Fakülteler / Faculties
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Item The Effect of Ginkgo Biloba on Anxiety and Oxidative Stress Parameters in Healthy Young Rats(2023) Arnous, Elif Azra; Yigit, Ayse ArzuItem Effects of Creative Arts Intervention on Anxiety, Depression and Sleep Quality Among Bone Marrow Transplantation Patients During Protective Isolation(2023) Sertbas, Gulcin; Ok, Elif; Unver, Vesile; https://orcid.org/0000-0003-4342-4965; 35583995; HGT-8047-2022BackgroundProtective isolation remains part of the standard of care for patients undergoing hematopoietic stem cell transplant in many places of the world. The consequences of protective isolation include increased anxiety and depressive symptoms.ObjectiveThe aim of this study was to determine the effects of creative interventions performed during the protective isolation period on anxiety, depression symptoms, and sleep quality of patients who underwent bone marrow transplantation (BMT).Interventions/MethodsThis study was a randomized, controlled, pre-post pilot design. A total of 20 patients made up the sample group. Participants were randomly assigned to the experimental (n = 9) or control group (n = 11). Hospital Anxiety and Depression Scale was applied to patients on the first day of admission to the unit and on the day of discharge. Questions prepared by researchers on sleep quantity and quality were administered every day during the patients' hospitalization. The patients in the experimental group carried out creative arts intervention for a total of 60 minutes a day, 3 to 4 days a week, while they were in the unit.ResultsThere was no difference in depression, anxiety, and sleep quality scores between the groups after intervention. However, depression and anxiety scores significantly decreased after the intervention in the experimental group, and sleep quality scores improved significantly.ConclusionCreative arts intervention may be beneficial for anxiety, depression, and sleep problems among patients undergoing BMT.Implications for PracticeCreative arts intervention is effective in coping with anxiety, depression, and sleep problems that patients may experience due to social isolation during the BMT process.Item The Effect of Different Information Sources on The Anxiety Level of Pregnant Women Who Underwent Invasive Prenatal Testing(2016) Cakar, Mehmet; Kasnakoglu, Berna Tari; Okem, Zeynep Guldem; Okuducu, Ummuhan; Beksac, M. Sinan; 26867089Objective: The goal is to explore the effects of age, education, obstetric history and information sources on the (Beck) anxiety levels of pregnant women attending invasive prenatal testing.Methods: Questionnaire results from 152 pregnant women are utilized. Results are analyzed through an independent samples t-test and a two-step cluster analysis attempting to categorize patients in terms of the chosen variables.Results: t-Tests reveal that age, education and bad obstetric history do not significantly affect anxiety levels. Descriptive statistics indicate that almost 60% of patients feel anxious mostly because of the fear of receiving bad news, followed by the fear of miscarriage, the fear of pain and the fear of hurting the baby. According to the cluster analysis, patients who use doctors or nurses as information sources have significantly lower anxiety levels, while those who do not receive information from any source have the second lowest level of anxiety. Patients who receive information from personal sources (i.e. friends and family) have the highest level of anxiety. Anxiety levels do not change according to test type.Conclusions: Doctors and nurses should allocate enough time for providing information about prenatal diagnosis before the procedure. This will reduce the anxiety level as well as the felt necessity to search for information from other sources, such as personal or popular which will further increase the level of anxiety.Item Factors Affecting Risk of Anxiety and Depression Among Diabetic and Hypertensive Patients Who Refer to Family Health Centers(2018) Emre, Nilufer; Topal, Kenan; Edirne, Tamer; Gereklioglu, CigdemThis cross-sectional study was carried out to investigate the factors which influence risk of anxiety and depression among diabetic and hypertensive patients who refer to family health centers. The Hospital Anxiety and Depression Scale (HADS) was applied for assessment of emotional status of the patients and the Hypertension Compliance Assessment Scale (HCAS) was applied for assessment of adherence to anti-hypertensive therapy. Of a total of 380 patients, 170 had hypertension (HT), 83 had type 2 diabetes mellitus (T2DM), and 127 had both HT and T2DM. According to HADS, 18.7% of the patients had risk of anxiety, 24.7% had risk of depression, and 12.6% had both risk of anxiety and depression. Mean HAD-Anxiety (HADS-A) score and HADS-Depression (HADS-D) score were significantly lower in the patients who had an adequate compliance to medication therapy (5.1 +/- 4.1 and 3.8 +/- 3.4, respectively) compared to the patients who had a low compliance to therapy (7.6 +/- 4.3 and 5.8 +/- 4.0, respectively) according to the Hypertension Compliance Assessment Scale ((2)=15.26, p<0.01 and (2)=13.80, p<0.01). Mean HADS-D score was found significantly lower among the diabetic patients with good glycemic control (3.7 +/- 2.9) compared to the patients with poor glycemic control (4.5 +/- 3.7) ((2)=25.00, p<0.05). Anxiety and depression are among the most frequent disorders as hypertension and diabetes in primary care setting. We revealed that risk of anxiety and/or depression was greater among hypertensive and diabetic patients, consistently with the previous studies. Our study also revealed that this condition negatively affected treatment compliance in hypertensive patients and glycemic control in diabetic patients.Item Cognitive Distortions in Patients with Social Anxiety Disorder: Comparison of A Clinical Group and Healthy Controls(2018) Kuru, E.; Safak, Y.; Ozdemir, I.; Tulaci, R. G.; Ozdel, K.; Ozkula, N. G.; Orsel, S.; 0000-0003-1949-4007; 0000-0002-3196-5089; 0000-0002-3531-3280; 0000-0002-3712-9444; 0000-0003-0184-7038; AAL-5207-2021; AAD-9366-2019; AAN-1111-2020; HTN-1754-2023; H-3307-2013; U-9276-2019Background and objective: Based on the cognitive model of social anxiety disorder (SAD), individuals who are anxious in social environments have some dysfunctional thoughts and beliefs regarding themselves and ways of others to judge their behaviors. A fundamental component of cognitive behavioral therapy is about noticing and changing cognitive distortions. The aims of our study were to analyze the differences in cognitive distortions between patients with SAD and a healthy control group, and examine the relationship between cognitive distortions and levels of anxiety and depression in patients with SAD. Methods: One hundred two individuals from two samples, non-clinical and clinical with SAD, were included. Patients were evaluated using a socio-demographic data form, the Liebowitz Social Anxiety Scale, Cognitive Distortions Scale (CDS), State-Trait Anxiety Inventory, and Beck Depression Inventory after a diagnostic interview. Results: There were significant differences between the patient and control group in terms of total CDS; most cognitive distortions were significantly higher in the patient group compared with the controls. The correlations between social anxiety, state and trait anxiety levels, depressive symptoms, and cognitive distortions were analyzed and significant correlations were found between the scales with a range of 0.316-0.676. Conclusions: Patients with SAD had more cognitive distortions compared with the healthy controls. The comorbid depressive symptoms in SAD had effects on 'mental filter, overgeneralization and personalization' in social situations, and there was no specific cognitive distortion without depression. Cognitive distortions in these patients were more related to depression and trait anxiety levels than the severity of social anxiety. (c) 2017 Asociacion Universitaria de Zaragoza para el Progreso de la Psiquiatria y la Salud Mental. Published by Elsevier Espana, S.L.U. All rights reserved.Item Anxiety, Depression, and Anger in Functional Gastrointestinal Disorders: A Cross-Sectional Observational Study(2018) Cakmak, Berna Bulut; Ozkula, Guler; Isikli, Sedat; Goncuoglu, Ibrahim Ozkan; Ocal, Serkan; Altinoz, Ali Ercan; Takintuna, Nilgun; 0000-0003-3719-9482; 0000-0003-2233-2105; 30103181; E-7929-2013; ABH-4817-2020; J-4811-2014Previous studies have identified a link between anger and somatization. However, little is known about the associations between anger and the development and progression of Functional Gastrointestinal Disorders (FGID). The study aim was to determine the associations between FGID and anger, anxiety, and depression. Participants in this cross-sectional observational study were 109 consecutive patients aged 18-64 years with FGID at Gastroenterology Clinic of Baskent University Hospital. A control group comprised of 96 individuals with no chronic gastrointestinal disorders recruited via snowball sampling. Sociodemographic and clinical information were obtained and participants completed the Hospital Anxiety and Depression Scale and the State-Trait Anger Expression Inventory-2. FGID participants scored higher than controls on depression, anxiety, state anger, and anger expression-in. When the FGID group was divided into upper and lower gastrointestinal symptom groups, the lower symptom group showed higher anger expression-out scores than the upper symptom group. Anger may contribute to the etiology and development of FGID. This is the first study to demonstrate a significant psychological difference between individuals with lower and upper FGID. Interdisciplinary collaboration with gastroenterologists and psychiatrists could strengthen FGID evaluation and may improve treatment compliance.Item Effect of rosuvastatin on spatial learning, memory, and anxiety-like behaviour in ovariectomized rats(2022) Emre-Aydingoz, Selda; Lux, Karl Michael; Efe, Oguzhan Ekin; Topcu, Deniz Ilhan; Erdem, Saban Remzi; 0000-0001-7823-7620; 0000-0002-3243-7843; 0000-0002-1219-6368; 35993621; ABA-4291-2020; W-7908-2019; E-3717-2019The effect of rosuvastatin (Ros) on cognitive function and anxiety-like behaviour in ovariectomized rats were evaluated. Eighteen female Wistar rats (218-310g, 6-8 months old) were allocated into sham (n = 6), ovariectomy (Ovx, n = 6) or Ovx + Ros (up to eighth week n = 6, then n = 4) groups. Ros was administered at 20 mg/kg/day by oral gavage for 12 weeks. Behavioural tests were performed at 4, 8 and 12 weeks following Ovx. At 12weeks, Ovx group had significantly longer escape latency than the sham group at the first day of the four-day training period of the Morris Water Maze test (p < .01). In the Elevated Plus Maze test, Ovx group spent significantly more time in the closed arms than the sham group (p < .01), and this anxiety-like behavioural effect of Ovx was prevented by 12-weeks Ros treatment (p < .05). In conclusion, Ros prevents memory deficit and anxiety-like behaviour in the ovariectomized rats, a model for human surgical menopause.Item Evaluation of Electrodermal Activity and Anxiety Behaviors in Diabetic Rats Given Vildagliptin and Metformin(2022) Shawesh, Muftah; Alshareef, Mohammed; Boyuk, Gulbahar; Yigit, Ayse Arzu; Dolu, NazanItem The Effects of High Dose Vitamin D and Zinc on Anxiety and Exploratory Activity in Rats(2022) Baroud, Amna Abdulsalam; Dolu, NazanItem The relationship between pain and clinical parameters, depression, anxiety and sleep quality in patients with spinal injury(2022) Balikci, Sibel; Bardak, Ayse NurObjective: To examine the frequency of pain in individuals with spinal cord injury, and to assess the relationship of pain with functional status, sleep quality, anxiety and depression levels. Method: The prospective, cross-sectional study was conducted from March to June 2018 at Istanbul Physical Medicine and Rehabilitation Training and Research Hospital, Istanbul, Turkey, and comprised adult patients of wither gender with spinal cord injury who were in the rehabilitation phase both on outpatient and inpatient basis. Data was collected using a questionnaire exploring demographic and clinical features. The presence of pain was assessed using the Leeds Assessment of Neuropathic Symptoms and Signs scale and, in case pain was found present, it was categorised as neuropathic, nociceptive and mixed type pain types. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index, while the Hospital Anxiety and Depression scale was used to evaluate anxiety and depression levels. Data was analysed using SPSS 20.Results: Of the 150 patients, 104(69.3%) were males and 46(30.7%) were females. The median age of the sample was 46 (IQR:20.52) years. Neuropathic pain was observed in 61(40.7%) patients, nociceptive in 32(21.3%) and mixed type in 12(8%). Depression was found in 71(47.3%) patients, poor sleep quality in 41(27.3%) and anxiety in 35(23.3%). Sleep, anxiety and depression scores were higher in the presence of neuropathic and nociceptive pain (p<0.05). Conclusion: Pain is a common complication in patients with spinal cord injury. In the presence of pain, sleep quality is worse, and anxiety and depression levels are high.