Fakülteler / Faculties

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Author: search.filters.author.Ulusoy, Mahmut Oguz

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    Evaluation of Retrobulbar Blood Flow and Choroidal Thickness in Patients with Rheumatoid Arthritis
    (2018) Kal, Ali; Duman, Enes; Sezenoz, Almila Sariguel; Ulusoy, Mahmut Oguz; Kal, Oznur; https://orcid.org/0000-0001-7544-5790; https://orcid.org/0000-0002-7030-5454; https://orcid.org/0000-0002-7751-4961; 28730400; AAJ-4936-2021; AAJ-4860-2021; AAJ-7586-2021
    PurposeTo evaluate whether retrobulbar blood flow and choroidal thickness (CT) are affected in patients with rheumatoid arthritis (RA), and the relationship between these values.MethodsWe evaluated 40 eyes of 20 RA patients and 40 eyes of 20 healthy controls. The enhanced depth imaging optical coherence tomography, color Doppler imaging, was held. Statistical analysis was performed.ResultsPeak systolic velocity (PSV) of ophthalmic (OA) and central retinal artery (CRA) were significantly higher in RA. No significant difference was observed when end-diastolic velocity (EDV) of OA and CRA was compared between the groups. The resistivity index (RI) of OA and CRA was higher in RA. Perifoveal/subfoveal CT was lower in RA. Negative correlation was detected between the RI of OA and the perifoveal CT, and a positive correlation was detected between RI of CRA and CT.ConclusionsOcular hemodynamics is effected by RA and can exaggerate ocular complications of various vascular diseases such as diabetes mellitus, hypertension, retinal vascular occlusions.
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    Effect of Fingolimod (FTY720) on Choroidal Thickness in Patients with Multiple Sclerosis
    (2017) Kal, Ali; Ulusoy, Mahmut Oguz; Horasanli, Bahriye; Cezairlioglu, Sefik; Kal, Oznur; 0000-0002-7751-4961; 0000-0001-7544-5790; 0000-0003-3142-1011; 28619430; AAJ-7586-2021; AAJ-4936-2021
    Objective: Using spectral domain optical coherence tomography (SD-OCT), to compare the choroidal thickness in a healthy population (group 1), with newly diagnosed multiple sclerosis (MS) patients (group 2), with MS patients who underwent beta-interferon monotherapy (group 3) and MS patients who underwent fingolimod therapy for 1 year (group 4) Methods: Twenty-five control subjects (25 eyes), 24 newly diagnosed (24 eyes) MS patients, 22 MS patients who underwent fingolimod monotherapy for 1 year (22 eyes), and 24 MS patients who underwent beta-interferon monotherapy for 1 year (24 eyes) were included in this study. The control group consisted of age- and gender matched healthy individuals. The choroidal thickness measurements were performed using a high-speed and high-resolution SD-OCT device. The choroidal thickness measurements were compared using a One Way Anova and Post-Hoc Tukey test. Results: Ninety-five eyes of 95 participants were included in this study. The mean age of the control group was 27.83 +/- 4.60, and it was 26.83 +/- 6.79, 27.87 +/- 6. 46 and 27.58 +/- 6.65 in the newly diagnosed MS group, fingolimod group and beta-interferon group, respectively. In fingolimod group N-1000, N-1500 and T-1500 was significantly lower than control group. (p = 0.026, p = 0.06 p = 0.13) Conclusion: Choroidal thickness values at N-1000, N-1500 and T-1500 levels in fingolimod group were found lower than in control but higher than in newly diagnosed MS group. This result can be explained with the therapeutic effect of the fingolimod on MS.
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    Are Diabetic Patients Aware of The Danger in Turkey?
    (2016) Ulusoy, Mahmut Oguz; Kivanc, Sertac Argun; Atakan, Mehmet; Uzun, Ozgur; Ozturk-Sahin, Bilge; Olcaysu, Osman Okan; Karatepe, Arzu Seyhan; Zorlu-Ozturk, Sibel; Turker, Ibrahim
    Purpose: The aim of this study is to assess the awareness of the diabetic retinopathy and the level of the diabetic retinopathy in the diabetic patients, which consulted to the state hospitals in Turkey. Methods: A total of 1071 patients, admitted to 8 different state hospitals' ophthalmology clinics around the country, were included to this cross sectional multicentred study. All diabetic patients were asked to respond specifically prepared questionnaire including diabetic retinopathy and diabetes mellitus and underwent fundus examination to assess the diabetic retinopathy level. Results: The mean age of the study population was 57.5 years and the 57.4 % of the patients were women. 34.7% of the patients' were responded "NO" to the question of "Are you aware of the eye complications of diabetes mellitus?". The study also showed that 200 of 699 patients (28.6%) who aware of the diabetic retinopathy, despite having this information do not have regular eye examination for the diabetic retinopathy. It was seen that even 40.62% (26/64) of the college graduates don't go regular checks. The majority of the aware patients (40.5 %) pointed out that they took information from internal medicine or endocrinologists and the 28.1% of the patients were informed from elsewhere (family, neighbor, TV, etc.). Conclusion: One third of the subjects monitored were not aware of diabetic retinopathy. It is noteworthy to emphasize the importance of the routine eye examination for preventing vision loss, regardless of the educational level. The warning of the physicians through written and visual media is thought to be effective in preventing irreversible condition of this disease.
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    Contamination of Eyedrops Used for Diagnostic Purposes in Outpatients Clinics: Are We Aware?
    (2017) Kivanc, Sertac Argun; Budak, Berna Akova; Ulusoy, Mahmut Oguz; Guler, Burcin; Yucel, Ahmet Ali; Kivanc, Merih
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    Evaluation of Dry Eye Using Anterior Segment Optical Coherence Tomography in Patients With End-Stage Renal Disease Undergoing Hemodialysis
    (2018) Kal, Oznur; Ulusoy, Mahmut Oguz; Kal, Ali; Tanriaski, Gulsah; Cezairlioglu, Sefik; https://orcid.org/0000-0002-7751-4961; https://orcid.org/0000-0001-7544-5790; 29205873; AAJ-7586-2021; AAJ-4936-2021
    The aim of the present study was to evaluate dry eye parameters with conventional tests and tear meniscus with Anterior Segment Optical Coherence Tomography (AS-OCT) in patients with end-stage renal disease (ESRD). Thirty-eight ESRD patients undergoing hemodialysis, and 40 healthy individuals were enrolled. An ocular surface disease index questionnaire (OSDI) was administered. Before conventional dry eye tests, tear meniscus were evaluated using AS-OCT. After a complete ocular examination, Schirmer and break-up time (BUT) tests were performed and probable corneal staining was investigated. Schirmer test and BUT values were significantly lower in ESRD patients (P<0.05). OSDI scores and corneal staining scores were significantly higher in ESRD patients (P<0.05). Tear meniscus height, tear meniscus depth, and tear meniscus area, which were obtained by AS-OCT were significantly lower in patients with ESRD (P<0.05). Tear meniscus evaluation using AS-OCT is an effective and non-invasive method to assess tear meniscus in patients with ESRD. Patients with ESRD undergoing hemodialysis should obtain regular ophthalmic examination, especially for dry eye.
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    Investigation of Corneal Biomechanics at Moderate to High Refractive Errors
    (2018) Inceoglu, Nehir; Emre, Sinan; Ulusoy, Mahmut Oguz; 28540493; T-5643-2019
    Corneal hysteresis (CH) and corneal resistance factor (CRF) are corneal biomechanical parameters which were measured by ocular response analyzer (ORA). Aim of this study was to define the CH and CRF in high myopic and hyperopic patients and compare the results with emmetropic control group. A total of 193 eyes of 100 healthy volunteers were included. Study groups were high myopic patients (n = 27) with spherical refractive errors (SRE) of greater than -5.00D, high hyperopic patients (n = 20) with SRE of greater than +3.00D and controls (n = 53) with SRE between +/- 1.00D. All subjects underwent IOP and corneal biomechanical evaluation with the ORA. Also Goldmann applanation tonometry (GAT), central corneal thickness (CCT), corneal curvature and axial length measurements were taken. Mean age of groups was 30.7 +/- 6.9, 29.1 +/- 7.7, 28.9 +/- 5.6 years (p > 0.05). Among study groups except CRF and CCT, all parameters were significantly different between study groups. CH was lowest in the high myopic group and highest in the high hyperopia. In all groups, there were significant correlations between CH and CRF, CCT, SRE, SE (spherical equivalent), AL (axial length) and between CRF and CCT. GAT and IOPg (Goldmann-correlated intraocular pressure) measurements were significantly correlated with CCT (p < 0.05). One of the major findings was as the CH approaches 11.2 mmHg, IOPcc (corneal-compensated intraocular pressure) and IOPg get close to each other. The results revealed that CRF is not affected by refractive errors and IOPcc is not affected by any other ocular parameter. The difference between IOPcc and IOPg was greatest in myopic group, and IOP (intraocular pressure) measurement in these patients deserves high suspicion.
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    Comparison of The Effects of Anti-Vascular Endothelial Growth Factor Treatments on Pigment Epithelial Detachment in Age-Related Macular Degeneration
    (2021) Ulusoy, Mahmut Oguz; Kal, Ali; Yilmaz, Gursel; 0000-0001-7544-5790; 0000-0002-2589-7294; 33481151; AAJ-4936-2021; AAK-6987-2021
    Purpose The aim of this study is to compare structural and visual outcomes of naive neovascular age-related macular degeneration patients with significant pigment epithelial detachment (PED), treated with ranibizumab and aflibercept. Methods This was a retrospective case series that included 33 naive patients treated with ranibizumab and 25 with aflibercept. The patients were followed with pro re nata (PRN) after first three intravitreal injections. LogMAR visual acuity, PED height and radius on spectral domain optical coherence tomography findings were compared. Results Baseline mean PED height was 270.39 +/- 114.14 mu m and 315.24 +/- 115.8 mu m (p = 0.14); baseline mean PED radius was 2063.64 +/- 942.75 mu m and 1958.88 +/- 452.22 mu m (p = 0.61); and baseline BCVA was 1.16 +/- 0.73 and 1.09 +/- 0.69 (p = 0.73), for ranibizumab, and aflibercept group, respectively. In aflibercept group, there was statistically significant decrease in PED height at first, third and 12th months. In PED radius, decrease was greater in aflibercept group, however not significant. In addition, in aflibercept group visual acuity was better at all three months; however, none of them were significant. Conclusion Although the maximum improvement was seen at third month, final visual acuity and parameters of PED were better in aflibercept group. The efficacy of the both drug to choroidal neovascularization was known; however, in cases with significant PED, aflibercept can be consider for the first-level treatment.
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    Influence of Different Antidepressants on Ocular Surface in Patients With Major Depressive Disorder
    (2021) Isik Ulusoy, Selen; Ulusoy, Mahmut Oguz; 33347023
    Purpose Several studies have previously reported the association between dry eye and depression along with the treatment of depression. The aim of this study was to investigate the effects of different antidepressant drugs on tear parameters in patients with major depressive disorder. Methods We recruited 132 patients who were using different antidepressants and 58 healthy controls. Venlafaxine, duloxetine, escitalopram, and sertraline were used by 34, 28, 36, and 34 patients, respectively. The participants filled out and completed the Beck Depression Scale. We recorded Schirmer test, tear breakup time (TBUT) and corneal staining values of the participants. The Ocular Surface Disease Index was completed by the participants. In addition, we evaluated the tear meniscus parameters by using anterior segment optical coherence tomography. Results All conventional dry eye tests and tear meniscus parameters were significantly lesser in the depression group than in the control group (Schirmer test, 11.41 +/- 6.73 mm and 22.53 +/- 4.98 mm; TBUT, 5.29 +/- 2.92 seconds and 13.38 +/- 1.72; Corneal staining, tear meniscus area, 0.026 +/- 0.012 mm(2) and 0.11 +/- 0.025 mm(2); tear meniscus depth, 182.75 +/- 78.79 mu m and 257.48 +/- 90.1 mu m; tear meniscus height, 290.3 +/- 133.63 mu m and 459.78 +/- 180.26 mu m, in patients and controls, respectively). The tear parameters of the duloxetine group were lowest among the drug groups and Schirmer test, and TBUT of the venlafaxine group was statistically significantly different from the duloxetine group (P = 0.028 and P = 0.017, respectively). Ocular Surface Disease Index score of the depression group was significantly higher than the control group (31.12 +/- 21.15 and 17.43 +/- 11.75 in depression and control group, respectively.) Conclusions We found that the usage of selective serotonin reuptake inhibitors and serotonin noradrenaline reuptake inhibitors affects the ocular surface by a mechanism other than the anticholinergic system. Besides serotonin blockage, the noradrenaline blockade of serotonin noradrenaline reuptake inhibitors may increase the dry eye findings on the ocular surface.
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    Evaluation of Iridocorneal Angle, Choroidal Thickness, and Retinal Nerve Fiber Layer Thickness in Children With a History of Retinopathy of Prematurity
    (2020) Ulusoy, Mahmut Oguz; Kivanc, Sertac Argun; Kal, Ali; 31790064
    Purpose: Retinopathy of prematurity (ROP) is proliferative retinopathy affecting premature infants associated with abnormal maturation of the retinal vasculature. We sought to evaluate iridocorneal angle, choroidal thickness, and retinal nerve fiber layer thickness (RNFLT) of the children that have a history of ROP using spectral-domain optical coherence tomography. Patients and Methods: Fifty eyes of 28 children with a history of ROP and 46 eyes of 23 healthy school-aged children were included in this study. RNFLT, choroidal thickness, and iridocorneal angle parameters [trabecular iris angle, angle opening distance (AOD500), and trabecular iris space area (TISA500) 500 mu m from the scleral spur] were evaluated using spectral-domain optical coherence tomography. Student t test was used to compare the mean of the parameters. Correlations between the variables were investigated based on the Pearson or Spearman correlation coefficient. Results: Subfoveal (ROP: 253.98 +/- 42.5; control: 286.2 +/- 71.9; P=0.045), 500 mu m (ROP: 242.04 +/- 41.8; control: 276.7 +/- 45.3; P=0.003), 1000 mu m (ROP: 237 +/- 39.7; control: 270.15 +/- 55.93; P=0.007), and 1500 mu m (ROP: 224.16 +/- 37.5; control: 259.75 +/- 55.2; P=0.003) temporal choroidal thicknesses were significantly thinner in ROP history children. None of the RNFLT parameters and ganglion cell complex thickness were different between groups. Iridocorneal angle parameters were significantly lower in children with ROP history. (trabecular iris angle: ROP=31.35 +/- 3.9 degrees, control=35.4 +/- 4.5 degrees, P<0.001; TISA500: ROP=0.167 +/- 0.05 mm(2), control=0.21 +/- 0.05 mm(2), P=0.003; AOD500: ROP=480.96 +/- 160.4 mu m, control=542.95 +/- 161.2 mu m, P=0.035). Conclusions: ROP is associated with differences in the iridocorneal angle. Possible iridocorneal angle pathology should be a consideration in children with a history of ROP.