Diş Hekimliği Fakültesi / Faculty of Dentistry

Permanent URI for this collectionhttps://hdl.handle.net/11727/2120

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Subject: search.filters.subject.experimental periodontitis

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    Effects of Alpha-Tocopherol on Gingival Expression of Inducible Nitric Oxide Synthase in The Rats with Experimental Periodontitis and Diabetes
    (2016) Hatipoglu, M.; Alptekin, N. O.; Avunduk, M. C.; https://orcid.org/0000-0003-4104-6462; 27251964; G-1816-2014
    Background: The aim of this study was to investigate effects of -tocopherol and/or insulin on the number of gingival inducible nitric oxide synthase (iNOS) positive cells in rats with experimental periodontitis with or without streptozotocin (STZ)-induced diabetes. Materials and Methods: A total of 60 Sprague-Dawley rats were divided into three groups: Group I: The group without diabetes; Group II: The group with STZ-induced diabetes; Group III: The group with STZ-induced diabetes receiving insulin therapy. All animals received anesthesia, and 3/0 silk suture was inserted around the mandibular molar teeth. All groups were divided into subgroups receiving saline (Groups IA, IIA, IIIA) and -tocopherol injection (Groups IB, IIB, IIIB). After a period of 3 weeks, all rats were sacrificed, and the number of gingival iNOS positive cells was analyzed using image analysis software. Results: Applying -tocopherol suppressed the number of gingival iNOS positive cells in Groups IB, IIB, and IIIB compared to application of saline (Groups IA, IIA, and IIIA) (P 0.05). Numbers of gingival iNOS positive cells were found to be similar in the Groups I and III (P 0.05). Conclusions: Within limitations of the current study, this is the first study one may suggest that -tocopherol may reduce oxidative damage in the gingiva of the rats with periodontitis with or without STZ-induced diabetes and increase effects of insulin.
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    Comparison of Two Morphometric Linear Methods to Measure the Alveolar Bone Loss Induced by Experimental Periodontal Disease in Rats
    (2020) Cetin, Mehtap Bilgin; Sezgin, Yasemin
    Objective: The aim of this study was to compare the direct and indirect linear morphometric measurements for the evaluation of alveolar bone loss after experimentally induced periodontitis in rats. Materials and Methods: Right mandibles of 30 Sprague Dawley rats were collected from a previous study which induced periodontitis using ligature model. In direct measurement group, the distance between cementoenamel junction and alveolar bone crest was evaluated by digital caliper and periodontal probe with a dental loop, whereas indirect group measurement was performed by an image analysis program on digital photographs. Results: The difference between groups was determined using Mann-Whitney U test. Average alveolar bone loss was 1.08 +/- 0.22 mm in direct measurement group and 1.19 +/- 0.33 mm inindirect measurement group. The variation between direct and in direct groups was not statistically significant (p>0.05). Conclusion: Based on the present result, it can be concluded that, direct morphometric analysis might be an essential alternative to indirect morphometric evaluations to measure alveolar bone loss after experimentally induced periodontitis in rats.
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    COMPARISON OF TWO MORPHOMETRIC LINEAR METHODS FOR ALVEOLAR BONE LOSS MEASUREMENT IN EXPERIMENTAL PERIODONTITIS
    (2019) Cetin, Mehtap Bilgin; Sezgin, Yasemin
    Aim: The aim of this study was to compare direct (performed by a dental loop, periodontal probe and digital caliper over the alveolar bone) and indirect (performed by means of a special software program on digital photographs) linear morphometric measurements to assess the alveolar bone loss. Material and methods: Thirty right mandible of Sprague Dawley rats were obtained from a previous study that induced periodontitis with ligature model. In direct measurement group, the distance between cemento -enamel junction and alveolar bone crest was evaluated by digital caliper and periodontal probe using a dental loop, whereas in indirect group by an image analysis program on digital photographs. The difference between the groups was determined by Mann-Whitney U test. Results and discussions: Mean alveolar bone loss was 1.08 +/- 0.22 mm in direct measurement group and 1.19 +/- 0.33 mm in indirect measurement group. The difference between direct and indirect groups was not statistically significant (p>0.05). Conclusions: Based on the present result, it can be concluded that, the use of direct morphometric analysis may be an alternative to indirect morphometric evaluations for measuring alveolar bone loss in rats after the induction of experimental periodontitis.