Diş Hekimliği Fakültesi / Faculty of Dentistry

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End date: 2019Subject: search.filters.subject.platelet-rich fibrin

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    The Effect of Platelet-Rich Fibrin on Implant Stability
    (2015) Oncu, Elif; Alaaddinoglu, E. Emine; 0000-0001-6718-3882; 26009908; F-3529-2010
    Purpose: Achieving accelerated implant osseointegration could make immediate or early loading of implants more predictable. Platelet-rich fibrin (PRF) is frequently used to accelerate soft and hard tissue healing. The activated platelets in PRF release growth factors, resulting in cellular proliferation, collagen synthesis, and osteoid production. The aim of this study was to compare the stability of dental implants inserted in a one-stage surgical protocol with or without PRF application. Materials and Methods: Twenty healthy patients with adequate alveolar bone and two or more adjacent missing teeth extracted at least 6 months previously were included in this study. A minimum of two tapered implants (Ankylos, Dentsply/Friadent) were placed in each patient. After surgical preparation of the implant sockets, PRF that had been prepared preoperatively was placed randomly into one of the sockets (PRF+). The acellular plasma portion of PRF was used to wet the implant placed into the PRF-coated socket. Resonance frequency measurements were made after implant placement and at 1 week and 1 month postoperatively. Results: Mean implant stability quotients (ISQs) of the PRF+ implants was 69.3 +/- 10.5, and mean ISQs for the PRF-implants was 64.5 +/- 12.2 at the end of the first week. The mean ISQs at 4 weeks postoperatively were 77.1 +/- 7.1 for the PRF+ group and 70.5 +/- 7.7 for the PRF-group. Conclusion: In this study, PRF application increased implant stability during the early healing period, as evidenced by higher ISQ values. Simple application of this material seems to provide faster osseointegration.
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    Effects of Platelet-Rich Fibrin Membrane on Sciatic Nerve Regeneration
    (2018) Bayram, Burak; Akdeniz, Sidika Sinem; Diker, Nurettin; Helvacioglu, Fatma; Erdem, Saban Remzi; 0000-0002-7825-1083; 0000-0002-6026-0045; 0000-0002-7537-2170; 29381631; AAS-4519-2020; AAH-8887-2021; AAJ-2370-2021
    Alternative treatment approaches to improve the regeneration capacity of damaged peripheral nerves are currently under investigation. The objective of the present study was to evaluate the effects of platelet-rich fibrin (PRF) membrane after sciatic nerve crush injury in rabbits by histomorphometric and electromyographic analysis. The left sciatic nerves of 20 male Vienna rabbits were clamped for 30seconds to induce crush injuries. Animals were randomly divided into 2 groups: PRF and control. For each animal in the PRF group, a PRF membrane was wrapped around the injured part of the sciatic nerve to form a tube. No additional treatment was performed in the control group. After a 12-week healing period, tissue samples from the injured nerve region were harvested and the g-ratio of axons, axon density, and impulse transmission changes were evaluated. Analysis revealed that axon density differences were not statistically significant between groups (P=0.139). The rate of nerve fibers with optimum g-ratio was significantly lower in the PRF group than in the control group (P=0.02). Conduction velocity differences between groups were not statistically significant. Although PRF application has previously shown positive regeneration effects on maxillofacial tissues, local PRF membrane application in tube form did not show any histomorphometric or functional improvement in peripheral nerve crush injury recovery.
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    Histological evaluation of combined platelet-rich fibrin membrane and piezo-incision application in orthodontic tooth movement
    (2019) Sar, C.; Akdeniz, S. S.; Ozcirpici, A. Arman; Helvacioglu, F.; Bacanli, D.; 31053517
    The aim of this study was to evaluate the effect of platelet-rich fibrin (PRF) membrane on tooth movement in comparison with shunt control and piezoelectric surgery. Sixteen White Vienna rabbits were included in the study and divided into two groups. Reciprocal forces (20 g) were applied on the maxillary incisors by an orthodontic appliance. In group 1, PRF membrane was placed subperiosteally on the distal alveolar bone surface of the right central incisors and the left side was kept as control. In group 2, piezo-incisions 3 mm in depth were performed and combined with PRF membrane on the distal alveolar bone surface of the right central incisors, while the left side was kept as control. All rabbits were euthanized on day 21 and bilateral alveolar bone segments from the distal regions were removed for histological evaluation. Isolated PRF membrane application increased the blood vessel (8.3 +/- 1.0; P= 0.026), osteoblast (6 +/- 0.8; P= 0.027), and osteoclast (2.3 +/- 0.8; P= 0.026) counts significantly compared to shunt control. Combined application of PRF membrane +piezo-incision increased the blood vessel (15.3 +/- 0.8; P= 0.027), osteoblast (9.8 +/- 1.4; P= 0.026), and osteoclast (3.3 +/- 0.8; P= 0.024) counts significantly compared to shunt control. The increases in blood vessel count and osteoblast cell count were more evident in the combined application group (both P= 0.002). PRF membrane application significantly increased bone turnover, and the combined application of PRF membrane + piezo-incision was found to be the best method for increasing bone turnover.