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search.filters.applied.f.publicationcategory: search.filters.publicationcategory.Makale - Ulusal Hakemli DergiSubject: search.filters.subject.Risk factors

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    The Ways to How Patients with Chronic Hepatitis C Find Out Their Disease and Risk Factors
    (2019) Turan Ozden, Hale
    Introduction: Transmission routes and seroprevalence of hepatitis C virus (HCV) may vary between countries and geographic regions. In this study, we planned to investigate patients with chronic hepatitis C admitted to our hospital in order to identify associated risk factors of HCV transmission in our region. Materials and Methods: Eighty-two patients who were admitted to the Infectious Diseases and Clinical Microbiology Outpatient Clink of our hospital between January 2011-December 2014 and who were diagnosed with chronic hepatitis C and/or liver cirrhosis were included into the study. Results: Forty-six (56.1%) of the patients were female and 36 (43.9%) were male patients. Mean age was 60.8 +/- 10.0 (26-81) year. Most common risk factors were surgical intervention (58.5%) and dental treatment (31.7%). Vast majority of the patients found out about their illnesses during routine examinations (81.7%). Conclusion: Early detection of the HCV infection is important in the follow-up and treatment of the disease. This study also emphasized the importance of routine screening in the detection of anti-HCV positivity.
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    Early Life Markers to Predict the Risk for Frequent Wheezing in Infants; Going on a Mysterious Road with an Old Friend, "The Eosinophil"
    (2018) Turhan, Ali Haydar; Arikoglu, Tugba; Tezol, Ozlem; Aslan, Gonul; Kuyucu, Semanur
    Objective: In most cases of asthma, wheezing symptoms start in early childhood. Although there are studies evaluating the factors that play a role in the development of childhood asthma, the predictive markers for frequent wheezing in early childhood are still unclear. The aim of our study was to investigate the relation between the wheezing episodes and the familial, prenatal, and postnatal risk factors, and the sensitivity of serum eosinophilic cationic protein (ECP) and eosinophil levels for predicting frequent wheezing. Materials and Methods: Fifty-seven children with acute wheezing and fifty healthy children aged between 1-36 months were included in the study. The children who had >= 3 episodes of wheezing in the next year after presentation were classified as the frequent wheezing group and those with fewer episodes were classified as the infrequent wheezing group. Administration of a comprehensive questionnaire about risk factors for wheezing; blood sampling for serum total IgE, ECP, eosinophil count, food and inhaled specific IgE levels and RSV/adenovirus serology; and skin prick tests were performed. Oral provocation tests were applied in cases of suspected food allergy. Results: Male gender (p=0.024), low socioeconomic level (p=0.046), initiation of milk formula (p=0.009) and eggs (p=0.018) before the fourth month, the presence of mold / umidity at home (p=0.023), eczema (p<0.001), and atopy (p=0.017) rates were significantly higher in the frequent wheezing group. The children with serum ECP levels >= 7.9 mu g/L at enrollment had higher risk of frequent wheezing than those with serum ECP 7.9 mu g/L (p=0.008). The sensitivity of ECP >= 7.9 mu g/L for frequent wheezing was 75.9% and the specificity was 68.7%. Similarly, serum total IgE (>= 154 IU/ml) and total eosinophil count (>= 390 /mm3) were found to be significantly higher in infants in the frequent wheezing group than the other groups (p=0.049, p=0.019). The multivariate analysis showed that the risk of frequent wheezing was 6.6 fold higher in children with a serum ECP level >= 7.9 mu g /L and 5.3 fold higher in the presence of RSV / adenovirus infection (p=0.026, p=0.038, respectively). Conclusion: In conclusion, our study suggested that the increase in serum ECP levels and the presence of RSV / denovirus infection significantly increased the risk of frequent wheezing in children with acute wheezing attacks.