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    Impact of Rho-Kinase Inhibitor Hydroxyfasudil in Protamine Sulphate Induced Cystitis Rat Bladder
    (2015) Akin, Yigit; Bozkurt, Aliseydi; Erol, Huseyin S.; Halici, Mesut; Celebi, Fikret; Kapakin, Kubra A. T.; Gulmez, Hakan; Ates, Mutlu; Coban, Abdulkadir; Nuhoglu, Baris; 0000-0001-5467-3743; 26663691; Y-1659-2019
    ObjectivesThe objective of the present study was to evaluate anti-inflammatory effects of hydroxyfasudil in a protamine sulfate (PS) induced cystitis rat model. Additionally, we investigated prevention of bladder overactivity (BO), and tissue damage in these experiments. MethodsAnimals were divided into four groups. In Groups 1 and 2, chemical induced cystitis model was created by administrating intravesical PS with PE50 catheter by the transurethral route. In Group 1, Rho-kinase inhibitor hydroxyfasudil was administered intaperitoneally, and in Group 2, subjects were administered a corresponding volume of saline in the same way. In Group 3, vehicle was administered intravesically and hydroxyfasudil was administrated intraperitoneally. Group 4 was a control Group, and the vehicle was administered intravesically and intraperitoneally. Micturition frequencies were recorded. Biochemical analyses were performed for oxidative stress, and pathological evaluations were investigated. In vitro contractions of bladder tissue strips were measured in tissue-bath. ResultsThere were significantly lower Lipid peroxidase levels and higher levels of Glutathione in Group 1 than Group 2 (P=0.016, P=0.001, respectively). There was generally more inflammation in Group 2 than the other groups as determined by microscopy. There were significantly higher frequencies of micturition, lower volume, and mean voided maximum urine output after PS administration in Groups 1 and 2. In vitro contraction responses of bladder strips to potassium chloride and acetylcholine were statistically higher in Group 2 than Groups 1 and 3. ConclusionsSignificant reduction of inflammation by affecting the anti-oxidant defense systems was provided by hydroxyfasudil. Decreased in vitro responses to contractions of bladder smooth muscle strips were obtained. Hydroxyfasudil may be a potential new therapeutic option for inflammation and BO, in rat bladder.
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    TURKISH-COFFEE ENRICHED WITH ROSE: A PROMISING COMBINATION
    (2019) Karabudak, E.; Aksoydan, E.; Agagunduz, D.; Ergul, M.
    The purpose of this study was to develop a new & healthy version of Turkish-coffee enriched with rose. Conventionally roasted Coffee Arabica L. beans for Turkish-coffee & dried-Rosa Damascene Mill. [7 / 0,7 / 0.5,7 / 1.5,7 / 2g(w / w)] was grinded. Total-Phenolic Contents (TPC), Total-Antioxidant (TAS) & Oxidant-Status (TOS) were measured and Oxidatif Stress Index (OSI) was calculated. Consumer panel testing was done. TPC of the coffee samples with 1.5 & 2g rose was different according to plain coffee (p<0.05). TAS value (mmol/L) of plain-coffee was 2.2 +/- 0.11 while the values of the coffees including 0.5g,1.5g,2g rose were 2.4 +/- 0.09,2.4 +/- 0.05,2.7 +/- 0.02, respectively. TOS value (mu mol/L) of plain-coffee was 17.6 +/- 0.24, while the values of the coffees including 0.5 g, 1.5 g and 2 g rose were 13.0 +/- 1.00, 9.4 +/- 1.30, 9.4 +/- 0.31, respectively (p<0.05). OSIs of coffee samples including 0, 0.5, 1.5, 2 g rose were found to be 7.7, 5.2, 3.6, 2.7 respectively (p<0.05). The coffees including 1.5 & 2 g rose had the highest sensory-scores. Turkish-coffee including rose will strengthen already existing phenolic & antioxidant features of coffee, and thus contribute the improvement of health & taste.