Diş Hekimliği Fakültesi / Faculty of Dentistry

Permanent URI for this collectionhttps://hdl.handle.net/11727/2120

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Subject: search.filters.subject.gingival crevicular fluid

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    Effects of a Cyclic NSAID Regimen on Levels of Gingival Crevicular Fluid Prostaglandin E-2 and Interleukin-1 beta: A 6-month Randomized Controlled Clinical Trial
    (2018) Oduncuoglu, B. F.; Kayar, N. A.; Haliloglu, S.; Serpek, B.; Ataoglu, T.; Alptekin, N. O.; https://orcid.org/0000-0003-0647-9481; https://orcid.org/0000-0003-4104-6462; 29735869; AAQ-4792-2020; G-1816-2014
    Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for inflammation control and pain relief. However, while the adjunct use of NSAIDs is avoided for periodontal therapy because of related side effects, cyclic administration of NSAIDs may reduce or eliminate these effects. We evaluated the effect of a cyclic diclofenac potassium (DP) regimen on clinical parameters and levels of prostaglandin E-2 (PGE(2)) and interleukin-1 beta (IL-1 beta) in the gingival crevicular fluid (GCF) of individuals with periodontitis. Materials and Methods: The study protocol was approved by the Ethics Committee (2000/071). Forty-one individuals with chronic periodontitis (33 men, 8 women) were divided into two groups (test and control) after initial periodontal therapy. During this 6-month, randomized, double-blind, placebo-controlled study, test (n = 28) and control (n = 13) groups were administered a cyclic regimen of DP (50 mg, twice daily) or placebo. Clinical measurements and GCF sample collections were made at baseline, 2, 4, and 6 months. GCF levels of PGE(2) and IL-1 beta were determined using enzyme immunoassay and enzyme-linked immunoassay kits, respectively. Results: At baseline, no significant differences existed between groups for plaque indices, gingival indices, bleeding on probing, probing depth (PD), or attachment levels (P > 0.05). Compared with the control group, cyclic regimen in the test group suppressed increased levels of PGE(2) found in GCF at the end of the study (P < 0.05). Significant differences for PD and relative attachment gain were also noted in favor of the test group (P < 0.05). Conclusions: These results suggest that a cyclic regimen of DP may be efficacious in the management of chronic periodontitis in adults.
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    Gingival crevicular fluid semaphorin 4D and peptidylarginine deiminase-2 levels in periodontal health and disease
    (2019) Veysioglu, Gozde; Savran, Levent; Narin, Figen; Yilmaz, Huriye Erbak; Avsar, Candeger; Saglam, Mehmet; 31025704
    Background The aim of this study was to compare the levels of semaphorin 4D (SEMA4D), peptidylarginine deiminase 2 (PAD2) and matrix metalloproteinase-8 (MMP-8) in gingival crevicular fluid (GCF) in patients with periodontal disease and patients with healthy periodontium and investigate the effects of periodontal treatment on the levels of these molecules. Methods GCF samples were collected from periodontally healthy controls (C group, n = 20), patients with gingivitis (G group, n = 20), and patients with chronic periodontitis (CP group, n = 20). Sampling sites were also divided into bleeding (BP) and non-bleeding (NBP) periodontal pocket groups in CP group. Full-mouth clinical periodontal parameters were also recorded. GCF samplings and clinical records were also repeated at 1 and 3 months after treatment for the CP group. SEMA4D, PAD2, and MMP-8 levels were determined by enzyme-linked immunosorbent assay. Results The GCF SEMA4D, PAD2, and MMP-8 total amounts were similar in CP and G groups (P > 0.05) but significantly greater than the C group (P < 0.05). The GCF SEMA4D and PAD2 total amounts in the BP group were significantly greater than the NBP group (P < 0.05). GCF MMP-8 total amounts were similar in BP and NBP groups (P > 0.05). The GCF SEMA4D, PAD2, and MMP-8 total amounts were significantly reduced at first month after treatment (P < 0.05). There were positive correlations between GCF total amount of SEMA4D and all clinical parameters (P < 0.01) and also between PAD2 and clinical parameters (P < 0.05) except clinical attachment level. There was a positive correlation between GCF total amount of SEMA4D and GCF total amount of MMP-8 (P < 0.05). Conclusions It may be suggested that SEMA4D and PAD2 are related to periodontal disease. Their GCF total amounts may have a diagnostic potential. Additional studies would better clarify their role in periodontal diseases.