Fakülteler / Faculties
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Item Plasma GDF-15 Levels and Their Association with Hormonal and Metabolic Status in Women with Polycystic Ovary Syndrome Aged 25-35(2014) Berberoglu, Z.; Aktas, A.; Fidan, Y.; Yazici, A. Canan; Aral, Y.; https://orcid.org/0000-0002-3132-242X; 24736483; AAS-6810-2021Aim. We aimed to determine plasma levels of growth differentiation factor (GDF)-15 and their possible association with hormonal and metabolic status, as well as echocardiographic profiles and carotid artery intima-media thickness (CAIMT) measurements in patients with polycystic ovary syndrome (PCOS). Methods. Forty-two obese PCOS women aged 25-35 years, 23 women with idiopathic hirsutism and 20 healthy controls matched for age and body mass index were enrolled. Anthropometric, metabolic and hormonal patterns, plasma GDF-15 concentrations, CAIMT, and conventional echocardiographic parameters were measured. Results. Metabolic/lipid profiles as well as GDF-15 levels were similar across the three groups. CAIMT tended to be higher in PCOS group but did not reach statistical significance. No between-group differences were found in the conventional echocardiographic parameters. Analysis of PCOS patients showed a significant correlation of GDF-15 concentrations with age and homeostasis model assessment (HOMA) index (r=0.319, P<0.05, and r=0.312, P<0.05, respectively). In multiple linear regression analyses, GDF-15 was significantly associated with age (r(2)=0.102, P<0.05), and HOMA index (r(2)=0.10, P<0.05). Conclusion. Plasma GDF-15 levels, CAIMT and conventional echocardiographic parameters in obese subjects with PCOS (25-35 yrs old) were comparable to those in either subjects with idiopathic hirsutism or healthy controls with similar anthropometric and metabolic profiles, suggesting that PCOS alone could not impart an early and higher risk independent of associated risk factors. GDF-15 might provide a link between future diabetes and cardiovascular risk in PCOS women.Item Knowledge, Attitudes and Behaviors of Physicians Towards Thyroid Disorders and Iodine Requirements in Pregnancy(2015) Kut, A.; Kalli, H.; Anil, C.; Mousa, U.; Gursoy, A.; 0000-0003-0776-8349; 0000-0002-8078-9376; 0000-0003-3802-9733; 25833359; A-2550-2015; I-1735-2018Purpose Thyroid disorders including iodine deficiency during pregnancy are important health problems worldwide. However, considering real life, assessment of knowledge, attitudes, and practice of physicians is lacking. We aim to evaluate knowledge, attitudes and behaviors of physicians towards thyroid disorders and requirements of iodine during pregnancy on a nationwide basis. Methods Clinicians from different medical disciplines most likely to encounter pregnant women in daily practice (i.e., obstetricians, endocrinologists, and family physicians) were included. Family physicians were selected from primary care centers; endocrinologists and gynecologists were selected from state hospitals. Randomly selected 322 physicians from seven geographical regions of Turkey were included. Subjects filled a questionnaire which consisted of three sections about knowledge, attitudes and behaviors towards thyroid disorders and iodine requirements during pregnancy. Results Physicians had insufficient and/ or erroneous knowledge about thyroid disorders during pregnancy. 73.1 % of endocrinologists, 32.7 % of family physicians, and 17.8 % of obstetricians knew the correct level of TSH during pregnancy (p < 0.001). 67.1 % of physicians thought it is unnecessary to offer iodine supplementation to pregnant women. Endocrinologists achieved the highest scores in each section, and also had the highest total scores (p < 0.001). Family physicians achieved higher scores than obstetricians. Conclusions Physicians who encounter pregnant women in Turkey do not have sufficient information about management of thyroid disorders and providing iodine support during pregnancy and lactation.Item Pregnancy and Sickle Cell Disease: A Review of the Current Literature(2016) Boga, Can; Ozdogu, Hakan; https://orcid.org/0000-0002-8902-1283; 26672916; AAD-6222-2021; AAD-5542-2021Sickle cell disease (SCD) is the most common hereditary disease worldwide, presenting with anemia and intermittent severe pain. Pregnancy in a patient with SCD is associated with high levels of maternal and fetal morbidity and mortality; the maternal and fetal death rates during pregnancy can attain 11.4% and 20%, respectively. Patient care has improved over time. However, certain management issues remain unresolved; these include the optimum policy in terms of prophylactic blood transfusion, and the use of antiplatelet drugs. Such issues are attributable to the heterogeneous nature of clinical SCD features, and the limitations of uncontrolled and prospective trials. In this review, we seek to facilitate a better understanding of relevant issues via creation of a comparative data profile extracted from current studies. This report may also encourage the drafting of standard operating procedure for management of pregnancy in SCD patients. (C) 2015 Elsevier Ireland Ltd. All rights reserved.Item Comparison between the use of vitamin d supplement by 20-49 year old women and their nutrition and depression status(2021) Soykurt, Seniha Cukurovali; Tayfur, Muhittin; Celen, Emine UlucamObjective: Aim of this study is to determine the possible relation between the nutritional status, food choices, eating habits, and Vitamin D supplement use of pregnant women between 20-49 years of age, and depression. Methods: The study was conducted between December 2018 and January 2019, on a total of 150 pregnant women between the ages of 20 and 49, who were admitted to Ankara Ataturk Training and Research Hospital Obstetrics and Gynaecology Policlinic. A questionnaire was used in order to identify personal data of the individuals, levels of serum Vitamin D, depression status, physical changes and other information regarding the changes in food consumption. Dietary habits and food consumption records of the individuals were obtained through face-to-face interviews. Results: A total of 75 individuals participating in the study used Vitamin D, while the other 75 did not. Of the individuals participating in the study, beck depression score median of those who used Vitamin D was found as 9.00 (IQR =6), while it was 33.00 (IQR =13) for those who did not. When the scores were analyzed based on Vitamin D use, it was found that there were statistically significant differences. Conclusions: There is evidence from epidemiological studies that show that vitamin D deficiency or insufficiency is associated with depression. Therefore, it is appropriate to recommend taking vitamin D supplements to prevent or treat depression in risk groups. Larger studies are needed to examine this situation in detail.Item Treatment of reflux disease during pregnancy and lactation(2017) Dagli, Ulku; Kalkan, Ismail Hakki; 0000-0003-0664-0976; 29199169; S-4068-2018Gastroesophageal reflux disease (GERD) is frequently seen during pregnancy. In the medical treatment of pregnant women with GERD, alginic acid and sucralfate can be used. Calcium- and magnesium-based antacids can also be used, particularly for patients with preeclampsia. In particular, ranitidine -a histamine-2 receptor blocker-is preferred. In the case of non-responsiveness to the abovementioned treatments, proton pump inhibitors (PPIs), except omeprazole, can be given considering the benefit-harm ratio for the mother and fetus after the first trimester. In cases with GERD during the lactation period, drugs having minimum systemic absorption, such as sucralfate and alginic acid, are preferable but there is no data.