Computational Prediction of MicroRNA Function and Activity
Abstract
Inferring microRNA (miRNA) functions and activities has been extremely important to understand their system-level roles and the mechanisms behind the cellular behaviors of their target genes. This chapter first details methodologies necessary for prediction of function and activity. It then introduces the computational methods available for investigation of sequence and experimental data and for analysis of the information flow mediated through miRNAs.
Description
Keywords
Regulatory networks, Transcriptional modules, Biclustering, Bipartite graphs, Multiway analysis