Fakülteler / Faculties

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Author: search.filters.author.Oltu, Burcu

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    A Systematic Review of Transfer Learning-Based Approaches for Diabetic Retinopathy Detection
    (2023) Oltu, Burcu; Karaca, Busra Kubra; Erdem, Hamit; Ozgur, Atilla; 0000-0002-9237-8347; 0000-0003-1704-1581; AAD-6546-2019
    Diabetic retinopathy, which is extreme visual blindness due to diabetes, has become an alarming issue worldwide. Early and accurate detection of DR is necessary to prevent the progression and reduce the risk of blindness. Recently, many approaches for DR detection have been proposed in the literature. Among them, deep neural networks (DNNs), especially Convolutional Neural Network (CNN) models, have become the most offered approach. However, designing and training new CNN architectures from scratch is a troublesome and labor-intensive task, particularly for medical images. Moreover, it requires training tremendous amounts of parameters. Therefore, transfer learning approaches as pre-trained models have become more prevalent in the last few years. Accordingly, in this study, 43 publications based on DNN and Transfer Learning approaches for DR detection between 2016 and 2021 are reviewed. The reviewed papers are summarized in 4 figures and 10 tables that present detailed information about 29 pre-trained CNN models, 13 DR data sets, and standard performance metrics.
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    Sleep Apnea Detection Using Blood Pressure Signal
    (2018) Aksahin, Mehmet Feyzi; Oltu, Burcu; Karaca, Busra Kubra
    Sleep apnea is a common respiratory disease. Apnea affects sleep quality, reduces people's life standards, and it can result in death at advanced stage. Therefore the ability to detect the apnea quickly and accurately is important for the treatment of this disease. Apnea is diagnosed by specialists however this is a long and exhausting process. Accordingly, a decision support system that automatically diagnoses apnea has been developed to facilitate this process and make it more objective. The developed decision support system in this study is based on patient's blood pressure signals instead of traditional Polysomnography (PSG) records, which requires various physiological signals measured from the patients. In the examined blood pressure signals, the change that results from each heart beat was determined and heart rate variability (HRV) was calculated based on these changes. At the same time, maximum and minimum amplitude values were found for each change period and amplitude variability vector was created. The features for each epoch were determined using the generated amplitude variability vector and HRV data. Presence of apnea in each epoch is classified with determined features and with the use of "Quadratic SVM" classifier. The Quadratic SVM classifier was trained with 87.5% accuracy and then the system is tested. As a result 75.4% sensitivity and 75% positive predictive values were obtained.
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    Classification of Heart Sound Recordings With Continuous Wavelet Transform Based Algorithm
    (2018) Karaca, Busra Kubra; Oltu, Burcu; Kantar, Tugce; Kilic, Erkin; Aksahin, Mehmet Feyzi; Erdamar, Aykut
    Cardiovascular diseases are the major cause of death in the world. Early diagnosis of heart diseases provide an effective treatment. Heart diseases can be diagnosed using data obtained from heart sounds. Heart sounds are listened by a physician with auscultation method and the disease diagnosis can vary depending on the physician's experience and hearing ability. For this reason, automatic detection of anomalies in heart sounds can give more objective results. In this study, features were obtained by processing phonocardiogram signals taken from Physionet database. The heart sounds are classified as normal and abnormal using these features and the k - nearest neighbor method. As a result, sensitivity, specificity and accuracy were determined as 100%, 96.1% and 98.2%, respectively.
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    Classification of Sleep Apnea by Photoplethysmography Signal
    (2018) Aksahin, Mehmet Feyzi; Karaca, Busra Kubra; Oltu, Burcu
    Sleep apnea is a very common respiratory disorder in the community that includes a range from upper airway obstruction to respiratory abnormalities and the absence of a breathing effort, which can lower people's standard of living and even cause death. Therefore, the sleep apnea needs to be diagnosed in a practical way and with high accuracy. The diagnosis of apnea is made by recording the physiological parameters of the patient with polysomnography (PSG) method and by examination of these parameters by specialist physicians, but it is a tedious and time consuming process. In order to simplify the apnea diagnosis process, phospletismography (PPG) signals are used instead of PSG records. PPG signals are suitable for diagnosis of apnea because they reflect changes in respiration. In the proposed study, a decision support system was developed to automatically diagnose apnea and to make apnea diagnosis easier and more objective using PPG signals. In the decision support system, the peaks of the PPG signal were determined and the heart rate variability (HRV) vector was generated depending on the time difference between these peaks. The mean and standard deviation values of the generated vector are determined as features for each epoch. The presence of the apnea at each epoch is classified using "Subspace K Nearest Neighbor (Subspace KNN)" and specified features. The "Subspace KNN" classifier was trained with 85% accuracy and then system was tested. As a result, sensitivity, accuracy and specificity rates were calculated as 91%, 95% and 90% respectively.
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    A novel electroencephalography based approach for Alzheimer's disease and mild cognitive impairment detection
    (2021) Oltu, Burcu; Aksahin, Mehmet Feyzi; Kibaroglu, Seda; 0000-0002-3964-268X; AAJ-2956-2021
    Background and objective: Alzheimer's disease (AD) is characterized by cognitive, behavioral and intellectual deficits. The term mild cognitive impairment (MCI) is used to describe individuals whose cognitive impairment departing from their expectations for the age that does not interfere with daily activities. To diagnose these disorders, a combination of time-consuming, expensive tests that has difficulties for the target population are evaluated, moreover, the evaluation may yield subjective results. In the presented study, a novel methodology is developed for the automatic detection of AD and MCI using EEG signals. Methods: This study analyzed the EEGs of 35 subjects (16 MCI, 8 AD, 11 healthy control) with the developed algorithm. The algorithm consists of 3 methods for analysis, discrete wavelet transform(DWT), power spectral density (PSD) and coherence. In the first approach, DWT is applied to the signals to obtain major EEG sub-bands, afterward, PSD of each sub-band is calculated using Burg's method. In the second approach, interhemispheric coherence values are calculated. The variance and amplitude summation of each sub-bands' PSD and the amplitude summation of the coherence values corresponding to the major sub-bands are determined as features. Bagged Trees is selected as a classifier among the other tested classification algorithms. Data set is used to train the classifier with 5-fold cross-validation. Results: As a result, accuracy, sensitivity, and specificity of 96.5%, 96.21%, 97.96% are achieved respectively. Conclusion: In this study, we have investigated whether EEG can provide efficient clues about the neuropathology of Alzheimer's Disease and mild cognitive impairment for early and accurate diagnosis. Accordingly, a decision support system that produces reproducible and objective results with high accuracy is developed.
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    Automated Tuberculosis Detection Using Pre-Trained CNN and SVM
    (2021) Oltu, Burcu; Guney, Selda; Dengiz, Berna; Agildere, Muhtesem
    Tuberculosis (TB) is a dreadfully contagious and life-threatening disease if left untreated. Therefore, early and accurate diagnosis is critical for treatment. Today, invasive, expensive, or time-consuming tests are performed for diagnosis. Unfortunately, accurate TB diagnosis is still a major challenge. In the proposed study, a decision support system that can automatically separate normal and TB chest X-ray (CXR) images is presented for objective and accurate diagnosis. In the presented methodology, first various data augmentation methods were applied to the data set, then pre-trained networks (VGG16, MobileNet), were employed as feature extractors from augmented CXR's. Afterward, the extracted features for all images were fed into a support vector machine classifier. In training process, 5-fold cross-validation was applied. As a result of this classification, it was concluded that TB can be diagnosed with an accuracy of 96,6% and an area under the ROC curve (AUC) of 0,99.
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    Heart sound recording and automatic S1-S2 waves detecting system design
    (2020) Aksahin, Mehmet Feyzi; Oltu, Burcu; Karaca, Busra Kubra
    The second leading cause of death in the world is cardiovascular diseases. Diagnosis of vast majority of cardiovascular diseases is made by listening to heart sounds by specialists (auscultation method). However, since the method of auscultation depends on the experience and hearing ability of the specialist, obtained results can be subjective. Therefore, digitization and visualization of heart sounds enables accurate, rapid and economical diagnosis of cardiovascular diseases, especially heart valve diseases. For this purpose, a device prototype that collects the heart sound from human body and also amplifies, filters, displays and records collected data on digital environment was designed in the first part of this study. In order to test the working accuracy of the designed device, clinical applications were carried out with the permission of the ethics committee and as the result of this application 15 heart sound recordings from 5 different disease groups(mitral insufficiency, mitral-aortic insufficiency, mitral-tricuspid insufficiency, mitral-aortic tricuspid insufficiency and healthy heart sound recordings) were collected.and obtained recordings were examined. The most effective parameter for the diagnosis of heart valve diseases is the location of the S1-S2 heart sounds. For this reason, in the second part of the study, a medical decision support system was established to detect the S1-S2 locations to assist physicians in their diagnosis. In this context, heart sounds are first filtered by discrete wavelet transform. Then, the S1-S2 waves in the filtered signal are made evident by the teager energy operator and rule-based algorithm. As a result, S1-S2 locations in normal and pathological data were detected with 98.67% sensitivity, 97.69% specificity and 98.18% accuracy.