TR-Dizin İndeksli Açık & Kapalı Erişimli Yayınlar

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Author: search.filters.author.Ozbek, Ozlem Yilmaz

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    Effect of Obesity on Pulmonary Function in Children with Mild Persistent Asthma
    (2016) Koksal, Burcu Tahire; Ozbek, Ozlem Yilmaz; 0000-0001-9580-7656; AAF-2109-2021
    Objective: The prevalence of asthma is increased in obese individuals. There is no concrete evidence that an increase in body mass index is associated with a loss of pulmonary function in childhood asthma. Our aim was to investigate the effect of obesity, atopy, and sex on pulmonary function in asthmatic children. Materials and Methods: This study is a cross-sectional analysis in children with mild persistent asthma. A total of 76 obese and 55 lean children with asthma were recruited. All of the participants were assessed by pulmonary function tests. Skin prick tests including common aeroallergens were performed to all patients. Results: No differences were found in pulmonary function test parameters between obese and lean patients with asthma. In obese patients with asthma, the ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC) was significantly lower in nonatopic (92.1+/-6.4) than in atopic patients (95.5+/-5.3, p=0.02). We also demonstrated that FEV1/FVC was significantly lower in nonatopic obese patients (92.1+/-6.4) than in nonatopic lean patients with asthma (95.6+/-4.7, p=0.05). Conclusion: Obesity does not seem to be affecting pulmonary function in children with well-controlled mild persistent asthma. However, airways of nonatopic obese asthmatics are negatively affected.
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    A single-center experience of post-transplant lymphoproliferative disorder (PTLD) cases after pediatric liver transplantation: Incidence, outcomes, and association with food allergy
    (2018) Haberal, Mehmet; Haberal, Nihan; Baris, Zeren; Ozcay, Figen; Ozbek, Ozlem Yilmaz; Sarialioglu, Faik; 29755021; AAB-4153-2020
    Background/Aims: We evaluated our 16-year single-center experience of pediatric post-transplant lymphoproliferative disorder (PTLD) cases who underwent liver transplantation between 2001 and 2017. Materials and Methods: Of the 236 pediatric patients who underwent liver transplantation between 2001 and 2017, the clinical and laboratory data of eight patients diagnosed with PTLD were reviewed. The pre-transplant Epstein-Barr virus (EBV) status of 172 patients was also recorded. Results: The total incidence of PTLD was 3.4%. The incidence of PTLD was 10% in pre-transplant EBV immunoglobulin G (IgG)-seronegative patients and 0.8% in pre-transplant EBV IgG-seropositive patients. The mean age of the patients at liver transplantation was 2.71 +/- 3.21 years, and four patients were aged below 1 year at the time of transplantation. PTLD was diagnosed at 21.81 +/- 18.1 months after transplantation. The primary site of involvement was variable among patients: peripheral and mediastinal lymph nodes, stomach and intestine, transplanted graft, bone marrow, and nasopharynx. The eosinophil count varied greatly among patients, with a mean value of 524.62 +/- 679/mm3. Three patients had a food allergy and were administered an elimination diet at the time of PTLD diagnosis. Six patients had PTLD of B-cell origin. One patient died due to neutropenic sepsis during chemotherapy, whereas seven patients were followed up in full remission for 7.75 +/- 4 years. Conclusion: PTLD is a life-threatening complication of solid-organ transplantation with a heterogeneous clinical spectrum. Food allergy had a close association with PTLD. A close follow-up of patients with risk factors and an early diagnosis with appropriate treatment may lead to a better outcome.