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Item Treatment Outcomes of Breast Cancer Liver Metastasis Treated with Stereotactic Body Radiotherapy(2018) Onal, Cem; Guler, Ozan Cem; Yildirim, Berna Akkus; https://orcid.org/0000-0002-2742-9021; https://orcid.org/0000-0001-6908-3412; https://orcid.org/0000-0001-6661-4185; 30296648; HOC-5611-2023; AAC-5654-2020; V-5717-2017Background: To assess the outcomes of breast cancer liver metastasis (BCLM) treated with stereotactic body radiotherapy (SBRT) and systemic treatment. Materials and methods: Patients with oligometastasis at the time of liver metastasis (LM) or who became oligometastatic (<= 5 metastases) after systemic treatment were assessed. Twenty-nine liver metastatic lesions were treated with a total of 54 Gy delivered in 3 fractions. The local control (LC), overall survival (OS), and progression-free survival (PFS) rates were calculated using Kaplan-Meier analyses. Results: A total of 22 patients with 29 liver metastatic lesions treated with liver SBRT between April 2013 and September 2017 were retrospectively analyzed. After a median follow-up time of 16.0 months (range 4.4-59.4 months), 18 patients (82%) had disease recurrence, median of 7.4 months (range 1.0-27.9 months) after completion of liver SBRT. The 1- and 2-year OS rates were 85% and 57%, and the 1- and 2-year PFS rates were 38% and 8%, respectively. The 1- and 2-year LC rates were 100% and 88%, respectively. No significant prognostic factors, including disease extension, size of metastasis, number of liver metastasis and timing of liver metastasis, hormonal status affecting OS, PFS and LC were found. No patients experienced Grade 4 or 5 toxicity; furthermore, only one patient experienced rib fracture 6 months after completion of treatment, and one patient had a duodenal ulcer. Conclusion: This study is the first to evaluate the feasibility of SBRT to BCLM patients. Liver SBRT is a conservative approach with excellent LC and limited toxicities. (C) 2018 Elsevier Ltd. All rights reserved.Item Clinicohistopathological Features and Treatment Outcomes of Neuroendocrine Tumors; A Single Center Experience(2017) Sumbul, A. T.; Sedef, A. M.; Kose, F.; Mertsoylu, H.; Sezer, A.; Ozyilkan, O.; Abali, H.; https://orcid.org/0000-0002-5573-906X; https://orcid.org/0000-0001-8825-4918; D-4793-2014; AAD-2817-2021Item Early Postoperative Acute Kidney Injury Among Pediatric Liver Transplant Recipients(2018) Sahinturk, Helin; Kundakci, Aycan; Zeyneloglu, Pinar; Gedik, Ender; Pirat, Arash; Haberal, Mehmet; 0000-0003-0159-4771; 0000-0002-7175-207X; 0000-0002-3462-7632; AAJ-1419-2021; AAH-7003-2019; ABI-2971-2020; AAJ-8097-2021Item Solving A Nonhomogeneous Linear System of Interval Differential Equations(2018) Gasilov, Nizami A.; Amrahov, Sahin Emrah; AAN-9386-2020In most application problems, the exact values of the input parameters are unknown, but the intervals in which these values lie can be determined. In such problems, the dynamics of the system are described by an interval-valued differential equation. In this study, we present a new approach to nonhomogeneous systems of interval differential equations. We consider linear differential equations with real coefficients, but with interval initial values and forcing terms that are sets of real functions. For each forcing term, we assume these real functions to be linearly distributed between two given real functions. We seek solutions not as a vector of interval-valued functions, as usual, but as a set of real vector functions. We develop a method to find the solution and establish an existence and uniqueness theorem. We explain our approach and solution method through an illustrative example. Further, we demonstrate the advantages of the proposed approach over the differential inclusion approach and the generalized differentiability approach.Item The Approach to Community-Acquired Pneumonia: A Survey Study(2018) Ozyurek, Berna Akinci; Erturk, Arzu; Aydemir, Yusuf; Sen, Nazan; Alizoroglu, Dursun; Ozhan, Mustafa Hikmet; https://orcid.org/0000-0002-4171-7484; AAI-8947-2021INTRODUCTION AND AIM: Community-acquired pneumonia (CAP), which is often seen in daily practice, is a lower respiratory tract and pulmonary parenchyma infection which develops in society and daily life with community-acquired pathogens in individuals with no known immune failure. Delay in the treatment of pneumonia is known to increase morbidity and mortality. Various scoring systems are currently used in the identification of treatment groups in pneumonia. With the aim of evaluating the approach to CAP cases, the infection. MATERIALS AND METHODS: Working Group of the Turkish Respiratory Research Association (TUSAD) prepared a 22-item questionnaire. RESULTS: The survey was published on the TUSAD official website between July 2013 and June 2016. A total of 78 individuals responded to the questionnaire on the website. CONCLUSION: The responses to the questionnaire could indicate the way forward for new guidelines for physicians in respect of the approach to CAP.Item Comparable Survival Using A CMV-Matched Or A Mismatched Donor For CMV Plus Patients Undergoing T-Replete Haplo-HSCT With PT-Cy For Acute Leukemia: A Study Of Behalf Of The Infectious Diseases And Acute Leukemia Working Parties Of The EBMT(2018) Cesaro, Simone; Crocchiolo, Roberto; Tridello, Gloria; Knelange, Nina; Van Lint, Maria Teresa; Koc, Yener; Ciceri, Fabio; Gulbas, Zafer; Tischer, Johanna; Afanasyev, Boris; Bruno, Benedetto; Castagna, Luca; Blaise, Didier; Mohty, Mohamad; Irrera, Giuseppe; Diez-Martin, J. L.; Pierelli, Luca; Pioltelli, Pietro; Arat, Mutlu; Delia, Mario; Fagioli, Franca; Ehninger, Gerhard; Aljurf, Mahmoud; Carella, Angelo Michele; Ozdogu, Hakan; Mikulska, Malgorzata; Ljungman, Per; Nagler, Arnon; Styczynski, Jan; https://orcid.org/0000-0002-8902-1283; 29330396; AAD-5542-2021The role of donor CMV serostatus in the setting of non T-cell depleted haplo-HSCT with post-transplant cyclophosphamide (PT-Cy) has not been specifically addressed so far. Here we analyzed the impact of the donor CMV serological status on the outcome of 983 CMV seropositive (CMV+), acute leukemia patients receiving a first, non T-cell depleted haplo-HSCT registered in the EBMT database. The 1-year NRM was 21.3% (95% CI: 18.4-24.8) and 18.8% (95% CI: 13.8-25.5) in the CMV D+P/R+ and D-/R+ pairs, respectively (p = 0.40). Similarly, 1-year OS was 55.1% (95% CI: 50.1-58.0) and 55.7% (95% CI: 48.0-62.8) in the same groups (p = 0.50). The other main outcomes were comparable. No difference in NRM nor OS was observed after stratification for the intensity of conditioning and multivariate anaysis confirmed the lack of significant association with NRM or OS. In conclusion, the choice of a CMV-seronegative donor did not impair early survival of CMV-seropositive patients with acute leukemia after a first, non T-cell depleted haploidentical HSCT and PT-Cy among this series of 983 consecutive patients. Future research may focus on the assessment of the hierarchy of all the donor variables.Item Bilgisayar Programlama Derslerinde Öğrenme Motivasyonu Ölçeğinin Türkçe Uyarlaması: Geçerlilik ve Güvenilirlik Çalışması(Başkent Üniversitesi Eğitim Bilimleri Fakültesi, 2018) Avcı, Ummuhan; Ersoy, Halil; 0000-0001-7007-1478; 0000-0003-1598-7656Bu araştırmanın amacı Law, Lee ve Yu 2010 tarafından geliştirilen Bilgisayar Programlama Derslerinde Öğrenme Motivasyonu Ölçeği’ni Türkçe’ye uyarlamaktır. Bu amaçla geçerlik ve güvenirlik analizlerini yapmak üzere altı faktör bireysel tutum ve beklenti, zorlayıcı amaçlar, belirgin hedefler, ödül ve takdir, ceza, sosyal baskı ve rekabet ve 19 maddeden oluşan altılı Likert tipindeki ölçek, özel bir üniversitede okuyan 312 mühendislik fakültesi öğrencisine uygulanmıştır. Doğrulayıcı faktör analizi sonuçları incelendiğinde, ölçeğin altı faktörden oluştuğu doğrulanmış ve ölçeğin uyum iyiliği indislerinin yeterli düzeyde olduğu görülmüştür. Ölçeğin güvenilirliği Cronbach alfa iç tutarlılık katsayısı ile değerlendirilmiştir. Cronbach alfa katsayısının ölçeğin tamamında 0.90 olduğu ve faktörler bazında 0.71 ile 0.83 arasında değiştiği görülmüştür. Bu sonuçlar ölçeğin, bilgisayar programlama derslerinde öğrenme motivasyonunun ölçülmesinde geçerli ve güvenilir bir ölçme aracı olduğunu göstermektedir. The aim of this study is to adapt the Learning Motivation in Computer Programming Courses Scale developed by Law, Lee ve Yu 2010 to Turkish. In order to determine its validity and reliability, the scale consisting of 19 six-point Likert-type items within six factors individual attitude and expectation, challenging goals, clear direction, reward and recognition, punishment and social pressure and competition was applied to 312 engineering faculty students at a private university. When the results of the confirmatory factor analysis were examined, it was confirmed that the scale had six factors, and the goodness of fit indices are at an acceptable degree. The reliability of the scale was assessed by the Cronbach alpha internal consistency coefficient. The Cronbach’s alpha coefficiencies were found to be 0.90 for the whole scale and between 0.71 and 0.83 for the factors. These results show that scale is a valid and reliable measuring tool for learning motivation in computer programming coursesItem Yükseköğretimde Uzaktan Eğitim Uygulamalarının İncelenmesi: Türkiye Örneği(Başkent Üniversitesi Eğitim Bilimleri Fakültesi, 2017) Cabi, Emine; Ersoy, Halil; 0000-0002-7488-0309; 0000-0003-1598-7656Bu çalışma 2010 yılından 2016 yılına kadar, Türkiye yükseköğretiminde uzaktan eğitim çalışmalarının sayısal veriler ışığında incelenmesini amaçlamaktadır. 2010 ile 2016 yılları arasındaki yükseköğretimdeki öğrenci sayıları, uzaktan eğitim veren ön lisans, lisans ve yüksek lisans programlarına yerleşen öğrenci sayıları ve mevcut program sayılarının dağılımları incelenmiştir. Ön lisans ve lisans seviyesinde 20102015 arası uzaktan eğitimde öğrenim gören öğrenci sayılarına ulaşılabilirken, yüksek lisans seviyesinde sadece 2014-2015 ve 2015-2016 eğitim-öğretim dönemlerindeki program ve öğrenci sayılarına ulaşılabilmiştir. Ayrıca çalışmada genel ve programlara yerleşen öğrenci sayılarının yıllara göre değişimleri de incelenmiştir. Yapılan çalışma durum çalışması olduğundan mevcut durumu boylamsal olarak ortaya koymaktadır. Bu bağlamda, yeni açılması düşünülen uzaktan eğitim programlarının yapılandırılması çalışmalarında katkısı olabileceği düşünülmektedir. This study aims to investigate distance education implementations in higher education of Turkey from 2010 to 2016 by numeric data. For this purpose, the numbers and distribution of students at vocational schools, undergraduate and graduate level programs being executed totally in distance education method were analyzed. While it was possible to reach to the numbers of distant students at vocational schools and undergraduate levels between 2010 and 2015, only 2014-2015 and 2015-2016 years’ data were been able to obtained at graduate level. Moreover, the change in the numbers of distant students by years was investigated. Hence it is a case study, it portrays the existing situation longitudinally. In this context, it is believed that the study will contribute to the actions targeting to open new distance education programsItem Understanding the Effect of Assignment of Importance Scores of Evaluation Criteria Randomly in the Application of DOE-TOPSIS in Decision Making(2019) Ic, Yusuf Tansel; Yurdakul, Mustafa; 0000-0001-9274-7467; AGE-3003-2022In conventional applications of hybrid DoE-TOPSIS technique in decision making problems, full factorial design layouts are generally used because of their ability to measure the effects of all possible combinations for evaluation factors. In a typical application, for a design layout, a number of replications are generated by assigning different sets of relative importance scores for evaluation factors. A TOPSIS score is then obtained for each experiment and replication pair. Regression analysis is finally applied to obtain a relationship with inputs (values of evaluation factors) and outputs (alternatives' TOPSIS meta-model scores). The key in conventional application of hybrid DoE-TOPSIS technique is generation of relative importance scores. Each set of scores can be assigned by a decision maker or generated randomly. This paper aims to determine whether using either of the two methods in determination of relative importance scores makes any difference in the ranking orders of alternatives.Item Gold nanocomposites for biomedical applications(2019) Akturk, Omer; Erdemli, Ozge; Tunali, Beste Cagdas; 0000-0001-8606-8863; AAF-4496-2019; AAG-3927-2019