Fakülteler / Faculties
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Item Comparison of Glomerular Filtration Rate Measurements with Two Plasma and Single Plasma Sample Methods in Renal Transplant Cases with Stable Renal Graft Functions(2015) Oner, Ali Ozan; Aydin, Funda; Ipekci, Tumay; Sipahi, Murat; Suleymanlar, Gultekin; Gungor, Firat; 0000-0002-2755-0526; 25643901; AAB-2986-2020This study was planned to determine the efficacies of single plasma sample methods (SPSMs) in indicating glomerular filtration rate (GFR) by taking two plasma sample method (TPSM) as reference in the determination of the GFR in cases with clinically stable renal transplantation. Ninety-six renal transplantation cases (33 female, 63 male; age interval 18-67, mean age 37.46 +/- A 11.81 years) progressing stably clinically and as laboratory, with minimum 6 months after transplantation were included in the study. The GFR values of the cases were measured with SPSM and TPSM. It is observed that all SPSMs have a strong correlation with TPSM. Highest correlation was observed between Groth&Aasted SPSM and TPSM GFR (intraclass correlation coefficient: 0.965). In the analyses performed by using the Bland-Altman analysis, GFR values calculated by all SPSMs were concordant to the TPSM which is the gold standard method in 95 % confidence interval (average +/- A 1.96 standard deviation) and were within the clinically acceptable limits. The narrowest concordance interval was obtained between Groth&Aasted Tc-99 m DTPA SPSM and Tc-99 m DTPA TPSM..Besides, we have obtained the minimum bias and precision value by the Groth&Aasted method. As a result; we can see that all the SPSMs give reliable results in measuring GFR in cases with renal transplantation; besides, we suggest Groth&Aasted method as the first option.Item Clinical and Bacteriological Efficacy of Amikacin in The Treatment of Lower Urinary Tract Infection Caused by Extended-Spectrum Beta-Lactamase-Producing Escherichia Coli or Klebsiella Pneumoniae(2014) Ipekci, Tumay; Seyman, Derya; Berk, Hande; Celik, Orcun; https://orcid.org/0000-0002-2755-0526; 25179392; AAB-2986-2020Urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase (ESBL)-producing bacteria have become a growing problem limiting therapeutic options. The aim of this study was to investigate the clinical and microbiological efficacy of amikacin treatment in adult patients with lower UTIs due to ESBL-producing Escherichia coli (Ec) or Klebsiella pneumonia (Kp). We conducted a retrospective study of 36 outpatients aged >18 years with dysuria or problems with frequency or urgency in passing urine; pyuria and a positive urine culture (10(5) cfu/ml) for ESBL producing Ec or Kp which is also resistant to nitrofurantoin, fosfomycin, quinolones and trimethoprim/sulfamethoxazole, between January 2013 and February 2014. Patients received intramuscular amikacin 15 mg/kg/day for 10 days. Clinical success was defined as disappearance of symptoms. Bacteriological success was defined as sterile control urine cultures. 58.3% of patients were female. Age range was 18-89 years. All of the patients had at least one complicating factor. 77.8% of the isolates were E. coli. Clinical success rate was 97.2%. Overall bacteriological success rates were 91.7% on the 3 day of treatment, 97.1% at the end of the treatment and 94.1% on the 7-10 days after treatment. After 28-32 days following the treatment, reinfection was found in 12% whereas relapse was not determined. Nephrotoxicity was developed in one patient. The clinicians should keep in mind that amikacin treatment is an efficient and safe alternative treatment option before the carbapenem treatment especially in patients with lower UTIs caused by ESBL-producing Ec or Kp that are resistant to all oral antibiotics. (C) 2014, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.Item Efficacy of Silodosin in the Treatment of Distal Ureteral Stones 4 to 10 Mm in Diameter(2015) Yuksel, Mustafa; Yilmaz, Serdar; Tokgoz, Husnu; Yalcinkaya, Soner; Bas, Serkan; Ipekci, Tumay; Yildiz, Ali; Ates, Nihat; Savas, Murat; 0000-0002-3068-4699; 0000-0002-2755-0526; 0000-0003-0293-9989; 26770537; AAD-5570-2019; AAB-2986-2020; GWC-8116-2022Purpose: Few studies have investigated the efficacy of silodosin, a recently introduced selective alpha 1-A adrenoceptor antagonist, in medical expulsive therapy (MET) for ureteral calculi. The results of these studies, which all evaluated the efficacy of 8 mg/day, indicate that silodosin is a potential treatment for ureteral calculi. This study investigated the efficacy of 4 mg/day of silodosin for MET of distal ureteral stones 4 to 10 mm in diameter. Material and Method: After 70 patients had been randomized into 2 groups of 35 patients each, both the control and experimental groups (groups 1 and 2, respectively) were advised to take 75 mg/day of diclofenacsodiumas needed for pain relief but only the experimental group to take 4 mg/day of silodosin. After 21 days, the groups were compared regarding the stone expulsion rate and duration, number of renalcolicepisodes, and analgesicdosage. Results: The median expulsion rates were 71.4% and 91.4% in groups 1 and 2, respectively, and the difference between them was significant (P= 0.031). The median expulsion durations were 12.91 +/- 6.14 and 8.03 +/- 4.99 days, respectively, and the difference between them was significant (P< 0.001). No significant differences were found regarding the median number of renal colic episodes or median analgesic dosage. While no patients in group 1 experienced side effects, 5 patients (14%) in group 2 experienced retrograde ejaculation. Conclusion: These results indicate that 4 mg/day of silodos in facilitates the expulsion of distal ureteral stones 4 to 10 mm in diameter but does not significantly reduce the number of renal colic episodes or analgesic dosage.Item An Extremely Rare Cause of Hematuria: Adamantinoma like Neuroectodermal Tumor of Bladder(2016) Yilmaz, Serdar; Ipekci, Tumay; Akin, Yigit; https://orcid.org/0000-0002-2755-0526; AAB-2986-2020Primary primitive neuroectodermal tumour (PNET) is a rare entity and have severe malign potential. However, PNET is derived from central nervous system, it can rarely occur in another soft tissue. Herein, we present an extremely rare cause of hematuria in an 83-year-old man, who was diagnosed as adamantinoma like PNET, in bladder. After transurethral surgical treatment, there was no recurrence, in short-term clinical follow-up. According to our best knowledge, he was the oldest patient who had PNET in bladder, in published literature.Item Changes in Expressions of ADAM9, 10, and 17 As Well as Alpha-Secretase Activity in Renal Cell Carcinoma(2017) Erin, Nuray; Ipekci, Tumay; Akkaya, Bahar; Ozbudak, Irem Hicran; Baykara, Mehmet; https://orcid.org/0000-0002-2755-0526; https://orcid.org/0000-0001-6687-1587; 27692848; AAB-2986-2020; C-4815-2016Background: ADAM9, 10, and 17 are a class of disintegrins and metallproteinases with oc-secretase activity. There are conflicting results regarding the role(s) of ADAM9, 10, and 17 in carcinogenesis, and only a few studies have examined their levels and cellular localization in renal cell carcinoma (RCC). Studies examining changes in oc-secretase activity in RCC compared to enzymatic activity of the uninvolved kidney are lacking. Method: A cross-sectional study was conducted in 56 patients undergoing radical nephrectomy after the diagnosis of RCC. alpha-Secretase activity was determined using flourogenic substrate in freshly frozen tumor tissues as well as similarly treated tissues from the neighboring kidney. Immunohistochemical analyses of ADAM9, 10, and 17 were also performed. Results: alpha-Secretase activity decreased markedly in all types of RCC as compared to neighboring uninvolved kidney tissue having 5 to 10 times higher levels of oc-secretase activity. Although type-dependent variations were observed, tumoral expressions of ADAMs, except for ADAM17, were lower in the tumors compared to that of neighboring tissues, but the changes in oc-secretase activity were greater. In RCC tissue, ADAM9 expressions were localized in nuclear and cytoplasmic compartments, whereas ADAM10 and 17 were present predominately in the cytoplasm potentially explaining the markedly decreased enzyme activity. Membranous localization of ADAMs was noted in uninvolved kidney tissue. Conclusions: The loss of alpha-secretase activity observed here in conjunction with previous findings argue against tumorigenic effects of ADAM9, 10, and 17 supporting that increased nuclear and cytoplasmic expression may be an attempt to compensate for loss of function. (C) 2017 Elsevier Inc. All rights reserved.Item The impact of Technetium-99m dimercapto-succinic acid scintigraphy on DNA damage and oxidative stress in children(2021) Varol, Selcuk; Oktem, Faruk; Kocyigit, Abdurrahim; Demir, Aysegul Dogan; Karatas, Ersin; Aydin, Mehmet; Goknar, Nilufer; Ipekci, Tumay; 34487588Background Technetium-99m-dimercapto succinic acid (Tc-99m DMSA) scintigraphy is a commonly used imaging modality in children with urological abnormalities. The radiopharmaceuticals, which have the effects of ionising radiation, are used in this method. This study aimed to investigate the impact of the Tc-99m DMSA scan on renal oxidative stress and mononuclear leukocyte (MNL) DNA damage. Methods Children, who were followed up by paediatric nephrology at Bezmialem Vakif University and underwent Tc-99m DMSA scintigraphy between April 2015 and January 2016 with the indication of detection of renal scars, were included in this study. The exclusion criteria were nephrolithiasis, history of premature birth and recent urinary tract infection 3 months prior to scintigraphy or antibiotic use in the last 1 month. 3 mL heparinised blood samples were obtained just before, immediately after and 1 week after the scintigraphy. MNL DNA damage, total antioxidant status (TAS) and total oxidant status (TOS) were measured in the blood samples. The oxidative stress index (OSI) was calculated. Spot urine samples were obtained from each patient before and within 3 days after performing the scintigraphy. TAS/Creatinine (TAS/Cr), TOS/Creatinine (TOS/Cr) and N-acetyl-glucosaminidase/creatinine (NAG/Cr) levels were measured in the urine samples. Results Twenty-seven children were evaluated. The values between TAS, TOS and OSI levels in serum samples at baseline, immediately after and 1 week after the scintigraphy (P = .105, P = .913, and P = .721, respectively) showed no statistically significant difference. The levels of TAS/Cr, TOS/Cr, NAG/Cr ratios and OSI, which were evaluated from urine samples before and within 3 days after the scintigraphy scan were also similar (P = .391, P = .543, P = .819 and P = .179, respectively). The levels of DNA damage only increased following scintigraphy scan and decreased a week later (P < .05). Conclusions The effect of Tc-99m DMSA scintigraphy is insufficient to create oxidative damage, but it can cause DNA damage via the direct impact of ionising radiation which can be repaired again in a short time.Item Cardiac Failure Associated with Medical Therapy of Benign Prostatic Hyperplasia: A Population Based Study. Letter(2021) Coner, Ali; Ipekci, Tumay; 33835864Item Predictors of Pain During Cystoscopy(2015) Ipekci, Tumay; Akin, Yiğit; Hoscan, Mustafa BurakItem Sexual Dysfunction in Women with Chronic Renal Failure(2015) Ipekci, Tumay; Hoscan, Mustafa BurakItem Goserelin Treatment and Blood Loss Associated with Transurethral Resection of the Prostate(2015) Ipekci, Tumay; Unal, Betul; Hoscan, Mustafa Burak
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