Diş Hekimliği Fakültesi / Faculty of Dentistry

Permanent URI for this collectionhttps://hdl.handle.net/11727/2120

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Start date: 2020End date: 2024

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    Predictive Potential Of Pan-Immune-Inflammation Value / Hemoglobin Index As Biomarker For Osteoradionecrosis Risk In Locally Advanced Nasopharyngeal Carcinomas
    (JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY, 2024-03-27) Yilmaz, Busra; Somay, Efsun; Topkan, Erkan; Pehlivan, Berrin; Besen, Ali Ayberk; Mertsoylu, Huseyin; Selek, Ugur
    Objective: We aimed to investigate whether the Pan-Immune-Inflammation-Value/Hemoglobin (PIV/Hb) index could predict the risk of osteoradionecrosis (ORN) in patients receiving concurrent chemoradiotherapy (CCRT) for locally advanced nasopharyngeal cancer (LA-NPC). Materials and methods: This retrospective analysis included LA-NPC patients who underwent CCRT and preCCRT oral exams at our institution's Departments of Radiation Oncology and Dentistry between January 2010 and December 2022. The relationship between ORN rates and PIV-Hb levels was explored using receiver operating characteristic curve analysis. The primary objective was to establish a correlation between pre-CCRT PIV-Hb levels and ORN rates, while the secondary objective was to identify other risk factors for ORN. Results: Of 249 eligible patients, 21 (8.4 %) were diagnosed with ORN. The optimal pre-CCRT PIV/Hb cutoff was 73.8, which divided patients into two subgroups with distinctive ORN risk estimates: Group 1: PIV/ Hb < 73.8 (N = 206), and Group 2: PIV/Hb >= 73.8 (N = 43). The results of the comparative analysis indicated that the cohort with PIV/Hb >= 73.8 exhibited substantially higher rates of ORN than the PIV/Hb < 73.8 cohort (44.2 % vs. 1.0 %; P < 0.001). The multivariate logistic regression analysis indicated that the pretreatment PIV/ Hb >= 73.8 was independently associated with higher ORN rates (P < 0.001). Conclusion: The results of our current investigation indicate that higher levels of pretreatment PIV/Hb were associated with a significant independent increase in ORN rates in LA-NPC patients who received CCRT. (c) 2024 Elsevier Masson SAS. All rights reserved.
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    Effect Of Ultrasonic And Sonic Instrumentation On Shear Bond Strength Of Resin Composite To Enamel: An In Vitro Study
    (AMERICAN JOURNAL OF DENTISTRY, 2024-04-12) Adiguzel, Ruhsan Muduroglu; Mustafa, Abdelrahman; Oduncuoglu, Bahar Fusun; Colak, Mew Yavuz; Gulsahi, Aye; Arhun, Neslihan
    Purpose: To assess and compare the effects of sonic and ultrasonic instrumentation on shear bond strength (SBS) and investigate the influence of adhesive system application modes (etch&rinse/self-etch) on SBS. Methods: In this experimental study, 45 extracted sound human molars were selected. Mesial and distal surfaces of the teeth were abraded until 90 smooth enamel surfaces were obtained. Specimens were divided into two groups, with half (N= 45) conditioned in etch&rinse mode and the remaining (N= 45) in self-etch mode using Tetric N Bond Universal. Composite resin discs were produced on these surfaces by filling Teflon molds. All specimens were aged via thermocycling. Each group was further divided into three more groups (n= 15) according to the type of periodontal instrumentation (ultrasonic, sonic or none). SBS values were recorded and analyzed using two-way ANOVA. Fracture sites were examined under a stereomicroscope. Results: The type of periodontal instrumentation had no significant effect on SBS values, whether sonic, ultrasonic or their absence (P= 0.945). The type of adhesive system mode had a significant influence on the shear bond strength values. Etch&rinse groups had significantly higher shear bond strength values than self-etch groups (P< 0.001).
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    Comparison Of The Accuracy Of Three Interproximal Reduction Methods Used In Clear Aligner Treatment
    (CLINICAL ORAL INVESTIGATIONS, 2024-01-15) Gulec-Ergun, Pelinsu; Arman-Ozcirpici, Ayca; Atakan-Kocabalkan, Azize; Tuncer, Niluefer Irem
    ObjectivesTo comparatively assess 3 interproximal reduction (IPR) methods used in clear aligner treatment with regard to accuracy, and patient perception of discomfort and anxiety.Materials and methodsA total of 42 patients, treated with the Invisalign (R) system, were included in this prospective trial and received one of the following IPR methods: hand-operated abrasive strips (group 1; 14 patients, 150 teeth), motor-driven 3/4 oscillating segmental discs (group 2; 14 patients, 134 teeth), or motor-driven abrasive strips (group 3; 14 patients, 133 teeth). Accuracy was evaluated using the difference between planned and executed IPR. Anxiety and discomfort levels experienced by the patients were evaluated using a questionnaire of 17 questions.ResultsThe accuracy of IPR was high in groups 2 and 3; however, it was low in group 1 with the executed IPR significantly less than the planned amount. On quadrant-level, executed IPR was significantly less in the upper left quadrant in group 1, and significantly more in the upper right quadrant in group 2. The difference between planned IPR and executed IPR was significant for teeth 11, 21, 32, 33, and 43 in group 1, indicating deficiency. The average difference between planned IPR and executed IPR was 0.08 mm for group 1, 0.09 mm for group 2, and 0.1 mm for group 3. Anxiety and discomfort levels did not differ between the methods, but a negative correlation was observed between age and discomfort and anxiety levels.ConclusionsThe overall accuracy of the 2 motor-driven IPR methods was found to be better than the hand-operated system. Maxillary central incisors and mandibular canines were more prone to IPR deficiency when hand-operated abrasive strips were utilized. Patients were similarly comfortable with all 3 methods, and discomfort and anxiety levels decreased with age.Clinical relevanceMotor-driven methods have proven to be more effective when compared to the hand-operated ones by means of precision, speed, and patient comfort. If the clinician favors a hand-operated method, it may be advised to perform slightly more IPR especially on mandibular canines and maxillary central incisors.
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    Worth Of Pan-Immune-Inflammation Value In Trismus Prediction After Concurrent Chemoradiotherapy For Nasopharyngeal Carcinomas
    (INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS, 2024-01-21) Somay, Efsun; Yilmaz, Busra; Topkan, Erkan; Ozdemir, Beyza Sirin; Ozturk, Duriye; Besen, Ali Ayberk; Mertsoylu, Huseyin; Selek, Ugur
    Objective: Radiation-induced trismus (RIT), one of the rare but serious side effects of concurrent chemoradiotherapy (C-CRT), is difficult to predict with high accuracy. We aimed to examine whether the pretreatment pan-immune-inflammation value (PIV) measures predict RIT in patients with locally advanced nasopharyngeal carcinoma (LA-NPC) receiving C-CRT.Methods: Data of patients with LA-NPC who underwent C-CRT and had maximum mouth openings (MMO) > 35 mm were reviewed. Any MMO of 35 mm or less after C-CRT was considered RIT. All PIV values were computed using the complete blood count test results: PIV = (Platelets x Monocytes x Neutrophils) divided by Lymphocytes. The receiver operating characteristic analysis was employed to dissect a possible association between pre-treatment PIV readings and RIT status. Confounding variables were tested for their independent relationship with the RIT rates using logistic regression analysis.Results: The research comprised 223 participants, and RIT was diagnosed in 46 (20.6%) at a median time from C-CRT to RIT of 10 months (range: 5-18 months). Pre-C-CRT PIV levels and RIT rates were analyzed using receiver operating characteristic curve analysis, with 830 being the optimal cutoff (area under the curve: 92.1%; sensitivity: 87.5%; specificity: 85.5%; Youden index: 0.730). RIT was significantly more prevalent in the PIV > 830 cohort than its PIV <= 830 counterpart (60.3% vs. 5%; hazard ratio 5.79; P < 0.001). Multivariate logistic regression analysis revealed that advanced T-stage (P = 0.004), masticatory apparatus dose V58Gy >=%32 (P = 0.003), and PIV > 830 (P < 0.001) were independently linked with significantly elevated rates of RIT.Conclusion: The presence of elevated pre-C-CRT PIV i
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    The Use of Pre-Chemoradiotherapy Total Masseter Muscle Volume as a Novel Predictor of Radiation-Induced Trismus in Locally Advanced Nasopharyngeal Carcinoma Patients
    (TOMOGRAPHY, 2024-02-07) Somay, Efsun; Topkan, Erkan; Pehlivan, Umur Anil; Yilmaz, Busra; Besen, Ali Ayberk; Mertsoylu, Huseyin; Pehlivan, Berrin; Selek, Ugur
    Background: We sought to determine whether pretreatment total masseter muscle volume (TMMV) measures can predict radiation-induced trismus (RIT) in patients with locally advanced nasopharyngeal carcinoma (LA-NPC) receiving concurrent chemoradiotherapy (C-CRT). Methods: We retrospectively reviewed the medical records of LA-NPC patients who received C-CRT and had pretreatment maximum mouth openings (MMO) greater than 35 mm. MMO of 35 mm or less after C-CRT were considered RIT. We employed receiver operating characteristic (ROC) curve analysis to explore the correlation between pre-treatment TMMV readings and RIT status. Results: Out of the 112 eligible patients, 22.0% of them received a diagnosis of RIT after C-CRT. The optimal TMMV cutoff that was significantly linked to post-C-CRT RIT rates was determined to be 35.0 cc [area under the curve: 79.5%; sensitivity: 75.0%; and specificity: 78.6%; Youden index: 0.536] in the ROC curve analysis. The incidence of RIT was significantly higher in patients with TMMV <= 5.0 cc than in those with TMMV > 35.0 cc [51.2% vs. 8.7%; Odds ratio: 6.79; p < 0.001]. A multivariate logistic regression analysis revealed that pre-C-CRT MMO <= 41.6 mm (p = 0.001), mean masticatory apparatus dose V56.5 >= 34% group (p = 0.002), and TMMV <= 35 cc were the independent predictors of significantly elevated rates of RIT. Conclusion: The presence of a smaller pretreatment TMMV is a reliable and independent novel biological marker that can confidently predict higher RIT rates in LA-NPC patients who receive C-CRT.
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    Toxicities And Prognostic Factors In Elderly HPV-Associated Oropharyngeal Cancer Patients Treated With Radiotherapy Or Chemoradiotherapy
    (JOURNAL OF MEDICAL VIROLOGY, 2024-03-24) Topkan, Erkan; Somay, Efsun; Selek, Ugur
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    Evaluation Of Gap Formation For Different Adhesive Agents In Primary Teeth With Optical Coherence Tomography
    (EUROPEAN ORAL RESEARCH, 2024-05-23) Uyar, Didem Sakaryali; Asena, Leyla; Tirali, Resmiye Ebru
    Purpose This study aimed to evaluate gap formation between the tooth surface and restorative material in terms of microleakage by using optical coherence tomography (OCT) for self-etch and selective-etch applications of two different universal and one self-etch adhesives. Materials and Methods Sixty non-caries, primary molar teeth were divided into six groups; self-etch and selective-etch application ways of two different universal and one self-etch adhesive systems (n:10). After Class-V cavities were prepared, every tooth was distributed randomly in groups to apply adhesion procedure and then, all cavities were restored with polyacid-modified composite resin. Microleakage was evaluated by measuring the gap between the tooth surface and restoration by a blind researcher with Image J Software from OCT images. During statistical analysis, the significance level was accepted as p<0.05. Results According to the statistical analysis of the measurements obtained by Image J Software, selective-etch groups showed less gap formation than self-etch groups for each tested adhesive (p<0.05), and self-etch adhesive without etching showed significantly highest gap formation among all groups (p<0.05). Conclusion Universal adhesives with a selective-etching step might be preferred over self-etch adhesives for long-lasting polyacid-modified composite resin restorations in primary teeth. However, obtained results should be considered with another prospective clinical study for long-term prognosis.
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    The Impact Of Dentofacial Characteristics And Malocclusions On Dissatisfaction With Dentofacial Appearance
    (CLINICAL ORAL INVESTIGATIONS, 2024-11-28) Ince-Bingol, Sinem; Kaya, Burcak
    ObjectivesTo assess how, and to what extent, dentofacial features and malocclusions affect the perceived dissatisfaction with the appearance of dentofacial region in different age groups.Materials and methodsDissatisfaction with dental appearance (DDA) and facial appearance (DFA) of 430 patients were assessed using self-reported 5-point Likert scores (1: very satisfied - 5:very dissatisfied). Number of decayed, filled, and missing teeth, oral hygiene status, crowding in the upper/lower arches, molar relationship, overjet, overbite, posterior-crossbite, upper/lower midline deviations, face type, profile, nasal tip and chin deviations were assessed by an experienced orthodontist. Ordinal logistic regression analysis was performed to determine how the examined variables affected DDA and DFA scores.ResultsThe median age of the 430 patients (271 female, 159 male) was 23.0 years. 60.9% of the patients had Angle Class I, 32.3% had Angle Class II, and 6.7% had Angle Class III molar relationship. According to the IOTN (DC), 37.4% of the patients had grade 4 and grade 5. Gender had no impact on DDA and DFA. Being young (teenagers OR = 4.78, CI:2.43-9.40, young adults (OR = 3.15, CI: 1.70-5.83), having poor oral hygiene (OR = 2.32, CI: 1.37-3.92), missing teeth (OR = 1.19, CI:1.10-1.29), convex profile (OR = 1.94, CI:1.03-3.67), diastema (OR = 3.18, CI:1.33-7.61), crowding in the upper arch (moderate: OR = 2.10, CI:1.30-3.68, severe: OR = 5.94, CI:3.15-11.19) affected the DDA scores negatively. Class III malocclusion (OR = 5.60, CI:1.85-16.91), decreased overbite (OR = 2.44, CI:1.21-4.89), and increase in DDA scores (OR = 1.88, CI: 1.50-2.35) all increased the DFA scores.ConclusionCertain dentofacial characteristics and age of the patients significantly affect self-reported dissatisfaction with dental and facial appearance levels, with varying degrees of severity.Clinical relevanceAwareness of the impacts of malocclusions and dentofacial features that result in patient dissatisfaction among those who apply for dental treatment at the clinic enables a deeper understanding of the patient's priorities, expectations from orthodontic treatment, and satisfaction with the outcome.