Fakülteler / Faculties
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Item Novel Scalp Flap Elevation With Balloon Trocar Dissection Device(2023) Ozkan, Burak; Savran, Suleyman; Uysal, Cagri A.; 37470710Background:Balloon trocar devices have been utilized in several surgical cases to reach a difficult-to-access location, achieve hemostasis, and obtain safe, efficient surgery.Objective:Highlight the balloon trocar dissection device in a novel technique of scalp flap elevation for tissue expander placement.Methods:The pocket for the tissue expander was determined at the scalp. A 2 cm vertical incision was made. A 12 mm balloon trocar is then introduced and insufflated. Through the trocar, endoscopic light is then inserted. Scalp flap elevation was performed with the device. The exact location of the pocket was seen with the lumination of endoscopic light.Results:The balloon trocar dissection device provides easy scalp flap elevation and bleeding control. With the help of endoscopic light, the pocket for the expander was created precisely.Conclusion:The balloon trocar device is simple, effective, low-cost equipment for tissue expander placement in the scalp.Item Giant Basal Cell Carcinoma Causing Axillary Contracture: A Case Report of an Unusual Localization of an Advanced Case(2023) Albayati, Abbas; Ozkan, Burak; Tepeoglu, Merih; Uysal, Cagri A.; 0000-0003-2806-3006; 0000-0003-3093-8369; 0000-0001-6236-0050; 38061706; AAC-3344-2021Basal cell carcinoma (BCC) is the most common type of non-melanoma skin cancer. Although BCC arises most commonly in sun-exposed areas of the body, such as the head and neck, it infrequently can be seen in sun-protected parts as well. Axilla is one of the least encountered areas of BCC. Delay in the diagnosis or management alongside negligence of the patient can lead to a tumor reaching a giant size. We report a case of giant axillary BCC in a 59-years old female patient with no known risk factors for skin cancers. The tumor was excised with wide margins, and the tissue defect was reconstructed with latissimus dorsi musculocutaneous flap. A 3-year follow-up did not show any sign of recurrence or metastasis.Item Effect of Mesenchymal Stem Cells on Skin Graft to Flap Prefabrication: Reply(2015) Uysal, Cagri A.; 0000-0001-6236-0050; 25668502Item Asymmetric Z-plasty for Telephone Deformity in Prominent Ear Correction(2014) Uysal, Afsin; Uysal, Cagri A.; Cologlu, Harun; Borman, Huseyin; https://orcid.org/0000-0001-6236-0050; https://orcid.org/0000-0002-8605-9032; 25098579; AAJ-2949-2021There have been plenty of surgical techniques for the correction of prominent ears. "Telephone deformity" or "reverse telephone ear" has been described as the undesired result of the inappropriate correction of the prominent ear, mainly the deficient correction of the lobule. We have performed an asymmetric Z-plasty to the lobule to overcome this deformity not only by excision of the excess skin but also by transposition of the soft tissue. Between 2005 and 2011, the technique currently described was performed in 19 patients. Preoperative, intraoperative, and postoperative standardized photographs were taken, and measurements were done on postoperative first week, first month, and first year. The measurements include ear height at 3 different horizontal planes as follows: (1) the most cranial point of the ear, (2) the middle point of the ear, and (3) the most caudal point of the ear. The angle between the vertical plane of the head and the ear was measured at these previously defined 3 points. These measurements were used for indication and preoperative planning. There were statistically significant differences between preoperative and postoperative values (P < 0.05). The postoperative first year results indicated the effectiveness of this alternative technique for the long-term maintenance of the position of the lobule.Item The Effect of Adipose Derived Stromal Vascular Fraction on Stasis Zone in An Experimental Burn Model(2018) Eyuboglu, Atilla Adnan; Uysal, Cagri A.; Ozgun, Gonca; Coskun, Erhan; Ertas, Nilgun Markal; Haberal, Mehmet; 0000-0002-3462-7632; 0000-0001-6236-0050; 0000-0002-9805-9830; 29032969; AAJ-8097-2021; AAJ-2949-2021; IQW-7940-2023Background: Stasis zone is the surrounding area of the coagulation zone which is an important part determining the extent of the necrosis in burn patients. In our study we aim to salvage the stasis zone by injecting adipose derived stromal vascular fraction (ADSVF). Methods: Thermal injury was applied on dorsum of Sprague-Dawley rats (n=20) by the "comb burn" model as described previously. When the burn injury was established on Sprague-Dawley rats (30min); rat dorsum was separated into 2 equal parts consisting of 4 burn zones (3 stasis zone) on each pair. ADSVF cells harvested from inguinal fat pads of Sprague-Dawley rats (n=5) were injected on the right side while same amount of phosphate buffered saline (PBS) injected on the left side of the same animal. One week later, average vital tissue on the statis zone was determined by macroscopy, angiography and microscopy. Vascular density, inflammatory cell density, gradient of fibrosis and epithelial thickness were determined via immunohistochemical assay. Results: Macroscopic stasis zone tissue viability (32 + 3.28%, 57 + 4.28%) (p<0.01), average number of vessels (10.28 +/- 1.28, 19.43 +/- 1.72) (p<0.01), capillary count (15.67 +/- 1.97, 25.35 +/- 2.15) (p<0.01) vascular density (1.55 +/- 0.38, 2.14 +/- 0.45) (p<0.01) epithelial thickness (0.014 +/- 0.009mm, 0.024 +/- 0.0011mm) were higher on ADSVF side. Fibrosis gradient (1.87 +/- 0.51, 1.50 +/- 0.43) (p<0.01) and inflammatory cell density (1.33 +/- 0.40, 1.20 +/- 0.32) (p<0.01) were higher on the PBS side. Conclusion: Macroscopic and microscopic findings determined that ADSVF has a statistically significant benefit for salvaging stasis zone on acute burn injuries. (c) 2017 Elsevier Ltd and ISBI. All rights reserved.Item Effectiveness of Bone Marrow Stromal Cell Sheets in Maintaining Random-Pattern Skin Flaps in an Experimental Animal Model(2016) Uysal, Cagri A.; 0000-0001-6236-0050; 27070212; AAJ-2949-2021Item The effect of adipose stromal vascular fraction on transverse rectus abdominis musculocutaneous flap: an experimental study(2016) Ataman, Murat Gorkem; Uysal, Cagri A.; Ertas, Nilgun Markal; Bayraktar, Nilufer; Terzi, Aysen; Borman, Huseyin; 0000-0002-7886-3688; 0000-0001-6236-0050; 0000-0002-1225-1320; 27010192; Y-8758-2018; AAJ-2949-2021; F-7546-2013Item Adipose-Derived Stem Cells Enhance Axonal Regeneration through Cross-Facial Nerve Grafting in a Rat Model of Facial Paralysis(2016) Abbas, Ozan L.; Borman, Huseyin; Uysal, Cagri A.; Gonen, Zeynep B.; Aydin, Leyla; Helvacioglu, Fatma; Ilhan, Sebnem; Yazici, Ayse C.; https://orcid.org/0000-0001-6236-0050; https://orcid.org/0000-0002-6026-0045; https://orcid.org/0000-0002-3132-242X; 27465163; AAJ-2949-2021; AAH-8887-2021; AAS-6810-2021Background: Cross-face nerve grafting combined with functional muscle transplantation has become the standard in reconstructing an emotionally controlled smile in complete irreversible facial palsy. However, the efficacy of this procedure depends on the ability of regenerating axons to breach two nerve coaptations and reinnervate endplates in denervated muscle. The current study tested the hypothesis that adipose-derived stem cells would enhance axonal regeneration through a cross-facial nerve graft and thereby enhance recovery of the facial nerve function. Methods: Twelve rats underwent transection of the right facial nerve, and cross-facial nerve grafting using the sciatic nerve as an interpositional graft, with coaptations to the ipsilateral and contralateral buccal branches, was carried out. Rats were divided equally into two groups: a grafted but nontreated control group and a grafted and adipose-derived stem cell-treated group. Three months after surgery, biometric and electrophysiologic assessments of vibrissae movements were performed. Histologically, the spectra of fiber density, myelin sheath thickness, fiber diameter, and g ratio of the nerve were analyzed. Immunohistochemical staining was performed for the evaluation of acetylcholine in the neuromuscular junctions. Results: The data from the biometric and electrophysiologic analysis of vibrissae movements, immunohistochemical analysis, and histologic assessment of the nerve showed that adipose-derived stem cells significantly enhanced axonal regeneration through the graft. Conclusion: These observations suggest that adipose-derived stem cells could be a clinically translatable route toward new methods to enhance recovery after cross-facial nerve grafting.Item Platelet-Rich Plasma Increases Pigmentation(2017) Uysal, Cagri A.; Ertas, Nilgun Markal; 0000-0001-6236-0050; 27438442; AAJ-2949-2021Platelet-rich plasma (PRP) is an autologous solution of plasma containing 4 to 7 times the baseline concentration of human platelets. Platelet-rich plasma has been widely popular in facial rejuvenation to attenuate wrinkles and has been practically used. The authors have been encountering various patients of increased hiperpigmentation following PRP applications that were performed to attenuate the postinflammatory hiperpigmentation especially after laser treatment. The authors have been using PRP for facial rejuvenation in selected patients and in 1 patient the authors have encountered increased pigmentation over the pigmented skin lesions that were present before the application. The authors recommend that the PRP might increase pigmentation especially in the face region and precautions might be taken before and after the application. Platelet-rich plasma should not be used for the treatment of post inflammatory hiperpigmentation.
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