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Item Choroidal Thickness in Ocular Sarcoidosis during Quiescent Phase Using Enhanced Depth Imaging Optical Coherence Tomography(2014) Gungor, Sirel Gur; Akkoyun, Imren; Reyhan, Nihan Haberal; Yesilirmak, Nilufer; Yilmaz, Gursel; https://orcid.org/0000-0001-6178-8362; https://orcid.org/0000-0002-2860-7424; https://orcid.org/0000-0001-9852-9911; https://orcid.org/0000-0002-8632-2873; https://orcid.org/0000-0002-2589-7294; 24912003; AAD-5967-2021; AAK-7713-2021; AAK-4587-2021; AAD-7299-2020; AAK-6987-2021Purpose: To evaluate the choroidal thickness in patients with ocular sarcoidosis during quiescent phase using enhanced depth imaging optical coherence tomography (EDI-OCT) and comparing it with normal subjects. Method: Eighteen eyes of 9 patients with ocular sarcoidosis (8 women, 1 man, mean age: 59.12 +/- 18.49 years) were enrolled in this study. Their subfoveal choroidal thickness was measured using EDI-OCT in the quiescent phase of uveitis, and compared with the age-, sex-, and spherical equivalent-matched normal subjects (6 women, 3 men, mean age: 59.6 +/- 14.22 years). Results: The mean subfoveal choroidal thickness was 281.76 +/- 88.1 mm in patients with sarcoidosis and 342.32 +/- 71.02 mm in controls. Significant differences were found at points between nasal 1500 mm and temporal 1000 mm to the fovea between patients and control group (p = 0.002, at fovea). Conclusions: Patients with ocular sarcoidosis had thinner choroids in the quiescent phases when compared to normal subjects.Item Evaluation of Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography in Patients with Migraine: A Comparative Study(2015) Karalezli, Aylin; Celik, Guner; Koktekir, Bengu Ekinci; Kucukerdonmez, Cem; 25633615; GOE-6067-2022; HTO-3612-2023Purpose: To assess choroidal thickness in patients with migraine and compare them with healthy controls, using spectral-domain optical coherence tomography (OCT). Methods: In this prospective case-control study, choroidal thicknesses of 20 newly diagnosed migraine patients and 20 age-and sex-matched healthy subjects were measured using a high-speed, high-resolution frequency domain (FD) OCT device (lambda = 840 nm, 26.000 A-scans/s, 5 mu m axial resolution). All patients underwent a complete ophthalmic examination before the measurements. OCT measurements were taken at the same time of day (9: 00 AM), in order to minimize the effects of diurnal variation. Results: There was a statistically significant difference in median choroidal thickness between the migraine patients (277.00 [interquartile range (IQR) 85.75] mu m) and controls (301.00 [IQR 90.50] mu m) (p = 0.012). There were significant differences at all measurement points (p<0.05 for all). Conclusions: The decreased choroidal thickness of patients with migraine might be related to the vascular pathology of the disease. Further studies are needed to evaluate the etiopathologic relationship between choroidal thickness and migraine.Item Evaluation of Retrobulbar Blood Flow and Choroidal Thickness in Patients with Rheumatoid Arthritis(2018) Kal, Ali; Duman, Enes; Sezenoz, Almila Sariguel; Ulusoy, Mahmut Oguz; Kal, Oznur; https://orcid.org/0000-0001-7544-5790; https://orcid.org/0000-0002-7030-5454; https://orcid.org/0000-0002-7751-4961; 28730400; AAJ-4936-2021; AAJ-4860-2021; AAJ-7586-2021PurposeTo evaluate whether retrobulbar blood flow and choroidal thickness (CT) are affected in patients with rheumatoid arthritis (RA), and the relationship between these values.MethodsWe evaluated 40 eyes of 20 RA patients and 40 eyes of 20 healthy controls. The enhanced depth imaging optical coherence tomography, color Doppler imaging, was held. Statistical analysis was performed.ResultsPeak systolic velocity (PSV) of ophthalmic (OA) and central retinal artery (CRA) were significantly higher in RA. No significant difference was observed when end-diastolic velocity (EDV) of OA and CRA was compared between the groups. The resistivity index (RI) of OA and CRA was higher in RA. Perifoveal/subfoveal CT was lower in RA. Negative correlation was detected between the RI of OA and the perifoveal CT, and a positive correlation was detected between RI of CRA and CT.ConclusionsOcular hemodynamics is effected by RA and can exaggerate ocular complications of various vascular diseases such as diabetes mellitus, hypertension, retinal vascular occlusions.Item Influence of Glycosylated Hemoglobin on The Choroidal Thickness(2018) Sahinoglu-Keskek, Nedime; Altan-Yaycioglu, Rana; Canan, Handan; Coban-Karatas, Muge; https://orcid.org/0000-0001-8544-103X; https://orcid.org/0000-0002-9139-8848; https://orcid.org/0000-0002-5877-6536; https://orcid.org/0000-0002-5877-6536; 28766280; T-4258-2017; AAG-3306-2019; AAB-6394-2021; AAB-6394-2021PurposeThe aim of the study reported here was to assess the influence of serum HbA1c levels on foveal choroidal thickness in diabetic patients.MethodsA total of 122 eyes from 122 patients who had type 2 DM were studied in this prospective, cross-sectional study. Patients were divided into three groups: 43 patients (43 eyes) without diabetic retinopathy (NDR), 39 patients (39 eyes) with diabetic retinopathy and no macular edema (DR/ME-), 40 patients (40 eyes) with diabetic retinopathy and macular edema (DR/ME+). Central foveal thicknesses and subfoveal choroidal thicknesses were noted. Subfoveal choroidal thickness measurement was taken perpendicularly from the outer part of the retinal pigment epithelial layer to the line corresponding to the choroidal-scleral junction. Serum glycosylated hemoglobin (HbA1c) levels were evaluated.ResultsNo significant differences in age, gender, pseudophakia were observed between the groups. There was no significant difference in HbA1c value among the three diabetic groups. Mean foveal choroidal thickness was 270.0942.41 in NDR group, 243.18 +/- 30.21 in DR/ME- group and 250.90 +/- 40.06 in DR/ME+ group. Mean foveal choroidal thickness in NDR group was significantly different from DR/ME- group. There was no statistically significant difference between the other groups among foveal choroidal thicknesses. There was no correlation between HbA1c and foveal choroidal thickness. Multiple regression analyses of two diabetic retinopathy groups showed no significant correlation between foveal choroidal thickness and HbA1c and also no significant correlation between foveal choroidal thickness and duration of diabetes.Conclusions p id="Par4Serum HbA1c levels were not correlated with foveal choroidal thickness. Choroidal thickness is effected by several factors as axial length, age and systemic diseases.Item Effect of Fingolimod (FTY720) on Choroidal Thickness in Patients with Multiple Sclerosis(2017) Kal, Ali; Ulusoy, Mahmut Oguz; Horasanli, Bahriye; Cezairlioglu, Sefik; Kal, Oznur; 0000-0002-7751-4961; 0000-0001-7544-5790; 0000-0003-3142-1011; 28619430; AAJ-7586-2021; AAJ-4936-2021Objective: Using spectral domain optical coherence tomography (SD-OCT), to compare the choroidal thickness in a healthy population (group 1), with newly diagnosed multiple sclerosis (MS) patients (group 2), with MS patients who underwent beta-interferon monotherapy (group 3) and MS patients who underwent fingolimod therapy for 1 year (group 4) Methods: Twenty-five control subjects (25 eyes), 24 newly diagnosed (24 eyes) MS patients, 22 MS patients who underwent fingolimod monotherapy for 1 year (22 eyes), and 24 MS patients who underwent beta-interferon monotherapy for 1 year (24 eyes) were included in this study. The control group consisted of age- and gender matched healthy individuals. The choroidal thickness measurements were performed using a high-speed and high-resolution SD-OCT device. The choroidal thickness measurements were compared using a One Way Anova and Post-Hoc Tukey test. Results: Ninety-five eyes of 95 participants were included in this study. The mean age of the control group was 27.83 +/- 4.60, and it was 26.83 +/- 6.79, 27.87 +/- 6. 46 and 27.58 +/- 6.65 in the newly diagnosed MS group, fingolimod group and beta-interferon group, respectively. In fingolimod group N-1000, N-1500 and T-1500 was significantly lower than control group. (p = 0.026, p = 0.06 p = 0.13) Conclusion: Choroidal thickness values at N-1000, N-1500 and T-1500 levels in fingolimod group were found lower than in control but higher than in newly diagnosed MS group. This result can be explained with the therapeutic effect of the fingolimod on MS.Item Impact of Valsalva Maneuver on Central Choroid, Central Macula, and Disk Fiber Layer Thickness Among High Myopic and Hyperopic Patients(2017) Kurultay Ersan, Isil; Emre, Sinan; 0000-0001-5616-4256; 27445069; AAL-4632-2021; T-5643-2019Purpose: To evaluate the alterations in mean central choroidal, central macular, and disk retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) during Valsalva maneuver among patients with high refractive errors. Methods: A total of 60 high myopic (>=-6.0 D) and 50 high hyperopic (>= + 3.0 D) eyes of 58 patients aged 1965 years with visual acuity of 20/20 and without any ophthalmologic or systemic diseases were evaluated by OCT before and after the Valsalva maneuver. The choroidal thickness was measured with enhanced depth imaging OCT method. Central macular thickness, disk RNFL thickness, and axial length were also assessed. Results: Mean choroidal thickness increased significantly from 275.0 +/- 27.2 mu m at rest to 279.8 +/- 31.6 mu m after Valsalva maneuver in high myopic patients, and from 308.2 +/- 27.3 mu m to 313.6 +/- 28.5 mu m in high hyperopic patients (p<0.01 for each). A significant negative correlation of the choroidal thickness was noted with axial length (r = -0.509, p<0.01) and age (r = -0.224, p = 0.01) in the overall study population. Mean central macular thickness was 242.9 +/- 44.4 mu m and 254.0 +/- 22.8 mu m, while mean disk RNFL thickness was 81.6 +/- 12.4 mu m and 98.4 +/- 13.3 mu m in high myopic and hyperopic patients, respectively. Valsalva maneuver was not associated with significant change in central macular or disk RNFL thickness. Conclusions: Significant association of Valsalva maneuver with an increase in choroidal thickness was noted among patients with high degree of myopia and hyperopia. Our findings emphasize the likelihood of increase in choroidal volume due to venous distension to be responsible for the increase observed in choroidal thickness after Valsalva maneuver.Item Topiramate-Induced Changes in Anterior Chamber Angle and Choroidal Thickness(2016) Karalezli, Aylin; Koktekir, Bengu Ekinci; Celik, Guner; 26020486; GOE-6067-2022Purpose: To investigate the acute effects of topiramate on the anterior chamber angle (ACA) and choroidal thickness in patients with migraine. Methods: This prospective study included 15 eyes of 15 patients with migraine who have been scheduled to start topiramate therapy. All patients underwent complete ophthalmic examination including measurement of the ACA and choroidal thickness using a spectral domain optical coherence tomography device (Optovue Inc.) and refractive status evaluation with an autorefractokeratometer (KR-8100; Topcon) at the baseline and 1 week after starting therapy. The patients were asked to report any pain or discomfort in their eyes during therapy at the follow-up visit. Results: None of the patients experienced pain or discomfort in their eyes. The mean ACA significantly decreased at the first week of the therapy compared with the baseline levels (40.34 +/- 7.06 degrees and 36.89 +/- 6.87 degrees, respectively) (P=0.001). However, the mean choroidal thickness increased from 277.33 +/- 95.60 mu m at the baseline to 323.40 +/- 84.50 mu m at the first week (P=0.01). There was a nonsignificant increase in the mean refractive error (from -0.25 +/- 0.54 diopter [D] at the baseline to -0.38 +/- 0.49 D after 1 week) (P=0.06). Conclusions: Topiramate can acutely decrease the ACA and increase the choroidal thickness. Because these effects may be asymptomatic, patients with migraine who start this therapy should be warned to be closely followed up by an ophthalmologist.Item Evaluation of choroidal thickness in children with acute asthma attack by optical coherence tomography(2021) Kurultay, Isil; Sancakli, Ozlem; 34482738Objective: To evaluate the change in central choroidal thickness in children with asthma attack before and after treatment with beta(2) agonists. Materials and methods: About 100 eyes of 50 patients (5-17 years old) with visual acuity of 20/20 who had no retinal, choroidal, and systemic comorbidity were examined by enhanced depth optical coherence tomography (EDI-OCT) before and after asthma attack treatment. Sixty eyes of 30 healthy children of similar age and gender were evaluated as the control group. The central choroidal thickness, peak expiratory flow (PEF), forced expiratory volume 1(FEV1), oxygen saturation, and heart rate were evaluated. Results: The mean age of the patients was 9.2 +/- 3.1 years, and the mean saturation values of patients was 97.2 +/- 1.3 before treatment, and it increased to 98.3 +/- 0.9 after treatment with a statistically significant difference. The mean FEV1 values were 80.8 +/- 15.2 before, and 92.7 +/- 12.9 after the treatment and PEF values were 75.9 +/- 18.6 before and 89.3 +/- 18.9 after treatment. This differences were statistically significant (p < 0.001). The average choroidal thickness before the treatment were 310.4 +/- 34.2 mu m and decreased to 302.7 +/- 34.4 mu m after the treatment, this decrease was statistically significant (p < 0.001). The mean choroidal thickness of the control group was 303.0 +/- 7.3 mu m and compared to the pre-treatment and post-treatment values, it was more similar to the post-treatment values, although there was no statistically difference. Conclusion: In our study, it was shown that choroidal thickness was significantly reduced in children with asthma who received attack treatment with beta(2) agonists, and it was similar to the control group after the treatment.Item Spectral domain optical coherence tomography findings of patients with ankylosing spondylitis(2020) Kal, Ali; Ulusoy, Mahmut Oguz; Orturk, Caner; 0000-0001-7544-5790; 32533454; AAJ-4936-2021Purpose The aim of this study is to evaluate the possible effects of (ankylosing spondylitis) AS on choroidal thickness (CT) and other retinal layers using spectral domain optical coherence tomography (SD-OCT). Methods This cross-sectional study group comprised 41 AS patients and age and sex-matched 46 control subjects. None of our patients had active anterior uveitis during the measurements. We evaluated and compared CT, retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC) thickness, focal loss volume (FLV) and global loss volume (GLV) of the participants. Results The CT of the patients at 1500 mu m (286.20 mu m +/- 65.81), 1000 mu m (309.55 mu m +/- 85.33) nasally to the fovea and subfoveal layer (339.93 mu m +/- 69.93) were thicker than in controls (p = 0.007,p = 0.037,p = 0.008). Except nasal layer, all RNFL layers were significantly thinner than controls (p < 0.001). GCC and macular thickness were also thinner than controls (p < 0.001). Conclusion In conclusion, present findings may suggest that the AS disease may affect the choroidal, RNFL and GCC thickness by disease's own inflammatory effect, independently from the uveitis history.Item Spectral domain optical coherence tomography findings in Turkish sickle-cell disease and beta thalassemia major patients(2019) Ulusoy, Mahmut Oguz; Turk, Hakan; Kivanc, Sertac Argun; 31528761Purpose: To assess probable structural changes using spectral domain optical coherence tomography (SD-OCT) on sickle-cell disease (SCD) and beta thalassemia major (B-TM) patients, without any retinal abnormalities. Methods: This cross-sectional study included 32 B-TM, 34 SCD patients, and 44 healthy controls. One of the eyes of all participants was evaluated for SD-OCT and choroidal thickness, retinal nerve fiber layer (RNFL) thickness, central macular thickness (CMT), ganglion cell complex (GCC). Results: Age, gender, and intraocular pressure (IOP) were not statistically different between the three groups. Hemoglobin (Hgb), hematocrite (Htc), and ferritin levels were not statistically different between the SCD and B-TM groups. Choroidal thickness at the subfoveal region was statistically higher in the control group (353.79 +/- 71.93) than in the B-TM (317.41 +/- 53.44) and SCD (283.21 +/- 63.27) groups. In addition, it was statistically higher in the B-TM group than the SCD group (P = 0.05). CMT did not differ among the three groups, average RNFL was only significantly thinner in SCD than in controls, and GCC thickness was significantly thinner in SCD than in controls and B-TM. Conclusion: In both diseases, we can show early structural changes even if proliferative or non-proliferative retinopathy or other ocular manifestations were not developed yet. Copyright (C) 2019, Iranian Society of Ophthalmology. Production and hosting by Elsevier B.V.