Fakülteler / Faculties

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    Evaluating Palliative Care Needs in Middle Eastern Countries
    (2015) Kav, Sultan; 0000-0003-0361-7498; 25302525; V-9745-2019
    Background: Cancer incidence in Middle Eastern countries, most categorized as low- and middle-income, is predicted to double in the next 10 years, greater than in any other part of the world. While progress has been made in cancer diagnosis/treatment, much remains to be done to improve palliative care for the majority of patients with cancer who present with advanced disease. Objective: To determine knowledge, beliefs, barriers, and resources regarding palliative care services in Middle Eastern countries and use findings to inform future educational and training activities. Design: Descriptive survey. Setting/Subjects: Fifteen Middle Eastern countries; convenience sample of 776 nurses (44.3%), physicians (38.3%) and psychosocial, academic, and other health care professionals (17.4%) employed in varied settings. Measurements: Palliative care needs assessment. Results: Improved pain management services are key facilitators. Top barriers include lack of designated palliative care beds/services, community awareness, staff training, access to hospice services, and personnel/time. The nonexistence of functioning home-based and hospice services leaves families/providers unable to honor patient wishes. Respondents were least satisfied with discussions around advance directives and wish to learn more about palliative care focusing on communication techniques. Populations requiring special consideration comprise: patients with ethnic diversity, language barriers, and low literacy; pediatric and young adults; and the elderly. Conclusions: The majority of Middle Eastern patients with cancer are treated in outlying regions; the community is pivotal and must be incorporated into future plans for developing palliative care services. Promoting palliative care education and certification for physicians and nurses is crucial; home-based and hospice services must be sustained.
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    FDG PET/CT Imaging in Prostate Adenocarcinoma Presenting as Isolated Brain Metastases of Unknown Origin
    (2015) Erhamamci, S.; Reyhan, M.; Alkan, O.; 0000-0001-8550-3368; 0000-0001-7526-3460; 25052407; AAJ-5242-2021; AAM-4169-2021
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    In Vitro Effects on Biofilm Viability and Antibacterial and Antiadherent Activities of Silymarin
    (2015) Evren, Ebru; Yurtcu, Erkan; 0000-0003-4930-8164; 25937395; AAA-2998-2021; JWP-3001-2024
    Limited treatment options in infectious diseases caused by resistant microorganisms created the need to search new approaches. Several herbal extracts are studied for their enormous therapeutic potential. Silymarin extract, from Silybum marianum (milk thistle), is an old and a new remedy for this goal. The purpose of this study is to evaluate the antibacterial and antiadherent effects of silymarin besides biofilm viability activity on standard bacterial strains. Minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), antiadherent/antibiofilm activity, and effects on biofilm viability of silymarin were evaluated against standard bacterial strains. MIC values were observed between 60 and > 241 mu g/mL (0.25-> 1 mmol/L). Gram-positive bacteria were inhibited at concentrations between 60 and 120 mu g/mL. Gram-negative bacteria were not inhibited by the silymarin concentrations included in this study. MBC values for Gram-positive bacteria were greater than 241 mu g/mL. Adherence/biofilm formations were decreased to 15 mu g/mL silymarin concentration when compared with silymarin-untreated group. Silymarin reduced the biofilm viabilities to 13 and 46 % at 1 and 0.5 mmol/L concentrations, respectively. We demonstrated that silymarin shows antibacterial and antiadherent/antibiofilm activity against certain standard bacterial strains which may be beneficial when used as a dietary supplement or a drug.
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    Responding to Veiga Et Al. 'Long Term Radiological Features of Radiation-Induced Lung Damage'
    (2018) Oymak, Ezgi; Yildirim, Berna Akkus; Guler, Ozan Cem; Onal, Cem; 0000-0001-6661-4185; 0000-0001-6908-3412; 0000-0002-2742-9021; 30021696; AGG-9214-2022; V-5717-2017; AAC-5654-2020; D-5195-2014
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    In reply to Shih YJ et.al. (doi: 10.1111/odi.14349)
    (2022) Topkan, Erkan; Somay, Efsun; Yilmaz, Busra; 0000-0001-8120-7123; 0000-0003-0633-5648; 36114821; AAG-2213-2021
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    The effect of helicobacter pylori eradication on atrophic gastritis and intestinal metaplasia : a retrospective single center research
    (2020) Suna, N.; Etik, D.; Ocal, S.; Gunduz, C.; Acikgoz, A.; Bildik, I; Gursoy, A.; Kasgoz, I; Tuleylioglu, H.; Boyacioglu, A.; 0000-0003-3719-9482; 0000-0002-4724-0728; 0000-0001-6234-7788; 33094583; ABH-4817-2020; AAJ-4707-2021; AAI-8822-2021
    Background and study aims : Gastric cancer (GC) is one of the major causes of cancer-related deaths worldwide. Helicobacter pylori (Hp) plays an important role in gastric carcinogenesis by inducing precancerous changes such as atrophic gastritis (AG) and intestinal metaplasia (IM). In our study, we aim to compare the grade of AG and IM before and after Hp eradication in patients who underwent esophagogastroduodenoscopy (EGD) in our center. Patients and methods : The data of 40.060 patients who underwent EGD for various reasons in our Endoscopy Unit between June 2011 and November 2017 were retrospectively evaluated. The grade of AG and IM before and after Hp eradication of patients meeting the study criteria were compared with each other. In addition, these findings were compared using OLGA and OLGIM staging systems. Results : A total of 175 patients, 89 (50.9%) women and 86 (49.1%) men, were included in the study. The mean age was 55 +/- 12 years. The mean time between two EGD examinations was 38 +/- 14 months. Significant improvement was observed in the grade of AG on corpus and antrum after Hp eradication (P=0.000, P=0.008). In the corpus and antrum, the grade of IM was regressed but this was not significant (P=0.80 and P=0.370 respectively). There was a decrease in OLGA stages after Hp eradication (P=0.000). There was also a reduction in the OLGIM stages, but this was not significant(P=0.341). Conclusion: Our study demonstrates that Hp eradication may reduce the risk of developing GC by providing an improvement in AG and IM which are precancerous changes in GC.