Fakülteler / Faculties
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Item Evaluating the Aspects of Quality of Life in Individuals with Substance Use Disorder: A Systematic Review Based on the WHOQOL Questionnaire(2023) Bratu, Melania Lavinia; Sandesc, Dorel; Anghel, Teodora; Tudor, Raluca; Shaaban, Luai; Ali, Ayesha; Toma, Ana-Olivia; Bratosin, Felix; Turcu, Izabela; Gantsa, Andrei; Fericean, Roxana Manuela; Bondrescu, Mariana; Barata, Paula Irina; 38164463Substance Use Disorder (SUD) has become a significant public health concern and it profoundly impacts an individual's quality of life (QOL). This systematic review aimed to assess the QOL among patients with SUD, and to understand the differential impact of SUD on physical, mental, social, and environmental QOL domains, considering a variety of substances and identifying key factors that influence these outcomes. A comprehensive search was conducted in PubMed, Web of Science, Cochrane, and Scopus in January 2023, covering literature published until December 2022. The QOL was assessed using the World Health Organization Quality of Life (WHOQOL) instrument and the brief version of the WHOQOL, identifying the same four domains of QOL (physical, mental, social, and environmental). A total of 19 studies were selected for inclusion in the systematic review, based on individuals' polysubstance use, and excluding those using only nicotine or alcohol. The analysis included 6079 patients, with only 40.3% women, and a mean age of 36.6 years. The substances most commonly involved in SUD were cocaine (47.1%), alcohol (46.3%), and amphetamine (43.6%), considering most individuals being polysubstance users. The highest variability in QOL scores was observed in the physical domain. Mental disorders were reported in 68.3% of the patients, while long-term use of drugs, criminal history, unemployment, and low levels of education were identified as significant predictors for lower QOL by some of the studies. Similarly, sleep problems and teeth decay were also identified as significant worsening factors for QOL. This systematic review highlights that the WHOQOL survey is widely accepted and applicable for individuals with SUD worldwide. The results suggest a substantial negative impact of SUD on the QOL of affected individuals. The findings underscore the need for comprehensive interventions to address the physical, psychological, social, and environmental dimensions of QOL among individuals with SUD.Item Validity and Reliability of Turkish Transcultural Adaptation of the Prosthetic Limb Users Survey of Mobility(2023) Yosmaoglu, Sevgin; Yazicioglu, Gul; Demir, Yasin; Aydemir, Koray; Yosmaoglu, Hayri Baran; 0000-0001-7356-8500; 36037291; IVH-4699-2023Background: Amputee-specific, self-assessment mobility scales are essential to evaluate mobility in lower-limb amputees.Objectives: To evaluate the validity and reliability of a Turkish translation and adaptation of the Prosthetic Limb Users Survey of Mobility. Study design: This is a validation study. Methods: Turkish translation of the Prosthetic Limb Users Survey of Mobility (PLUS-M-T) from its original was performed following the rules of intercultural adaptation and translation methods. The PLUS-M-T and its 12-item short form were applied to '100 induviduals with limb loss twice in 3-day intervals. The structural validity analysis was determined by calculating the correlation with the Amputee Mobility Scale, which is a valid, reliable scale for assessing the functional level in amputees. The Cronbach alpha coefficient was calculated to analyze the internal consistency. The interclass correlation coefficient (ICC) and Spearman correlation coefficient (r) were calculated, and the test-retest reliability was determined. Results: A positive, high correlation was found between the first application and its repetition of both PLUS-M-T (ICC = 0.85, r = 0.94, P < 0.001) and 12-item short form (ICC = 0.92, r = 0.93, P < 0.001). The internal consistency was high for both PLUS-M-T (Cronbach alpha = 0.94) and 12-item short form (Cronbach alpha = 0.91). A positive, high correlation was found between the scores obtained from the Amputee Mobility Scale and PLUS-M-T (r = 0.84, P < 0.001) and 12 question short form (r = 0.77, P < 0.001). Conclusion: Turkish translation of the PLUS-M questionnaire is a valid and reliable scale for assessing the mobility of individuals who have undergone lower-extremity amputation using a prosthesis.Item Quality of Life And Anxiety in Turkish Patients with Anorectal Malformation(2014) Sari, Burcu Akin; Demirogullari, Billur; Ozen, Onur; Iseri, Elvan; Kale, Nuri; Basaklar, Can; https://orcid.org/0000-0002-9730-7206; 2-s2.0-84894287822; S-3910-2019AimThe aim of this study was to investigate quality of life (QoL) and anxiety level in Turkish children with anorectal malformation as well as the anxiety level of their mothers and the support group effects on anxiety. MethodsA total of 87 children and their parents were included. They were grouped according to children's age: <8 years (group 1), 8-12 years (group 2) and >12 years (group 3). The anxiety of all mothers and of children in group 3 was assessed by Spielberger's State-Trait Anxiety Index-2. The QoL of children in groups 2 and 3 was evaluated with the Ped-QL 4.0 test by self-report and proxy report. The QoL results in groups 2 and 3 were compared with age-matched controls. ResultsMothers in groups 1 and 3 were more anxious than were those in group 2. Adolescents in group 3 had poorer QoL compared with controls by self- and proxy reports. A significant difference was observed in QoL between the children who did and those who did not soil. The anxiety level was significantly lower in parents who attended more than one meeting. ConclusionsHigh anxiety and poor QoL levels in adolescence may have been related to the growing importance of body image. The higher anxiety levels of mothers in group 1 could be explained by an encounter with a baby who was different from the imagined baby and the newness of illness. QoL may have been perceived as being worse than what it was for psychological reasons.Item Impact of Rheumatoid Arthritis in Turkey: A Questionnaire Study(2014) Yucel, E.; https://orcid.org/0000-0002-4860-9072; 24960289; F-8858-2011Objective Unmet needs of rheumatoid arthritis (RA) patients regarding physician/patient communication, treatment preferences and quality of life issues were investigated in a Turkish survey study. Methods The study was conducted with the contribution of 33 rheumatologists, and included 519 RA patients. The study population included patients who had been on biologic therapy for >6 months and were still receiving biologic therapy (BT group), and those who were biologic naive, but found eligible for biologic treatment (NBT group). Of the RA patients, 35.5% initially had a visit to an internal disease specialist, 25.5% to a physical therapy and rehabilitation specialist, and 12.2% to a rheumatology specialist for their RA complaints. The diagnosis of RA was made by a rheumatologist in 48.2% of patients. Results The majority of RA patients (86.3%) visit their doctor within 15-week intervals. Most of the physician-patient communication focused on disease symptoms (99.0%) and impact of the disease on quality of life (61.8%). The proportion of RA patients who perceived their health status as good/very good/excellent was higher in the BT group than in the NBT group (74.3% vs. 51.5%, p<0.001). However, of those RA patients in the NBT group, only 24.8% have been recommended to start a biologic treatment by their doctors. With respect to dose frequency options, once-monthly injections were preferred (80%) to a bi-weekly injection schedule (8%). Conclusion In conclusion, RA patients receiving biologic therapy reported higher rates of improved symptoms and better quality of life and seemed to be more satisfied with their treatment in our study.Item Evaluation of Restless Legs Syndrome in Fibromyalgia Syndrome: An Analysis of Quality of Sleep and Life(2014) Civelek, Gul Mete; Ciftkaya, Pinar Oztop; Karatas, Metin; 24867908; AAD-3858-2021BACKGROUND AND OBJECTIVE: The aim of this study is to find prevalence and severity of restless legs syndrome (RLS) in patients with fibromyalgia syndrome (FMS) and detect effect of FMS and RLS coexistance on quality of sleep and life. METHODS: In this study, presence and severity of RLS were detected in patients with FMS and Pitsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS) and Fibromyalgia Impact Questionnaire (FIQ) scores of all patients were measured. RESULTS: One hundred and fifteen female patients with median age 49 (39.0-57.0) [median (25-75% interquartile range)] were included in the study. In 42.6% of patients RLS coexisting with FMS was found. RLS was classified as moderate in 42.9% of patients and as severe in 49.0% of patients. In patients with FMS ans RLS sleep quality, daytime sleepiness and quality of life were more severely impaired (PSQI scores were 9.0 +/- 4.4 vs 7.8 +/- 4.3, p = 0.003; ESS scores were 5.0(3.0-7.5) vs 3.0(1.0-4.3), p = 0.036 and FIQ scores were 68.1 +/- 9.8 vs 59.4 +/- 16.9, p = 0.027) compared to patients with only FMS. Prevalence of RLS was found higher in FMS than normal population and quality of sleep and quality of life were worse in patients with RLS. CONCLUSIONS: Presence of RLS should be investigated in every patient with FMS and treatment plans should also cover RLS in case of coexistance with FMS. Prospective cohort studies are needed for better explanation of FMS and RLS coexistance.Item The Impact of Psychiatric Disorders with Cardiac Syndrome X on Quality of Life: 3 Months Prospective Study(2014) Altintas, Ebru; Yigit, Fatma; Taskintuna, Nilgun; https://orcid.org/0000-0003-2735-4805; https://orcid.org/0000-0003-1541-6167; 25419392; G-8832-2015; ABC-8170-2021The aim of the study is to investigate the impact of psychiatric disorders with cardiac syndrome X (CSX) on the patients' quality of life, as well as the efficacy of psychiatric support. Fifty-six CSX and fifty-three Coronary Heart Disease patients were included in the study after coronary angiography. Patients were evaluated right after the angiography and 3 months thereafter. The socio-demographic characteristics, comorbid disorders, Beck Anxiety (BAI), Depression (BDI) Inventory, and Health Related Quality of Life (SF-36) were compared between groups. The most common mental disorders was depression which account for 41%, the next were anxiety disorders (64%, n = 36) and somatoform (24%, n = 14). Initially, BAI, BDI in the CSX group were significantly higher when compared to the control group. There was significant difference in all subgroups of SF-36 at the end of the second evaluation versus the first evaluation in the CSX patients. The present study revealed that patients with CSX have higher prevalence of psychiatric comorbidities and lower quality of life. Psychiatric approaches are benefit for CSX patients to improvement their quality of life.Item Parental Perceptions Concerning the Effect of Center-Based Childcare on Quality of Life for Healthy 2-To 4-Year-Old Children(2015) Atay, Gulsum; Uneri, Ozden Sukran; Vatandas, Nilgun Salk; Taskintuna, Nilgun; 0000-0001-8710-1426; 26613218; B-9987-2009In this study, we investigated the effects of center-based childcare on the quality of life in healthy 2- to 4-year-old children. The study was conducted in the Baskent University School of Medicine Department of Pediatrics, and comprised 168 healthy 2- to 4-year-old children followed in the well-child outpatient clinic. After giving informed consent, the accompanying parent was asked to complete the parent proxy report of the Pediatric Quality of Life Inventory (TM) 4.0 and a sociodemographic information form. Among the children in the study group, 42.26% (n=71) were girls and 31.36 % (n=51) were attending childcare; 69% of the respondent parents were mothers (n=116). The mean total scale score of the study sample was 82.71 +/- 11.77. Total scale scores as well as psychosocial health, physical health, social functioning and emotional functioning subscale scores were significantly higher in children attending childcare. In particular, mothers whose children were attending center-based childcare perceived their children's quality of life as higher, regardless of their educational and employment status. Improving access to center-based childcare may help to improve the quality of life for young children in Turkey.Item Patient-Reported Outcomes with Cemiplimab Monotherapy for First-Line Treatment of Advanced Non-Small Cell Lung Cancer with PD-L1 Of >= 50%: The EMPOWER-Lung 1 Study(2023) Gumus, Mahmut; Chen, Chieh-, I; Ivanescu, Cristina; Kilickap, Saadettin; Bondarenko, Igor; Ozguroglu, Mustafa; Gogishvili, Miranda; Turk, Haci M.; Cicin, Irfan; Harnett, James; Mastey, Vera; Naumann, Ulrike; Reaney, Matthew; Konidaris, Gerasimos; Sasane, Medha; Brady, Keri J. S.; Li, Siyu; Gullo, Giuseppe; Rietschel, Petra; Sezer, Ahmet; 36308296Background In the EMPOWER-Lung 1 trial (, NCT03088540), cemiplimab conferred longer survival than platinum-doublet chemotherapy for advanced non-small cell lung cancer (NSCLC) with programmed cell death-ligand 1 (PD-L1) >= 50%. Patient-reported outcomes were evaluated among trial participants. Methods Adults with NSCLC and Eastern Cooperative Oncology Group performance status 0 to 1 were randomly assigned cemiplimab 350 mg every 3 weeks or platinum-doublet chemotherapy. At baseline and day 1 of each treatment cycle, patients were administered the European Organization for Research and Treatment of Cancer Quality of Life-Core 30 (QLQ-C30) and Lung Cancer Module (QLQ-LC13) questionnaires. Mixed-model repeated measures analysis estimated overall change from baseline for PD-L1 >= 50% and intention-to-treat populations. Kaplan-Meier analysis estimated time to definitive deterioration. Results In PD-L1 >= 50% patients (cemiplimab, n = 283; chemotherapy, n = 280), baseline QLQ-C30 and QLQ-LC13 scores showed moderate-to-high functioning and low symptom burden. Change from baseline favored cemiplimab on global health status/quality of life (GHS/QOL), functioning, and most symptom scales. Risk of definitive deterioration across functioning scales was reduced versus chemotherapy; hazard ratios were 0.48 (95% CI, 0.32-0.71) to 0.63 (95% CI, 0.41-0.96). Cemiplimab showed lower risk of definitive deterioration for disease-related (dyspnea, cough, pain in chest, pain in other body parts, fatigue) and treatment-related symptoms (peripheral neuropathy, alopecia, nausea/vomiting, appetite loss, constipation, diarrhea) (nominal p < .05). Results were similar in the intention-to-treat population. Conclusions Results support cemiplimab for first-line therapy of advanced NSCLC from the patient's perspective. Improved survival is accompanied by improvements versus platinum-doublet chemotherapy in GHS/QOL and functioning and reduction in symptom burden.Item Effect of Inspiratory Muscle Training in the Management of Patients With Asthma A Randomized Controlled Trial(2018) Duruturk, Neslihan; Acar, Manolya; Dogrul, Mustafa Ilgaz; 29652761; ACK-5152-2022; AAD-3908-2020Purpose: The aim of this study was to investigate the effects of inspiratory muscle training (IMT) on respiratory muscle strength, exercise capacity, dyspnea, fatigue, quality of life, and daily living activities of asthmatic patients. Methods: Thirty-eight asthmatic patients, between 18 and 65 years of age, were enrolled in the study and randomly divided into 2 groups; IMT (n = 20) or control (n = 18). Participants in the IMT group performed 30 breaths using a patient-specific threshold pressure device, twice daily for 6 wk at 50% maximal inspiratory pressure (MIP), in addition to "breathing training" during this period. Participants in the control group performed only the "breathing training" (sham or no threshold pressure device). Outcome measurements, performed before and after the intervention, included pulmonary function test, respiratory muscle strength, 6-min walk test, modified Medical Research Council dyspnea scale, St George's Respiratory Questionnaire, Fatigue Severity Scale, and London Chest Activity of Daily Living scale. Results: Among the outcomes in the study, changes to key variables including MIP (P < .01); MIP, percent predicted (P < .01); maximal expiratory pressure (MEP), percent predicted (P < .01); 6-min walk test walking distance (P = .001); modified Medical Research Council scale (P = < .001); Fatigue Severity Scale (P = .03); St George's Respiratory Questionnaire symptoms (P = .03); London Chest Activity of Daily Living domestic (P = .03); and London Chest Activity of Daily Living leisure (P = .01) were significantly different in favor of IMT versus control. Conclusion: These findings suggest that IMT may be an effective modality to enhance respiratory muscle strength, exercise capacity, quality of life, daily living activities, reduced perception of dyspnea, and fatigue in asthmatic patients.Item Effects of Early Life Factors on the Health and Quality of Life of Older Adults(2018) Yilmaz, Fikriye; Tekin, Rukiye N.; 0000-0002-4884-3803; 28745423; AAF-7789-2020; AAZ-4775-2020Background: Few studies on the effects of early life factors on the health and quality of life of adults have been conducted in Turkey. We aimed to investigate the effects of early life factors on the health and quality of life of older adults. Methods: We administered a questionnaire to 350 adults, aged 50-89years, living in Cankaya, Ankara. The questionnaire covered sociodemographic characteristics, early life characteristics, health status, and the World Health Organization Quality of Life-Ageing scale. Data were analyzed using chi(2) tests, independent samples t-tests, one-way anova, and binary logistic regression analysis. Results: The analyses showed that the most important risk factors for chronic disease were being >= 65years (odds ratio (OR)=2.34), having a chronic health problem before 18years of age (OR=2.48), experiencing prolonged hospitalization or bed rest before 18years of age (OR=2.65), and experiencing parental unconcern during early life (OR=2.13) (P<0.05). In addition, having a high school education or less includes people who have primary or secondary or high school diploma (OR=1.65), having lived in a village (OR=1.65), having a low family economic status (OR=2.40), and having experienced one negative event (OR=1.41) or two or more negative events (OR=1.39) during their early lives were identified as important risk factors for low quality of life (P<0.05). Conclusion: Early life factors are among the important determinants of the health and quality of life of older adults in Turkey.