Diş Hekimliği Fakültesi / Faculty of Dentistry

Permanent URI for this collectionhttps://hdl.handle.net/11727/2120

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Author: search.filters.author.Alptekin, N. O.search.filters.applied.f.language: search.filters.language.eng

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    Effects of Alpha-Tocopherol on Gingival Expression of Inducible Nitric Oxide Synthase in The Rats with Experimental Periodontitis and Diabetes
    (2016) Hatipoglu, M.; Alptekin, N. O.; Avunduk, M. C.; https://orcid.org/0000-0003-4104-6462; 27251964; G-1816-2014
    Background: The aim of this study was to investigate effects of -tocopherol and/or insulin on the number of gingival inducible nitric oxide synthase (iNOS) positive cells in rats with experimental periodontitis with or without streptozotocin (STZ)-induced diabetes. Materials and Methods: A total of 60 Sprague-Dawley rats were divided into three groups: Group I: The group without diabetes; Group II: The group with STZ-induced diabetes; Group III: The group with STZ-induced diabetes receiving insulin therapy. All animals received anesthesia, and 3/0 silk suture was inserted around the mandibular molar teeth. All groups were divided into subgroups receiving saline (Groups IA, IIA, IIIA) and -tocopherol injection (Groups IB, IIB, IIIB). After a period of 3 weeks, all rats were sacrificed, and the number of gingival iNOS positive cells was analyzed using image analysis software. Results: Applying -tocopherol suppressed the number of gingival iNOS positive cells in Groups IB, IIB, and IIIB compared to application of saline (Groups IA, IIA, and IIIA) (P 0.05). Numbers of gingival iNOS positive cells were found to be similar in the Groups I and III (P 0.05). Conclusions: Within limitations of the current study, this is the first study one may suggest that -tocopherol may reduce oxidative damage in the gingiva of the rats with periodontitis with or without STZ-induced diabetes and increase effects of insulin.
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    Effects of a Cyclic NSAID Regimen on Levels of Gingival Crevicular Fluid Prostaglandin E-2 and Interleukin-1 beta: A 6-month Randomized Controlled Clinical Trial
    (2018) Oduncuoglu, B. F.; Kayar, N. A.; Haliloglu, S.; Serpek, B.; Ataoglu, T.; Alptekin, N. O.; https://orcid.org/0000-0003-0647-9481; https://orcid.org/0000-0003-4104-6462; 29735869; AAQ-4792-2020; G-1816-2014
    Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for inflammation control and pain relief. However, while the adjunct use of NSAIDs is avoided for periodontal therapy because of related side effects, cyclic administration of NSAIDs may reduce or eliminate these effects. We evaluated the effect of a cyclic diclofenac potassium (DP) regimen on clinical parameters and levels of prostaglandin E-2 (PGE(2)) and interleukin-1 beta (IL-1 beta) in the gingival crevicular fluid (GCF) of individuals with periodontitis. Materials and Methods: The study protocol was approved by the Ethics Committee (2000/071). Forty-one individuals with chronic periodontitis (33 men, 8 women) were divided into two groups (test and control) after initial periodontal therapy. During this 6-month, randomized, double-blind, placebo-controlled study, test (n = 28) and control (n = 13) groups were administered a cyclic regimen of DP (50 mg, twice daily) or placebo. Clinical measurements and GCF sample collections were made at baseline, 2, 4, and 6 months. GCF levels of PGE(2) and IL-1 beta were determined using enzyme immunoassay and enzyme-linked immunoassay kits, respectively. Results: At baseline, no significant differences existed between groups for plaque indices, gingival indices, bleeding on probing, probing depth (PD), or attachment levels (P > 0.05). Compared with the control group, cyclic regimen in the test group suppressed increased levels of PGE(2) found in GCF at the end of the study (P < 0.05). Significant differences for PD and relative attachment gain were also noted in favor of the test group (P < 0.05). Conclusions: These results suggest that a cyclic regimen of DP may be efficacious in the management of chronic periodontitis in adults.