Fakülteler / Faculties
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Item Turkish Society of Pediatric Nephrology - February 6th Earthquakes Disaster Management(2023) Bakkaloglu, Sevcan; Yavascan, Onder; Yilmaz, Alev; Gulleroglu, Kaan; Kasap Demir, Belde; Ertan, Pelin; Poyrazoglu, Hakan; 0000-0003-1434-3824; F-3294-2013Item Success of Eculizumab in the Treatment of Atypical Hemolytic Uremic Syndrome(2015) Baskin, Esra; Gulleroglu, Kaan; Kantar, Asli; Bayrakci, Umut; Ozkaya, Ozan; 0000-0003-1434-3824; 0000-0003-1434-3824; 0000-0003-4361-8508; 25384530; F-3294-2013; AAJ-8833-2021; B-5785-2018Disorders of complement regulation are the most important etiology of atypical hemolytic uremic syndrome (aHUS). Recent studies demonstrate that eculizumab is beneficial in long-term aHUS treatment. We present a series of children with aHUS resistant to/dependent on plasma exchange (PE) who were treated with eculizumab. This was a retrospective study in which data were retrieved from the medical files of children who had received PE as treatment for aHUS. The data retrieved included age, sex, presenting symptoms, presence of diarrhea/vomiting, hospitalization duration, laboratory data on admission and follow-up, need for transfusion or dialysis, response to PE, response to eculizumab and outcome. Of the 15 children diagnosed with aHUS in 2011 and 2012 in our departments, ten were resistant to, or dependent on, plasma therapy and treated with eculizumab; these children were enrolled in the study. Three patients had relapses, and seven had a new diagnosis. Nine children had oliguria or anuria, and eight required dialysis. Hypertension was observed in six patients. Neurologic involvement developed in six patients, with the symptoms including seizures, loss of balance, vision loss and severe confusion. Five and five patients were resistant to and dependent on plasma therapy, respectively. Following the start of eculizumab treatment, all patients achieved full recovery of renal function and hematologic parameters. In our ten pediatric patients with aHUS who did not respond to PE, eculizumab was a lifesaving therapy and improved their quality of life. Early eculizumab use was a rescue therapy for renal function. Our results show that eculizumab is an effective treatment for aHUS. However, more studies are needed on the long-term efficacy and safety of eculizumab in children with aHUS and to determine the optimal duration of treatment.Item Neuroblastoma Accompanied by Hyperaldosteronism(2014) Gulleroglu, Kaan; Bayrakci, Umut; Kinik, Sibel Tulgar; Uslu, Nihal; Atilgan, Alev O. K.; Sarialioglu, Faik; Baskin, Esra; https://orcid.org/0000-0003-1434-3824; https://orcid.org/0000-0002-6733-8669; https://orcid.org/0000-0001-8595-8880; https://orcid.org/0000-0002-8257-810X; https://orcid.org/0000-0003-4361-8508; 25340174; AAJ-8833-2021; ABC-5258-2020; AAK-3333-2021; AAL-7766-2021; B-5785-2018Background: Tumors known derived from kidneys which take place in secondary hyperaldosteronism etiology are juxtaglomerular cell tumor and Wilms' tumor. Neuroblastoma presenting with hyperaldosteronism is rare. Case: A 15-month-old girl who had been having diarrhea and fever for 2 weeks presented with a 3 day history of bilious vomiting, metabolic acidosis and severe hypokalemia. She was referred to our hospital with the pre-diagnosis of unknown manifest hypertension etiology, diarrhea, and paralytic ileus after having therapy-resistant hypokalemia and severe resistant acidosis. On her examination after being admitted to our clinic, she was weak, unwell and lethargic with a blood pressure of 140/93 mmHg. Due to the hypertension and severe hypokalemia, the patient was considered to be hyperaldosteronism. Serum aldosterone level, plasma renin activity and cortisol level were elevated. Radiologic findings were compatible with neuroblastoma. The patient underwent an abdominal surgery and the mass excision. The histopathological examination was proved neuroblastoma. Conclusion: Hyperaldosteronism can be presented by unexpected atypical forms as in our patient.Item The Effect of Anti-hla Antibodies on Renal Graft Functions(2014) Baskin, Esra; Gulleroglu, Kaan; Kantar, Asli; Kirnap, Mahir; Karakayali, Feza; Haberal, Aysegul; Moray, Gokhan; Haberal, Mehmet; https://orcid.org/0000-0003-4361-8508; https://orcid.org/0000-0003-1434-3824; https://orcid.org/0000-0002-1874-947X; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-3462-7632; B-5785-2018; F-3294-2013; AAH-9198-2019; AAB-3888-2021; AAE-1041-2021; AAJ-8097-2021Item Effects of Hyperuricemia on Renal Function in Pediatric Renal Transplant Recipients(2014) Baskın, Esra; Fidan, Cihan; Kantar, Asli; Gulleroglu, Kaan; https://orcid.org/0000-0003-4361-8508; https://orcid.org/0000-0002-9093-1524; https://orcid.org/0000-0003-1434-3824; B-5785-2018; F-5830-2019; AAJ-8833-2021Item Association Between Heat Shock Protein-72 Gene Polymorphism and Chronic Renal Failure in Children(2014) Gulleroglu, Kaan; Baskin, Esra; Kantar, Asli; Sahin, Feride; https://orcid.org/0000-0003-1434-3824; https://orcid.org/0000-0003-4361-8508; https://orcid.org/0000-0001-7308-9673; F-3294-2013; B-5785-2018; AAC-7232-2020Item Fractalkine Receptor Gene Polymorphisms and Chronic Renal Disease(2014) Gulleroglu, Kaan; Baskin, Esra; Kantar, Asli; Sahin, Feride; https://orcid.org/0000-0003-1434-3824; https://orcid.org/0000-0003-4361-8508; AAJ-8833-2021; B-5785-2018Item Eculizumab in the Treatment of Dense Deposit Disease(2015) Gulleroglu, Kaan; Avci, Begum; Kantar, Asli; Ozdemir, Handan; Baskin, Esra; 0000-0002-5375-379X; 0000-0003-1434-3824; 0000-0002-7528-3557; 0000-0003-1434-3824; 0000-0003-4361-8508; GYU-5220-2022; AAJ-8833-2021; X-8540-2019; F-3294-2013; B-5785-2018Item Prophylactic Eculizumab Therapy for Atypical Hemolytic Uremic Syndrome in A Pediatric Renal Transplant Patient(2015) Avci, Begum; Baskin, Esra; Gulleroglu, Kaan; Kantar, Asli; Moray, Gokhan; Haberal, Mehmet; 0000-0002-3462-7632; 0000-0003-4361-8508; 0000-0003-1434-3824; 0000-0003-2498-7287; 0000-0003-1434-3824; 0000-0002-5375-379X; AAJ-8097-2021; B-5785-2018; F-3294-2013; AAE-1041-2021; AAJ-8833-2021; GYU-5220-2022Item Effects of Late Acute Rejection on Graft Survival and Outcome in Pediatric Renal Transplant Recipients(2015) Baskin, Esra; Kantar, Asli; Gulleroglu, Kaan; Ozmen, Esra; Ozdemir, Handan; Kirnap, Mahir; Moray, Gokhan; Haberal, Mehmet; 0000-0002-3462-7632; 0000-0002-7528-3557; 0000-0003-2498-7287; 0000-0003-1434-3824; 0000-0003-4361-8508; /0000-0003-1434-3824; AAJ-8097-2021; X-8540-2019; AAE-1041-2021; F-3294-2013; B-5785-2018; AAH-9198-2019; AAJ-8833-2021