Fakülteler / Faculties

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Author: search.filters.author.Bal, Zeynep

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    Hypoalbuminemia, Poor Calcium-Phosphorus Control and High Transporter Peritoneal Characteristics - Three Important 10-Year Survival Predictors for Peritoneal Dialysis Patients
    (2014) Tutal, Emre; Bal, Zeynep; Sezer, Siren; Uyar, Mehtap Erkmen; 0000-0002-7326-8388; IAO-2608-2023; AAZ-5795-2021; JYQ-2550-2024
    OBJECTIVE: Peritoneal transport characteristic is a potential survival predictor. In this study we evaluated the effect of transport characteristics on 10 year patient survival and compared its' impact with other possible survival predictors. MATERIAL and METHODS: We included 75 CAPD patients who were followed in our center for at least 10 years after initiation of PD. Based on the standard peritoneal equilibration test, PD patients were divided into two transporter groups: Low / Low average (n: 27) and High / High Average (n: 48). Clinical and demographic data were collected from patient charts and impact of transporter characteristics and some other well-known survival predictors were studied. RESULTS: 10 year PD survival rates were significantly lower in H/HA group (p: 0.001). Atherosclerosis-related mortality rate was significantly higher in H/HA group (45.9% vs. 7.6%, p: 0.043). Hypoalbuminemia, increased CaxP, chronic inflammation, H/HA transport status were independent predictors of PD and patient survival. Further analysis revealed that hypoalbuminemia (p: 0.0001) and increased CaxP levels (p: 0.0001) were the main predictors. CONCLUSION: This study suggests that peritoneal transport status is an important survival predictor. However keeping the calcium and phosphorus levels in recommended ranges, and improving nutritional status still have more importance for lowering mortality rates of PD patients.
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    Differential Influence of Vitamin D Analogs on Left Ventricular Mass Index in Maintenance Hemodialysis Patients
    (2014) Sezer, Siren; Tutal, Emre; Bal, Zeynep; Uyar, Mehtap Erkmen; Bal, Ugur; Cakir, Ulkem; Acar, Nurhan Ozdemir; Haberal, Mehmet; https://orcid.org/0000-0002-7326-8388; https://orcid.org/0000-0002-9446-2518; https://orcid.org/0000-0002-3462-7632; 24619898; JYQ-2550-2024; AAZ-5795-2021; AAK-4322-2021; AAJ-8097-2021
    Purpose: Secondary hyperparathyroidism (SHPT) is a common feature in maintenance hemodialysis (MHD) patients. Inadequate treatment of SHPT has been associated with cardiovascular complications, and vitamin D therapy might influence the development of cardiovascular diseases. In the present study, we aimed to evaluate the effects of intravenous paricalcitol and calcitriol treatments on left ventricular mass index changes in MHD patients. Methods: We conducted an observational study with a 12-month follow-up duration to compare the outcomes of intravenous paricalcitol and calcitriol treatments in MHD patients. Eighty patients with moderate to severe SHPT were enrolled in the study. All the patients had normalized total serum Ca concentration <10.5 mg/dL, serum calcium-phosphorus product (Ca x P) <75, and parathyroid hormone level (PTH) level >= 300 pg/mL at the begining of the follow-up period. Results: The patients were divided into a paricalcitol group (n = 40) and a calcitriol group (n = 40). The demographic, clinical, and biochemical characteristics of the patients were similar at baseline. We observed significantly superior control of SHPT; lesser frequency of hypercalcemia and hyperphosphatemia, and Ca x P level elevations; and interruption of vitamin D treatment in the paricalcitol group. Moreover, we found no significant change in left ventricular mass index in the paricalcitol group, but found a significantly increased left ventricular mass index in the calcitriol group during the follow-up period (from 136.6 +/- 35.2 g/m(2) to 132.9 +/- 40.4 g/m(2) vs. from 137.2 +/- 30.1 g/m(2) to 149.4 +/- 31.0 g/m(2); p<0.044). Conclusion: We observed that, compared with calcitriol therapy, paricalcitol therapy reduced the PTH concentrations more effectively without causing hypercalcemia and hyperphosphatemia and might have a substantial beneficial effect on the development of left ventricular hypertrophy.
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    Hyperproteinuria As A Cardiovasculary Risk Factor in Renal Transplant Recipients
    (2014) Guliyev, Orhan; Uyar, Mehtap Erkmen; Sezer, Siren; Bal, Zeynep; Colak, Turan; Demirci, Bahar Gurlek; Acar, Nurhan Ozdemir; Haberal, Mehmet; https://orcid.org/0000-0002-7326-8388; https://orcid.org/0000-0002-8372-7840; https://orcid.org/0000-0002-3462-7632; JYQ-2550-2024; AAZ-5795-2021; AAJ-8554-2021; AAJ-8097-2021
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    Oxidative Stress in Maintenance Hemodialysis Patients
    (2014) Uyar, Mehtap Erkmen; Bal, Zeynep; Bayraktar, Nilufer; Demirci, Bahar Gurlek; Sayin, Burak; Sezer, Siren; https://orcid.org/0000-0002-7886-3688; https://orcid.org/0000-0001-8287-6572; https://orcid.org/0000-0002-7326-8388; IAO-2608-2023; AAZ-5795-2021; Y-8758-2018; J-3707-2015; JYQ-2550-2024
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    Relationship Between Proteinuria and Pulsewave Velocity in Patients with Stage 1-4 Chronic Kidney Disease
    (2014) Uyar, Mehtap Erkmen; Tutal, Emre; Bal, Zeynep; Guliyev, Orhan; Sezer, Siren; https://orcid.org/0000-0002-7326-8388; IAO-2608-2023; AAZ-5795-2021; JYQ-2550-2024
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    Low 25-Hydroxy Vitamin D, High Fibroblast Growth Factor 23 and Arterial Stiffness in Hemodialysis Patients with Chronic Kidney Disease: "The Chicken or Egg Phenomenon"
    (2014) Bal, Zeynep; Uyar, Mehtap Erkmen; Gokustun, Dilek; Demirci, Bahar Gurlek; Tutal, Emre; Sezer, Siren; https://orcid.org/0000-0002-7326-8388; AAZ-5795-2021; JYQ-2550-2024
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    Sevelamer Decreases Serum Uric Acid Levels and Improves Arterial Stiffness in Hemodialysis Patients
    (2014) Sezer, Siren; Demirci, Bahar Gurlek; Tutal, Emre; Bal, Zeynep; Uyar, Mehtap Erkmen; Acar, Fatma Nurhan Ozdemir; https://orcid.org/0000-0002-7326-8388; https://orcid.org/0000-0002-5682-0943; JYQ-2550-2024; AAZ-5795-2021; AAK-1697-2021
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    Hematological Parameters Can Predict the Extent of Coronary Artery Disease in Patients with End-Stage Renal Disease
    (2015) Bal, Zeynep; Bal, Ugur; Okyay, Kaan; Yilmaz, Mustafa; Balcioglu, Serhat; Turgay, Ozge; Hasirci, Senem; Aydinalp, Alp; Yildirir, Aylin; Sezer, Siren; Muderrisoglu, Haldun; 0000-0002-8342-679X; 0000-0001-6134-8826; 0000-0002-6731-4958; 0000-0002-9635-6313; 0000-0002-3761-8782; 0000-0002-9446-2518; 0000-0001-8750-5287; 0000-0002-2557-9579; 26246038; AAK-7805-2021; AAK-7355-2020; GPX-1387-2022; AAG-8233-2020; AAD-5841-2021; AAK-4322-2021; AAZ-5795-2021; A-4947-2018; S-6973-2016
    Aside from traditional factors (e.g., diabetes, age, and hypertension), some hematological parameters, such as neutrophil-to-lymphocyte ratio (NLR), red blood cell distribution width (RDW), and mean platelet volume (MPV), have increasingly been reported as measures of systemic inflammation and atherosclerosis in patients with end-stage renal disease (ESRD). This study aimed to determine whether there is an association between these hematological parameters and the extent of coronary artery disease (CAD) in patients with ESRD. A total of 149 consecutive ESRD patients (66 % males) without established CAD were studied. NLR, RDW, and MPV values in all patients were calculated from the complete blood count before coronary angiography. Angiographic views were assessed by an experienced interventional cardiologist, and the extent of CAD was evaluated by the Gensini score. The patients were divided into quartiles of the Gensini score. Age, time on dialysis, calcium-phosphorus product, C-reactive protein levels, NLR, and MPV were significantly different among the groups (all p < 0.05). The Gensini score was correlated with age, time on dialysis (both p < 0.001), NLR (p = 0.004), and C-reactive protein levels (p = 0.034) and inversely correlated with left ventricular ejection fraction (p = 0.023). Multivariate regression analysis showed that age (p = 0.001), time on dialysis (p < 0.001), NLR (p = 0.001), and MPV (p = 0.005) were independent predictors of the extent of CAD. Aside from the well-known traditional factors, NLR and MPV are independent predictors of the extent of CAD in patients with ESRD.
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    Sevelamer Decreases Serum Urıc Acıd Levels and Improves Arterıal Stıffness in Hemodıalysıs Patıents
    (2015) Sezer, Siren; Demirci, Bahar Gurlek; Tutal, Emre; Bal, Zeynep; Uyar, Mehtap Erkmen; Acar, Fatma NurhanOzdemir; 0000-0002-5682-0943; IAO-2608-2023; AAZ-5795-2021; AAK-1697-2021
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    Sevelamer Hydrochloride Improves Oxidative Stress in Maintenance Hemodialysis Patients
    (2015) Demirci, Bahar Gurlek; Sayin, Cihat Burak; Tutal, Emre; Bal, Zeynep; Acar, Fatma NurhanOzdemir; Sezer, Siren; 0000-0001-8287-6572; 0000-0002-5682-0943; J-3707-2015; AAK-1697-2021; AAZ-5795-2021