluids have historically improved machinability, environmental concerns, such as toxicity and non-biodegradability, are significant. Researchers aim to enhance the economic and ecological aspects of machining by reducing cutting fluid usage. This paper provides an overview of the performance assessment and sustainability evaluation of various cooling and lubrication methods during the machining of hard-to-machine as well as difficult-to-cut metals. Additionally, the literature review highlights various environmentally friendly cooling strategies, such as minimum quantity lubrication (MQL) and cryogenic arrangements. According to the results of this review, the utilization of various cooling and lubrication technologies has the potential to enhance both sustainability and machinability properties while prolonging the lifespan of cutting tools. The findings also show that there is a lot of room for improvement in terms of optimizing and making these cooling-lubrication solutions more practical and effective.Item Hedda Gabler(2015) Raw, LaurenceItem Language and Literacy Development in Bilingual Settings(2018) Gezer, Melike Unal; 0000-0002-1598-9611; G-6126-2018Item Burnout among Turkish Physicians: A Systematic Review(2021) Toktamis, Aydin; Akkucuk, M. Husamettin; https://orcid.org/0000-0003-4569-1143; https://orcid.org/0000-0001-8126-9228; AAJ-2828-2021; AAE-3687-2021Introduction and objectives: By evaluating systematically and collectively studies examining burnout and accompanying factors of physicians in Turkey. we aimed to obtain a meta-perspective of the relevant reader or researcher. Material and Methods: English and in Turkish databases (Pub Med, Google Scholar, Ulakbim) were searched by using key words of physician, burnout and Turkey to identify Turkish physician burnout studies that have been published. Results: The databases search resulted in finding of forty-nine articles most of which were regional and only seven representing the nationwide perspective. A total of 12,598 physicians were evaluated in the surveys. The calculated mean values, supposedly roughly representing the total universe evaluated in all studies. were 18.3 for emotional exhaustion (EE), 7.9 for depersonalisation (DP) and 20.1 for personal accomplishment (PA), respectively. Conclusion: There is a low level of EE, DP and a high decrease in the sense of PA in physicians working in Turkey. The overall burnout experienced by them is not very high, but also is not very low. Female physicians appear to be at higher risk for EE sub-dimension and the risk of burnout is reduced with increasing age or experience.Item The Use of Fundus Autofluorescence in Dry Age-Related Macular Degeneration(2021) Keskek, Nadime Sahinoglu; Sermet, Figen; 0000-0001-8544-103X; 34187152; T-4258-2017Fundus autofluorescence (FAF) has been a well-known imaging method for quite some time. However, with developing technologies and novel imaging devices, FAF is being used more often to diagnose and monitor retinal diseases. The density of lipofuscin (LF) and other fluorophores in the retina have a determining role in FAF images. In dry age-related macular degeneration (AMD), hyperautofluorescence is seen in cases of increasing LF in the retina pigment epithelium, whereas hypoautofluorescence is detected in decreasing LF resulting from geographic atrophy. In recent years, studies have shown that FAF images provide prognostic information in patients with AMD. This review aims to highlight the importance of FAF imaging in dry AMD.Item Vestibular Illusions and Alterations in Aerospace Environment(2021) Demir, Abdurrahman Engin; Aydin, Erdinc; 0000-0001-6864-7378; 34386801; AAJ-2379-2021As the aerospace industry has grown rapidly over the years, aviators and astronauts have been exposed to some abnormal physiological changes arising from the dynamics of the aerospace environment. The vestibular system, encoding linear and angular movements of the head, is one of the main affected systems in which those abnormal changes can occur during flight. Despite the intricate and solid organization, vestibular units are such delicate structures that they can easily be deceived by aerial dynamics and gravity changes. Therefore, it is of vital importance for the continuity of flight safety to be aware of the detrimental alterations and impairments regarding the vestibular system and its reflex pathways. The aim of this paper was to present a review about how a healthy vestibular system is negatively affected within the aerospace environment and how some vestibular disorders become exaggerated or impaired during aviation and space activities.Item The Role of miRNA in Endometriosis(2021) Bilgili, Gamze; Verdi, Hasibe; Zeyneloglu, B. Hulusi; Tohma, Y. Aytac; Atac, F. BelginEndometriosis is characterized by the presence of endometrial gland and stroma outside of the endometrial cavity. Not only the complex nature of disease limits the identification of the pathogenic mechanisms of endometriosis but the lack of simple diagnostic procedure is the major limitation. So identification of a simple clinical tool for the diagnosis of endometriosis has become a high priority research objective. MicroRNAs (miRNAs), a class of small noncoding RNA molecules, have been recognized as key post- transcriptional regulators those may associate with endometriosis. In the present paper, we aimed to review the studies which focused on the prognosis and diagnosis of the endometriosis and miRNAs. As studies on the role of miRNAs in the pathogenesis of endometriosis increase in the literature, new ideas can be put forward for early diagnosis, prevention and treatment of the endometriosis.Item Efficacy and safety of novel glycopeptides versus vancomycin for the treatment of gram-positive bacterial infections including methicillin resistant Staphylococcus aureus: A systematic review and meta-analysis(2021) Jame, Wissal; Basgut, Bilgen; Abdi, Abdikarim; 34843561Objective To compare between current evidence of novel glycopeptides against vancomycin for the treatment of gram-positive bacterial infections. Methodology A systematic review and meta-analysis was done. Major databases were searched for eligible randomized control trials that assessed clinical success, microbiological success and safety profile of novel glycopeptides versus vancomycin for infections caused by gram-positive bacteria. Results This meta-analysis included eleven trials (7289 participants) comparing telavancin, dalbavancin and oritavancin with vancomycin. No differences were detected between novel glycopeptides and vancomycin for the treatment of skin and soft tissue infections (SSTIs) among modified intent-to-treat patients (OR: 1.04, CI: 0.92-1.17) as well as within the clinically evaluable patients (OR: 1.09, CI: 0.91-1.30). Data analysed from SSTIs, HAP and bacteremia studies on telavancin showed insignificant high clinical response in microbiologically evaluable patients infected with methicillin resistant Staphylococcus aureus (MRSA) (OR: 1.57, CI: 0.94-2.62, p: 0.08) and in the eradication of MRSA (OR: 1.39, CI: 0.99-1.96, P:0.06). Dalbavancin was non-inferior to vancomycin for the treatment of osteomyelitis in a phase II trial, while it was superior to vancomycin for the treatment of bacteremia in a phase II trial. Data analysed from all trials showed similar rates of all-cause mortality between compared antibiotics groups (OR: 0.67, CI: 0.11-4.03). Telavancin was significantly related with higher adverse events (OR: 1.24, CI: 1.07-1.44, P: <0.01) while dalbavancin and oritavancin were associated with significant fewer adverse events (OR: 0.73, CI: 0.57-0.94, p: 0.01; OR: 0.72, CI: 0.59-0.89, p: <0.01 respectively). Conclusion Efficacy and safety profiles of both dalbavancin and oritavancin were the same as vancomycin in the treatment of gram-positive bacterial infections in different clinical settings, while telavancin might be an effective alternative to vancomycin in MRSA infections, but caution is required during its clinical use due to the high risk of adverse events, especially nephrotoxicity.