Sağlık Bilimleri Fakültesi / Faculty of Health Sciences
Permanent URI for this collectionhttps://hdl.handle.net/11727/1402
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Item The Effects of Glucose and Fructose on Body Weight and Some Biochemical Parameters in Rats(2018) Koseler, Esra; Kiziltan, Gul; Turker, Perim Fatma; Saka, Mendane; Ok, Mehtap Akcil; Bacanli, Didem; Aydos, Tolga Resat; Bayraktar, Nilufer; Ozdemir, Handan; 0000-0002-4254-3711; 0000-0002-1832-9336; 0000-0002-7886-3688; AAZ-8170-2020; AAJ-7279-2020; Y-8758-2018Objective: Dietary fructose from added sugar as high fructose corn syrup may causes major risks in obesity, hyperlipidemia, cardiovascular diseases, hyperuricemia and fatty liver. The aim of this study was to investigate and compare the effects of high fructose and high glucose intake on body weight and some biochemical parameters in rats. Subject and methods: The study was conducted on adult, 32 Wistar albino male rats (300-350 g weeks) which fed with standard laboratory chow. In each group, 8 rats was selected randomly and which was be composed four groups. The rats in each group, in addition to standard meal, different amount of glucose and fructose containing solutions (10% and 30% glucose-fed group, 10% and 30% fructose-fed group) was given by oral gavage for 6 weeks. At baseline and after 6 weeks total cholesterol, VLDL-cholesterol, triglycerides, uric acid, AST and ALT as biochemical parameters and liver histopathological examination of rats were determined. Body weight of the rats was evaluated every week. Results: The 30% fructose group caused higher AST levels according to 10% glucose group, 30% glucose group and 10% fructose group. At the end of 6 weeks, the mean body weight in the fructose-fed groups was higher than the glucose-fed groups (p>0.05). No statistically significant difference between rat groups' portal inflammation rates were found and the moderate and severe ballooning were observed in 30% fructose rats (p<0.05). Conclusions: As a result, dietary fructose from added sugar as high fructose corn syrup may causes major metabolic disorders.Item Effects of reproductive and sociodemographic factors on obesity in Turkish women: a pilot study(2019) Bayram, Sinem; Koseler, Esra; Kiziltan, Gul; Ok, Mebtap Akcil; Yesil, Esen; Kose, Beril; Ozdemir, Merve; Muftuoglu, Selen; Saka, Mendane; Aksoydan, Emine; Tayfur, Muhittin; Turker, Perim Fatma; Ercan, Aydan; 0000-0003-1569-7747; 0000-0002-4254-3711; AAF-4491-2021; AAG-6763-2020Background and aim: Obesity has become a global epidemic. The current research aimed to determine sociodemographic and reproductive predictors of obesity among Turkish women. Materials and methods: Eligible subjects (n:833) were 40-64 years-old women living in Turkey. A questionnaire consisted of questions about sociodemographic and reproductive factors and the International Physical Activity Questionnaire were applied to participants by face to face interviews. Multivariate logistic regression examined the risk of being obese with a range of sociodemographic and reproductive factors. All analyses were performed with SPSS software (version 17.0; SPSS, Chicago, Ill., USA). Results: The mean BMI of women aged 51-64 years was 30.59 +/- 6.35 kg/m(2). After adjustments for all other variables, increased obesity risk remained significant in women who had two children, housewifes, minimum active ones, ex smokers and had less than high school education. For multiple regression analysis sociodemographic factors from the bivariate analyses were entered, controlling for menarch age, menopausal age, hormone RT, parity, number of stillbirth, abortion. There was significant association between family income, occupation, education and BMI. Conclusion. In summary these findings showed comparable patterns of association of sociodemographic and reproductive factors with obesity in Turkey. Specific healthy lifestyle counseling is important for decreasing obesity in childbearing age women.