Meslek Yüksek Okulları / Vocational Schools
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Item The influence of vitamin d3 treatment on the risk of development of acute rejection, epithelial-mesenchymal transition (EMT), and interstitial fibrosis among pediatric renal transplant patients(2019) Ozdemir, B. Handan; Baskin, Esra; Ozdemir, F. Nurhan; Akcay, Eda Yilmaz; Moray, Gokhan; Haberal, Mehmet; 0000-0003-4361-8508; B-5785-2018Item The importance of age and CD4/CD8 ratio on the presenting time and the prognosis of the polyoma virus associated nephropathy (PVAN) after renal transplantation(2019) Ozdemir, B. Handan; Ozdemir, F. Nurhan; Baskin, Esra; Atilgan, Alev Ok; Moray, Gokhan; Haberal, Mehmet; 0000-0003-4361-8508; B-5785-2018Item EFFECT OF LIVER TRANSPLANTATION ON NEUROLOGICAL MANIFESTATIONS AND BRAIN MAGNETIC RESONANCE IMAGING FINDINGS IN WILSON DISEASE(2019) Soy, Ebru H. Ayvazoglu; Ocal, Ruhsen; Benli, Sibel; Donmez, Fuldem; Agildere, Muhtesem; Ocal, Serkan; Haberal, Mehmet; 0000-0002-0993-9917; AAC-5566-2019; AAB-5802-2020Item CYTOMEGALOVIRUS (CMV) INFECTION INDUCES AN ANGIOGENIC RESPONSE THROUGH HEPATIC STELLATE CELLS (HSCS) AND LEADS TO EARLY POST-TRANSPLANT LIVER FIBROSIS (LF) AND POOR GRAFT SURVIVAL(2019) Ozdemir, B. Handan; Ozgun, Gonca; Soy, Ebru H. Ayvazoglu; Haberal, Nihan; Moray, Gokhan; Haberal, Mehmet; 0000-0002-0993-9917; AAC-5566-2019Item ENDOTHELIAL CELL CYTOSKELETON REARRANGEMENT (ECCSKR) AND ENDOTHELIAL TO MESENCHYMAL TRANSITION (ENDOMT) IN LIVER ALLOGRAFTS FOLLOWING ACUTE REJECTION: IT'S SIGNIFICANCE ON THE LIVER FIBROSIS(2019) Ozdemir, B. Handan; Ozgul, Gonca; Soy, Ebru H. Ayvazoglu; Akdur, Aydincan; Haberal, Nihan; Moray, Gokhan; Haberal, Mehmet; 0000-0002-0993-9917; AAC-5566-2019Item THE IMPACT OF INVERTED RENAL CD4/CD8 RATIO IN THE FIRST 3-MONTH BIOPSIES POST-TRANSPLANT ON THE DEVELOPMENT OF TRANSPLANT GLOMERULOPATHY AND VASCULOPATHY IN RENAL ALLOGRAFTS(2019) Ozdemir, Handan B.; Ozdemir, Nurhan F.; Atilgan, Alev Ok; Akcay, Eda; Kirna, Mahir; Haberal, Mehmet; AAH-9198-2019Item WHAT IS THE ROLE OF ENDOTHELIAL-TO-MESENCHYMAL TRANSITION (ENDOMT) OF RENAL CAPILLARIES ON THE RENAL OUTCOME BOTH IN ISOLATED TRANSPLANT GLOMERULOPATHY AND CHRONIC ANTIBODY-MEDIATED REJECTION (CAMR)(2019) Ozdemir, B. Handan; Ozdemir, F. Nurhan; Akdur, Aydincan; Kirnap, Mahir; Moray, Gokhan; Haberal, Mehmet; AAH-9198-2019Item Effect of Graft Weight to Recipient Body Weight Ratio on Hemodynamic and Metabolic Parameters in Pediatric Liver Transplant: A Retrospective Analysis(2017) Haberal, Mehmet; Ersoy, Zeynep; Kaplan, Serife; Ozdemirkan, Aycan; Torgay, Adnan; Arslan, Gulnaz; Pirat, Arash; 0000-0003-0767-1088; 0000-0002-6829-3300; 0000-0002-3462-7632; 28260433; AAF-3066-2021; AAJ-5221-2021; AAJ-8097-2021; AAH-7003-2019Objectives: To analyze how graft-weight-to-body-weight ratio in pediatric liver transplant affects intraoperative and early postoperative hemodynamic and metabolic parameters. Materials and Methods: We reviewed data from 130 children who underwent liver transplant between 2005 and 2015. Recipients were divided into 2 groups: those with a graft weight to body weight ratio > 4% (large for size) and those with a ratio <= 4% (normal for size). Data included demographics, preoperative laboratory findings, intraoperative metabolic and hemodynamic parameters, and intensive care follow-up parameters. Results: Patients in the large-graft-for-size group (>4%) received more colloid solution (57.7 +/- 20.1 mL/kg vs 45.1 +/- 21.9 mL/kg; P = .08) and higher doses of furosemide (0.7 +/- 0.6 mg/kg vs 0.4 +/- 0.7 mg/kg; P = .018). They had lower mean pH (7.1 +/- 0.1 vs 7.2 +/- 0.1; P = .004) and PO2 (115.4 +/- 44.6 mm Hg vs 147.6 +/- 49.3 mm Hg; P = .004) values, higher blood glucose values (352.8 +/- 96.9 mg/dL vs 262.8 +/- 88.2 mg/dL; P < .001), and lower mean body temperature (34.8 +/- 0.7 degrees C vs 35.2 +/- 0.6 degrees C; P = .016) during the neohepatic phase. They received more blood transfusions during both the anhepatic (30.3 +/- 24.3 mL/kg vs 18.8 +/- 21.8 mL/kg; P = .013) and neohepatic (17.7 +/- 20.4 mL/kg vs 10.3 +/- 15.5 mL/kg; P = .031) phases and more fresh frozen plasma (13.6 +/- 17.6 mL/kg vs 6.2 +/- 10.2 mL/kg; P = .012) during the neohepatic phase. They also were more likely to be hypotensive (P < .05) and to receive norepinephrine infusion more often (44% vs 22%; P < .05) intra-operatively. More patients in this group were mechanically ventilated in the intensive care unit (56% vs 31%; P = .035). There were no significant differences between the groups in postoperative acute renal dysfunction, graft rejection or loss, infections, length of intensive care stay, and mortality (P > .05). Conclusions: High graft weight-to-body-weight ratio is associated with adverse metabolic and hemodynamic changes during the intraoperative and early postoperative periods. These results emphasize the importance of using an appropriately sized graft in liver transplant.Item Zea Mays'dan Endofitik ve Ksilanolitik Bacillus Pumilus Suşlarının İzolasyonu(Ankara Üniversitesi Ziraat Fakültesi Tarım Bilimleri Dergisi ,14 ,4 ,374-380, 2008) Yaşınok, Ayşegül Ersayın; Şahin, Feride İffet; Haberal, MehmetBu çalışmada, yüzey sterilizasyonu yapılmış Zea mays gövde ve yapraklarından, sırası ile M1 ve M2 olarak isimlendirilen iki tane endofitik ksilanolitik bakteri izole edilmiştir. Izolatlar Bacillus pumilus olarak tanımlanmıştır. Mikroorganizmalar agar üzerinde farklı morfoloji sergilemiştir. Izolatlar arasında, ksilanaz üretim seviyesi ve profilinde de farklılıklar bulunmaktadır. İçinde %3 mısır koçanını tek karbon kaynağı olarak bulunduran sıvı besi yerinde, Bacillus pumilus M1 ve Bacillus pumilus M2 sırası ile maksimum ksilanaz aktivitesi olan 188.0 ± 20.0 ve 5.6 ± 1.1 U/ml değerlerine ulaşabilmiştir. İzolatlar, kaba fermentasyon özütünde çok düşük miktarda selülaz üretmiştir. B. pumilus M1 ksilanazı kısmi karakterize edilmiştir. Enzim pH 8.0 ve 65°C'de maksimum aktivite götermiş, kağıt beyazlatma endüstrisine uygun görülmüş ve ileri derecede karakterizasyona ihtiyaç duymuştur. Sonuç olarak, bu çalışma Zea mays'ın iç kısmının, ksilanaz üreticilerinin izolasyonu için yeni ve iyi bir kaynak olduğunu göstermiştir. Detaylı tanımlama ardından bu enzimler, kağıt, tekstil, gıda ve yem endüstrisinde çeşitli uygulamalarda değerlendirilebilmesi mümkündür. In this study, two endophytic xylanolytic bacteria, named M1 and M2, were isolated from surface sterilized Zea mays stem and leaf, respectively. Isolates were identified as Bacillus pumilus. Microorganisims showed different morphology on agar plates. Xylanase production level and profile varied between isolates, as well. Maximum xylanase production level of 188.0 ± 20.0 and 5.6 ± 1.1 U/ml were achieved by Bacillus pumilus M1 and Bacillus pumilus M2 in a liquid medium containing 3% corn cobs as a sole carbon source and inducer, respectively. Isolates produced very low level of cellulase in crude enzyme extract. B. pumilus M1 xylanase was partially characterized. Enzyme had a maximum activity at pH 8.0 and 65°C, seemed proper for pulp and paper industry, and required further characterization. In conclusion, this study indicated that inside part of Zea mays is a novel and good source for isolating xylanase producers. After detailed characterization, such enzymes could be used in various applications in paper and pulp, textile, food and feed industries.