Fakülteler / Faculties

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    A 'Flawless' Constitutional Engineering Project In Turkey: Regime Transformation Through Constitutional Amendments Of 2007, 2010, And 2017
    (Başkent Üniversitesi Hukuk Fakültesi, 2024-04-17) Genckaya, Omer Faruk; Dunbay, Seda
    A functional legislature is very vital for democratisation. During the time of democratic consolidation, parliament changes from its primary roles of oversight, representation and legislation into 'important public arenas of partisan dispute, of encounters with social topics, of negotiations and of important decision-making'. Populist leaders in parliamentary systems like Turkey recently either led to sui generis presidential systems or transformed them into illiberal democracies by expanding the executive branch's power to amend the constitution, which contradicts the favourable conditions of the third wave of democratisation at the turn of the twenty-first century. By streamlining legislative processes, the Turkish Constitution of 1982 envisaged an empowered executive that would subordinate the parliament. The three constitutional modifications passed after 2007 resulted in de-democratisation, de-parliamentarisation and eventually, a regime change from democratic consolidation to autocracy. The parliamentary debates on these constitutional amendments, which included popular presidential election, judicial reform and the so-called 'Turkish style' presidential governance system, failed to reach a consensus and were marked by an adversarial rather than deliberative approach. Have constitutional reforms made in the name of re-democratisation resulted in de-democratisation, with the legislature entirely crippled, the judiciary reliant and the executive exercising sole authority? This study aims to analyse the impact of three consequential constitutional amendments on democratic backsliding in Turkey, with special reference to the decline of parliament. Parliamentary minutes on the relevant constitutional amendments, procedural changes disabling the parliament from performing its legislative and oversight functions and the actual outcomes of these amendments in terms of executive-legislative relations will be discussed. In conclusion, potentials for strengthening parliament, checks and balances, and re-democratisation will be presented.
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    Biochemical And Molecular Analyses Of Insecticide Resistance In Greenhouse Populations Of Bemisia Tabaci (Hemiptera: Aleyrodidae) In Türkiye
    (Başkent Üniversitesi Fen Edebiyat Fakültesi, 2024-04-04) Erdogan, Cem; Toprak, Umut; Gurkan, M. Oktay
    The sweet potato/cotton whitefly Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) is one of the most destructive vegetable pests in greenhouses in Turkiye. While the preferred method of control primarily relies on insecticides such as neonicotinoids, organophosphates and pyrethroids, their intensive use has caused whiteflies to rapidly become resistant. Samples were collected from 13 Turkish B. tabaci greenhouse populations. Bioassays from the Marmara Region identified as high as a 53-fold increase in resistance to chlorpyrifos-ethyl, a 303-fold increase to imidacloprid and a 282-fold increase to acetamiprid. Bioassays in the Central Anatolia Region reported a 76-fold increase in resistance to deltamethrin and-15-fold increase to thiamethoxam. Most of the populations showed cross-resistance for neonicotinoids. All collected B. tabaci populations were determined to be MEAM 1 (also referred to as biotype B) for diagnostic band E0.14. The E0.14 esterase variant that helps to diagnose biotype B insects was found in all individuals from field populations. Almost all populations showed higher non-specific esterase, glutathione-S-transferase (GST) and monooxygenase activity when compared to susceptible SUD-S population. AChE insensitivity assays for individual B. tabaci suggest a target-site modification as a mechanism of resistance to chlorpyrifos-ethyl. This is the first report of AChE variants identified based on their sensitivities to chlorpyrifos ethyl-oxon and pirimicarb in Turkish B. tabaci populations. Fixed ace mutations in the target-site of organophosphates and pyrethroids were identified in six populations. Resistance to organophosphates and neonicotinoids were at least partially related to both ace mutations and insensitive AChE and monooxygenase activities, respectively. The results will help develop effective resistance management programs of B. tabaci in Turkiye.
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    Cardiovascular Multimodality Imaging In Women: A Scientific Statement Of The European Association Of Cardiovascular Imaging Of The European Society Of Cardiology
    (Başkent Üniversitesi Sağlık Bilimleri Fakültesi, 2024-03-27) Almeida, Ana G.; Grapsa, Julia; Gimelli, Alessia; Bucciarelli-Ducci, Chiara; Gerber, Bernhard; Ajmone-Marsan, Nina; Bernard, Anne; Donal, Erwan; Dweck, Marc R.; Haugaa, Kristina H.; Hristova, Krassimira; Maceira, Alicia; Mandoli, Giulia Elena; Mulvagh, Sharon; Morrone, Doralisa; Plonska-Gosciniak, Edyta; Sade, Leyla Elif; Shivalkar, Bharati; Schulz-Menger, Jeanette; Shaw, Leslee; Sitges, Marta; von Kemp, Berlinde; Pinto, Fausto J.; Edvardsen, Thor; Petersen, Steffen E.; Cosyns, Bernard
    Cardiovascular diseases (CVD) represent an important cause of mortality and morbidity in women. It is now recognized that there are sex differences regarding the prevalence and the clinical significance of the traditional cardiovascular (CV) risk factors as well as the pathology underlying a range of CVDs. Unfortunately, women have been under-represented in most CVD imaging studies and trials regarding diagnosis, prognosis, and therapeutics. There is therefore a clear need for further investigation of how CVD affects women along their life span. Multimodality CV imaging plays a key role in the diagnosis of CVD in women as well as in prognosis, decision-making, and monitoring of therapeutics and interventions. However, multimodality imaging in women requires specific consideration given the differences in CVD between the sexes. These differences relate to physiological changes that only women experience (e.g. pregnancy and menopause) as well as variation in the underlying pathophysiology of CVD and also differences in the prevalence of certain conditions such as connective tissue disorders, Takotsubo, and spontaneous coronary artery dissection, which are all more common in women. This scientific statement on CV multimodality in women, an initiative of the European Association of Cardiovascular Imaging of the European Society of Cardiology, reviews the role of multimodality CV imaging in the diagnosis, management, and risk stratification of CVD, as well as highlights important gaps in our knowledge that require further investigation.
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    Categorization Of Alzheimer's Disease Stages Using Deep Learning Approaches With Mcnemar's Test
    (Başkent Üniversitesi Mühendislik Fakültesi, 2024-03-13) Sener, Begum; Acici, Koray; Sumer, Emre
    Early diagnosis is crucial in Alzheimer's disease both clinically and for preventing the rapid progression of the disease. Early diagnosis with awareness studies of the disease is of great importance in terms of controlling the disease at an early stage. Additionally, early detection can reduce treatment costs associated with the disease. A study has been carried out on this subject to have the great importance of detecting Alzheimer's disease at a mild stage and being able to grade the disease correctly. This study's dataset consisting of MRI images from the Alzheimer's Disease Neuroimaging Initiative (ADNI) was split into training and testing sets, and deep learning -based approaches were used to obtain results. The dataset consists of three classes: Alzheimer's disease (AD), Cognitive Normal (CN), and Mild Cognitive Impairment (MCI). The achieved results showed an accuracy of 98.94% for CN vs AD in the one vs one (1 vs 1) classification with the EfficientNetB0 model and 99.58% for AD vs CNMCI in the one vs All (1 vs All) classification with AlexNet model. In addition, in the study, an accuracy of 98.42% was obtained with the EfficientNet121 model in MCI vs CN classification. These results indicate the significant potential for mild stage Alzheimer's disease detection of Alzheimer's disease. Early detection of the disease in the mild stage is a critical factor in preventing the progression of Alzheimer's disease. In addition, a variant of the non -parametric statistical McNemar's Test was applied to determine the statistical significance of the results obtained in the study. Statistical significance of 1 vs 1 and 1 vs all classifications were obtained for EfficientNetB0, DenseNet, and AlexNet models.
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    Ceftobiprole Mono-Therapy Versus Combination Or Non-Combination Regimen Of Standard Antibiotics For The Treatment Of Complicated Infections: A Systematic Review And Meta-Analysis
    (Başkent Üniversitesi Eczacılık Fakültesi, 2024-06-10) Jame, Wissal; Basgut, Bilgen; Abdi, Abdikarim
    Objective: Various bacteria produce complicated infections that are difficult to treat worldwide. Ceftobiprole is effective against resistant Gram-positive and Gram-negative bacteria. Methods: This review assessed effectiveness and safety of ceftobiprole monotherapy for severe infections. A systematic review and meta-analysis of randomized controlled trials comparing clinical cure, microbiological cure, and safety of ceftobiprole alone to a combination or non-combination antibiotic regimen was conducted. Until December 20, 2022, we searched a major databases. Results: This study includes 4168 patients from six trials. Ceftobiprole and comparator-received patients had similar clinical responses for all patient population. Also, the eradication rate of all organisms and specific pathogenic bacteria in microbiologically examined patients was comparable between the groups. Ceftobiprole induced more gastrointestinal side events than comparable drugs, mostly nausea [OR 1.91 (1.26-2.90), p = < 0.01]. While skin-related adverse events were significantly associated with comparator antibiotics [6 trials, 4062 patients; OR 0.77 (0.60-0.99), p=0.03]. Conclusion: Ceftobiprole monotherapy is effective and safe for severe infections caused by Gram-positive or Gram-negative bacteria.
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    Cerliponase Alfa Decreases Aβ Load And Alters Autophagy- Related Pathways In Mouse Hippocampal Neurons Exposed To Faβ1-42
    (LIFE SCIENCES, 2024-11-15) Kose, Selma; Cinar, Elif; Akyel, Hilal; Cakir-Aktas, Canan; Tel, Banu Cahide; Karatas, Hulya; Kelicen-Ugur, Pelin
    Extracellular aggregation of amyloid-beta (A beta) in the brain plays a central role in the onset and progression of Alzheimer's disease (AD). Moreover, intraneuronal accumulation of A beta via oligomer internalization might play an important role in the progression of AD. Deficient autophagy, which is a lysosomal degradation process, occurs during the early stages of AD. Tripeptidyl peptidase-1 (TPP1) functions as a lysosomal enzyme, and TPP1 gene mutations are associated with type 2 late infantile neuronal ceroid lipofuscinosis (LINCL). Nevertheless, there is little information about the role of TPP1 in the pathogenesis of AD; therefore, the present study aimed to measure the decrease in intraneuronal A beta accumulation by a recombinant analog of the TPP1 enzyme, cerliponase alfa (CER) (Brineura (R)), and to determine whether autophagy pathways play a role in this decrease. In this study, endogenous A beta accumulation was induced by fA beta(1-42) (a toxic fragment of full-length A beta) exposure, and mouse hippocampal neuronal cells (HT-22) were treated with CER (human recombinant rhTPP1 1 mg mL-1). Soluble A beta, TPP1, and the proteins involved in autophagy, including mammalian target of rapamycin (p-mTOR/ mTOR), p62/sequestosome-1 (p62/SQSTM1), and microtubule-associated protein 1 A/1B-light chain 3 (LC3), were evaluated using western blotting. The sirtuin-1, beclin-1, and Atg5 genes were also studied using RT-PCR. A beta and TPP1 localizations were observed via immunocytochemistry. CER reduced the A beta load in HT-22 cells by inducing TPP1 expression and converting pro-TPP1 into the mature form. Furthermore, exposure to CER and fA beta(1-42) induced the autophagy-regulatory/related pathways in HT-22 cells and exposure to CER alone increased sirtuin-1 activity. Based on the present findings, we suggest that augmentation of TPP1 with enzyme replacement therapy may be a potential therapeutic option for the treatment of AD.
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    Challenges Of Masked Communication In Healthcare And Facilitating Strategies
    (JOURNAL OF PSYCHIATRIC NURSING, 2024-07-22) Demirel, Yuksel
    Wearing a face mask is one of the main means of preventing the transmission of certain respiratory diseases. This measure, combined with social distancing and hand washing, helps to slow the spread and reduce transmission of the virus, especially among people who are expressed as asymptomatic carriers, while causing communication difficulties between patients and healthcare professionals. If strategies to cope with these difficulties are not developed, serious errors may occur in the field of health services. Because the field of health services is one of the service areas where it is vital to maintain communication without interruption. For this reason, the effective performance of the procedures requires that the health personnel understand the messages correctly and appropriately both in their communication with each other and with the patient and that the patients can adequately express their feelings and thoughts to the healthcare professionals. The aim of this study is to reveal the difficulties and facilitating strategies of masked communication in health services during the COVID-19 process. The method of "document scanning-a literature review" was used as a way of data collection in the research. In this direction, the literature dealing with the importance of the face in expressing emotions in face-to-face communication and the difficulties caused by face masks in communication during the COVID-19 epidemic was scanned using keywords and various combinations of these words.
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    Characterizing The Unseen: Clinical And Radiographic Perspectives On Unilateral Condylar Hyperplasia
    (JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY, 2024-12) Ergezen, Ezgi; Salyut, Ardakgul; Akdeniz, Sidika Sinem; Cubuk, Secil
    Objectives: Unilateral condylar hyperplasia (UCH), marked by progressive condylar growth, occurs between ages 11-30 with unclear etiology. This retrospective study aims to clarify the clinical, radiographic, and demographic features of UCH to improve its diagnosis and treatment. Material and methods: Data for all patients included in this study were retrieved from the archive. Inclusion criteria were the diagnosis of UCH supported by a positive bone scan above 10% of condylar uptake in SPECT/ CT, the patient's history of progressive facial asymmetry, symptoms confirmed by the orthodontist during follow-up, and clinical and radiological evaluation. Demographic characteristics, along with volumetric and linear measurements, were statistically evaluated. Results: Forty-one patients were included in this study with 70.73% female predominance. Patients were classified as transverse and vertical type condylar hyperplasia (CH) according to their prominent asymmetry characteristics. Eighteen patients were classified as vertical type CH and 23 patients were classified as transverse type CH. Twenty had left-side condylar overgrowth, and 21 had right-side overgrowth. Condylar volume difference was significantly higher in vertical type CH patients compared to transverse type CH (p = 0.004). No correlation was found between growth rate (bone scan uptake ratio) and condylar volume difference in patients with vertical type and transverse type CH patients (p = 0.205). Conclusion: Particularly in cases that exhibit a pronounced vertical growth tendency, volumetric and linear measurements can guide the timing and treatment planning process. (c) 2024 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
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    Chymotrypsin and Trypsin Inhibitory Activity of Some Medicinal Plants Collected from Rize (Türkiye)
    (Başkent Üniversitesi Eczacılık Fakültesi, 2024-02-25) Gunbatan, Tugba; Sucu, Melike; Gokbulut, Alper; Dilmac, Elif; Gurbuz, Ilhan
    In this research, the evaluation of in vitro chymotrypsin and trypsin inhibitory activities of ten plant species collected from Rize were aimed, and fractions that showed strong activity were analyzed through HPLC. Daphne pontica L. and Mentha longifolia (L.) L. were found to have the highest chymotrypsin inhibitory activities (87.75 and 84.24 % inhibition). Similarly, the highest trypsin inhibitory activity was observed in D. pontica (%99.93 inhibition), followed by Sambucus ebulus L. flowers (87.47 % inhibition). Extracts showing strong enzyme inhibition were fractioned and subjected to activity tests. The highest chymotrypsin inhibitory activity was observed in the n-hexane fraction of D. pontica (%80.70 inhibition), while the highest trypsin inhibitory activity was found in the n-butanol fraction of S. ebulus (%86.81 inhibition). HPLC studies determined that the 80 % ethanol extract of D. pontica and its dichloromethane and ethyl acetate fractions contained umbelliferone. It was found that chlorogenic acid was present in the 80 % ethanol extracts of S. ebulus flowers. M. longifolia was found to contain chlorogenic acid, caffeic acid, luteolin-7-glucoside, and rosmarinic acid. M. longifolia has been identified as the plant exhibiting the highest antioxidant activity in ABTS and CUPRAC tests, consistent with its high phenolic and flavonoid content.
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    Coeffiinicet Problems For A Certain Subclass Of Analytic And Univalent Functions
    (TURKISH JOURNAL OF MATHEMATICS, 2024-11-26) Altintas, Osman; Mustafa, Nizami
    In the present work, some new subclasses of analytic and univalent functions are introduced and some geometric properties such as coefficient estimates problem are studied for them. Furthermore, we show that our results are generalization for some earlier work in the literature and we show this by comparing ours with those related.
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    Combination Of Miniature Electrode Systems Via Nanomaterials: Pesticide Analysis
    (Başkent Üniversitesi Fen Bilimleri Enstitüsü, 2024-12) Celik, Murat; Kucuk, Ipek; Sadak, Selenay; Uslu, Bengi
    Pesticides are vital in modern agriculture for controlling pests and diseases, thereby enhancing crop yields and food security. However, their extensive use has raised environmental and health concerns due to their persistence and toxicity. Conventional detection methods, such as high-performance liquid chromatography and gas chromatography, are effective but often costly and time-consuming, prompting the need for alternative approaches. Electrochemical methods emerge as promising solutions for pesticide analysis owing to their affordability, simplicity, and suitability for field applications. The incorporation of nanomaterials into electrochemical sensors significantly enhances their sensitivity and selectivity. Nanomaterials, including noble metals, carbon nanotubes, and metal oxide nanoparticles, improve sensor performance through their unique physical, chemical, and biological properties. This review examines recent advancements in miniature electrochemical sensors for pesticide detection, including contemporary literature. It discusses the structure, applications, and impacts of pesticides, and highlights the advantages of electrochemical sensors enhanced by nanomaterials. Various electrode types and their modifications with nanomaterials are evaluated. Additionally, the integration of smartphone technology and innovative approaches such as lab-on-a-chip and portable sensors are explored. By incorporating recent studies, this review provides a comprehensive reference for developing advanced, portable, and in situ analyzers utilizing nanomaterials, aiming to enhance food safety, human health, and environmental monitoring.
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    Comment on "Predictors of Prolonged Teatment Time Intervals in Oral Cavity Cancer"
    (ORAL ONCOLOGY, 2024-01) Topkan, Erkan; Somay, Efsun; Selek, Ugur
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    Comment on 'Accelerated Hypofractionated Chemoradiation For Locally Advanced Head And Neck Cancer During Covid-19 Pandemic: A Tertiary Care Experience'
    (Başkent Üniversitesi Diş Hekimliği Fakültesi, 2024-10-30) Somay, Efsun; Topkan, Erkan; Selek, Ugur; Pehlivan, Berrin
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    Comment on Poor Dental Health as a Risk Factor for Alveolar Ridge Malignancies
    (Başkent Üniversitesi Diş Hekimliği Fakültesi, 2024-03-21) Somay, Efsun; Topkan, Erkan
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    Comment on Poor Dental Health as a Risk Factor for Alveolar Ridge Malignancies
    (Başkent Üniversitesi Diş Hekimliği Fakültesi, 2024-03-21) Somay, Efsun; Topkan, Erkan
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    Comment on Poor Dental Health as a Risk Factor for Alveolar Ridge Malignancies
    (Başkent Üniversitesi Diş Hekimliği Fakültesi, 2024-03-21) Somay, Efsun; Topkan, Erkan
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    Comment On: Risk Prediction Of Complicated Course In Patients Undergoing Major Head And Neck Surgery With Free Fl Ap Reconstruction
    (BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 2024-12) Topkan, Erkan; Somay, Efsun; Ozturk, Duriye; Senyurek, Sukran
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