Fakülteler / Faculties
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Item Determination of the Effect of the Elimination Diet Applied for Overweight and Obese People with Food Intolerance on Body Composition and Biochemical Parameters(2018) Gubur, SemaFood Intolerance, is a reaction against food, but not immunological manner, and may be confused with real food allergies. In this study, effects of special weight-loss diet together with an elimination diet on body composition and biochemical parameters of overweight and obese people who were diagnosed with food intolerance were investigated. The study group consists of 20 patients in total who were followed-up and treated in Yorktest Turkey Laboratory; who were diagnosed with food intolerance, and whose BMI was > 26kg/m(2). Bloodletting for these patients was executed with Lancet from their fingertips, and the blood drawn from these patients was assessed via enzyme-linked immunosorbent assay (ELISA) method, and food reactions of patients were determined for each food. Biochemical parameters of these patients are routine tests, which are necessary for food intolerance tests, and they are analyzed at Yorktest Turkey Laboratory for two times: before and after elimination diet plus special weight-loss diet. It has been determined that, the most common sensivity is obtained against yeast, egg yolk and white, cranberry, cow's milk, chicken, lentils and parsley. Anthropometric measurements and biochemical parameters before and after elimination diet plus special weight-loss diet applied to participants, were significantly improved in statistical manner. Due to positive changes in body composition and biochemical parameters obtained through application of special weight-loss diets together with elimination diet applied to fat and obese people, we think that this diet might be used for medical nutrition treatment of obesity as a treatment option.Item Evaluation of the Relationship between Childhood Traumas and Adulthood Obesity Development(2016) Mutlu, Hayrettin; Bilgic, Vedat; Erten, Sebahattin; Aras, Sukru; Tayfur, Muhittin; 27399037This study aimed to delineate the relationship between childhood traumas and adulthood obesity. A total of 314 individuals (157 obese and 157 nonobese) were recruited in the study. After obtaining anthropometric and sociodemographic variables, the Childhood Trauma Questionnaire (CTQ) was administered to the participants. Overall scores of CTQ were determined to be 42.6 +/- 10.5 (higher trauma) in obese group and 37.2 +/- 6.6 (lower trauma) in nonobese group (P<0.001). Frequency rates of childhood traumatic experience were found to be 68.8% for obese people and 38.8% for nonobese people. In conclusion, an increased risk for adulthood obesity development was significantly associated with childhood traumatic experience.Item Obesity and Oxidative Stress in Patients with Different Periodontal Status: A Case-Control Study(2017) Atabay, V. E.; Lutfioglu, M.; Avci, B.; Sakallioglu, E. E.; Aydogdu, A.; https://orcid.org/0000-0002-1738-371X; 26932579; ABA-1100-2020Background and ObjectiveObesity has become an important global health concern as obesity-associated adiposity is supposedly related to systemic immunologic and inflammatory alterations. The aim of this study was to evaluate the effects of obesity on periodontally healthy and diseased tissue according to the changes in malondialdehyde (MDA), protein carbonyl (PC) and total antioxidant capacity (TAOC) levels in gingival crevicular fluid as biomarkers of oxidative stress (OS). Material and MethodsThe study sample comprised systemically healthy normal-weight (n = 45) and obese (n = 48) adults. Obesity was diagnosed according to body mass index, waist circumference and waist/hip ratio. Periodontal status was evaluated according to plaque index, gingival index, bleeding on probing, probing depth and clinical attachment level. Participants were distributed among six groups according to obesity and periodontal status, as follows: normal weight+periodontally healthy (NH); normal weight+gingivitis (NG); normal weight+generalized chronic periodontitis (NCP); obese+periodontally healthy (OH); obese+gingivitis (OG); and obese+generalized chronic periodontitis (OCP). MDA, PC and TAOC levels were measured using ELISA. ResultsThe MDA and PC levels in gingival crevicular fluid varied among groups, as follows: NCP > NG > NH (p < 0.01) and OCP > OG > OH (p < 0.01). Conversely, the levels of TAOC in gingival crevicular fluid varied as follows: NCP < NG < NH (p < 0.01) and OCP < OG < OH (p < 0.01). Paired comparisons conducted according to periodontal status showed MDA and PC levels to be higher, and TAOC levels to be lower, in the OCP group than in the NCP group, in the OG group than in the NG group and in the OH group than in the NH group. However, only the differences between the OCP and NCP groups were significant (p < 0.01). In both obese and normal-weight individuals, clinical assessments showed significant, positive correlations with MDA and PC levels and negative correlations with TAOC levels (p < 0.01). ConclusionObesity may influence periodontal tissue destruction and disease severity by increasing the level of oxidative stress in the presence of periodontal disease.Item The Relation Between Meal Frequency and Obesity in Adults(2018) Muftuoglu, Selen; Ozdemir, Merve; Saka, Mendane; Ok, Mehtap Akcil; Koseler, Esra; Bayram, Sinem; Yesil, Esen; Kose, Beril; Turker, Perim; Ercan, Aydan; Aksoydan, Emine; Tayfur, Muhittin; Kiziltan, Gul; 0000-0003-1569-7747; AAF-4491-2021; AAX-4714-2021; AAG-6763-2020; AAZ-8170-2020Objective: To determine the relation between meal frequency and obesity in adults. Methods: A cross-sectional study was done among 1829 volunteer (520 men, 1309 women) selected through a multi-stage stratified random sampling method during 2015/2016. A standardized, confidential data collection sheet was used. It included socio-demographic factors, dietary behaviors, anthropometric measurements and energy-macro and micronutrient intakes. Results: The median meal frequency of women and men were 4 and 3, respectively. Approximately 57% of men and 61% of women have skipped meals and 76.8% of them were skipped their lunch. In addition, the individuals whose BMI were under and over 25 kg/m(2) (72.4%, 78.3%, respectively) often skipped lunch. The meal frequency positively correlated with waist to hip ratio in women (p<0.05). Additionally, there were positively significant correlations between meal frequency and saturated fatty acids, fiber, vitamin A, vitamin C, calcium and iron intake (p<0.05). Conclusion: This study indicated that increased meal frequency may have a beneficial effect on micronutrients intakes and some anthropometric measurements among adults.Item Is There A Secular Trend Regarding Puberty In Children With Down Syndrome?(2022) Erdogan, Furkan; Guven, Ayla; 36457553IntroductionThere are very few studies on the age of onset and end of puberty in children with Down syndrome (DS). Also, data regarding the course of puberty in these children compared to their healthy peers is limited. Moreover, there is limited information regarding the effects of factors such as obesity and hypothyroidism on the puberty process in children with DS. Our aim in our study is to determine whether the pubertal development of children with DS differs from their healthy peers and from previous studies conducted with DS children. MethodsThe medical records of DS children were examined retrospectively. The anthropometric measurements and the age of onset of pubertal stages, and menarche were recorded. The patients' age at puberty onset, the puberty processes, and age at menarche were compared with their healthy peers and previously published data on children with DS. ResultsOf the 140 Down syndrome patients followed in our clinic, 51 of whom with puberty constituted the study group. The mean age of onset of puberty was 10.3 +/- 1.0 years in our group (10.0 +/- 0.8 years for girls, 10.6 +/- 1.2 years for boys, respectively). Obesity occurred in 46% of pubertal girls with DS. The age of menarche in girls with DS was 11.8 +/- 0.7 years. The menarche age of girls with DS was significantly different from healthy girls. In the DS boys, only the Tanner V stage ages were different from the healthy children. True- precocious-puberty was detected in three children. ConclusionAlthough breast development begins later in females with DS than in their healthy peers; menarche is detected earlier than in their peers and a tendency towards obesity in the whole population. While the age of pubertal onset was similar to healthy children in male patients, our findings suggest that their puberty duration is longer.Item Etiology of Increased Referrals for Evaluation of Early Puberty in a Tertiary Care Center in Turkey: True Precocious Puberty, Obesity, or Parental Anxiety and Lack of Knowledge?(2021) Cemeroglu, Ayse Pinar; Kaval, Damlanur; Ozcan, Ozan; 0000-0002-1653-7932; 0000-0002-9421-0855; 0000-0002-3430-5203; 33889682There has been a global increase in pediatric endocrinology referrals for the concerns of early puberty. The objective of this study was to determine the reasons behind this increase. A retrospective cross-sectional study was designed to analyze the clinical characteristics of patients seen for the concerns of early puberty in pediatric endocrinology clinic of a tertiary care center (Study A). Additionally, a prospective questionnaire study was designed to assess the knowledge and concerns of the mothers regarding the timing of puberty in girls (Study B). In study A, of the 305 girls, 42.9% were overweight/obese, 68.5% either had normal pubertal development for age or were prepubertal, 1 had non-classic congenital adrenal hyperplasia, and 2 had central precocious puberty. Of the 36 boys, 56% were overweight/obese, 64% either had normal pubertal development for age or were prepubertal, and 1 had non-classic congenital adrenal hyperplasia. In study B, 95% of the participants thought the girls have been developing earlier, over 10% considered the first sign of puberty to be normal after the age 14 years and 12.4% considered menarche to be normal after age 14 years. The common sources of anxiety for the participants regarding the earlier timing of puberty were psychosocial issues and short final height. In conclusion, many parents had wrong beliefs/information about the normal timing of puberty and were concerned about precocious puberty in girls. Education of parents about the normal timing of puberty may help avoiding unnecessary referrals, parental anxiety, and financial burden to the society.Item Is There a Relationship Between Insulin Resistance and Breast Cancer-Related Lymphedema? A Preliminary Study(2021) Doruk Analan, Pinar; Kaya, Emine; 33761281Background: High blood insulin levels, insulin resistance (IR), and obesity are components of metabolic syndrome (MetS). The literature has indicated a high risk of breast cancer in patients with MetS. However, no studies have been conducted evaluating the relationship between breast cancer-related lymphedema (BCRL), one of the most frequently encountered postbreast cancer treatment conditions, and IR. Therefore, the aim of this study was to evaluate whether there is a relationship between BCRL and IR. Methods and Results: A total of 28 patients diagnosed with breast carcinoma were included in this preliminary study. Patients were divided into BCRL (n = 15; mean age: 55.2 +/- 11.2 years) and non-BCRL (control) groups (n = 13; mean age: 55.17 +/- 6.57 years). Body mass index (BMI), waist and hip circumference, and fasting blood glucose and blood insulin levels of all patients were recorded. The Homeostasis Model Assessment (HOMA) test was used for the calculation of IR measurement with a value of 2.5 taken as an indicator of IR. Parameters were compared between groups. BMI, waist circumference measurements, blood insulin, and HOMA-IR levels were statistically significantly higher in the BCRL group than the control group (p < 0.05). HOMA-IR values >2.5 were found in 14 patients in the BCRL group. In the control group, only three patients had IR based on HOMA-IR criteria (p = 0.000). Hip circumference measurements and fasting blood glucose levels were similar between the groups (p > 0.05). Conclusions: BCRL appears to be associated with waist circumference, fasting blood insulin level, and HOMA-IR levels. In routine clinical practice, evaluation of IR may be important in the follow-up of this patient population.Item BMI, Physical Activity, Sleep Quality, Eating Attitudes, Emotions: Which One is Affected by Mindful Eating?(2021) Kose, Gizem; Tayfur, MuhittinPresent study, it was aimed to examine the eating attitude and mindful eating status of students and to examine the change of mindful eating status' besides informing with nutrition course. The study was executed by 318 healthy students aged 18-45 years, randomly selected among students studying at Uskudar University between September 2015 and May 2016. In addition to a survey form containing personal and health information of the students, the Eating Attitudes Test (EAT-40) was conducted by Savasir and Erol, and the Mindful Eating Questionnare-30 (MEQ-30) scale conducted by Turkish Kose et al. The mean age of the participants was 21.56 +/- 3.82 year. The mean score of the participants' EAT-40 score was found to be 24.22 +/- 13.98 and the mean score of the MEQwas 98.11 +/- 13.81. As the EAT-40 scores decreased, MEQ scores increased, but this relationship was not statistically significant (p> 0.05). It has been shown that 28.9% of students have an eating disorder risk. There was no statistically significant difference between men's (23.33 +/- 15.60) and women's (24.48 +/- 13.50) mean EAT-40 scores (p>0.05). Overweight-obese group was found to be having higher EAT-40 scores than the other BMI classes (p <0.05). While the students' body weight and BMI increased, the risk of eating disorder increased (r = 0.112, p <0.05 and r = 0.139, p <0.05), and mindful eating decreased (p> 0.05). A significant relationship was found between weight, BMI and MEQ subscales (r =-0.252, p <0.01 and r =-0.208, p<0.01). As food preferences evaluated, 33.3% of students that is vegan, 26.4% of the students that have no food preference and 24.1% of the students that don't eat red meat were at risk of eating disorder (p <0.05). There was no statistically significant difference between the EAT-40 score groups according to walking status of the participants (p> 0.05). There was a statistically significant relationship between walking status and emotional eating that is one of MEQ subscales (r = -0.159, p <0.01). As having nutrition course, EAT-40 score decreased and the score of MEQ increased (p> 0.05). There was no statistically significant relationship between the level of taking the course and EAT-40, MEQ or the subscales of MEQ (p> 0.05). In sum, nutrition courses influence students' eating attitudes and mindful eating positively. In addition, gaining mindfulness of eating will be helping manage to weight status.Item Evaluation of clinical, endocrine and metabolic findings in obese children with and without hepatosteatosis(2021) Basarir, Gunce; Ozcabi, Bahar; Sayman, Ozden Aksu; Akay, Hatice Ozturkmen; Yildiz, Feyza M.; 34142516Objectives: Non-alcoholic fatty liver disease (NAFLD) is a common obesity-related comorbidity in childhood. In this study, we aimed to evaluate predictors of NAFLD by comparing clinical, endocrine and metabolic findings in obese children with and without hepatosteatosis. Methods: Two hundred and eight obese children aged 6-18 years were included. The patients were divided into group 1 (patients with NAFLD, n=94) and group 2 (patients without NAFLD, n=114). Anthropometric measurements, pubertal stage, lipid profiles, fasting glucose and insulin, homeostatic model of assessment for insulin resistance (HOMA-IR), uric acid, total bilirubin, alanine aminotransferase (ALT), blood urea nitrogen, thyroid-stimulating hormone and free thyroxine parameters were compared retrospectively. Results: The mean body weight, body mass index (BMI), height, tri-ponderal mass index (TMI), insulin, HOMA-IR, triglyceride, ALT and uric acid values were significantly higher, while high-density lipoprotein-cholesterol (HDL-C) values were significantly lower in group 1. The 70.7% of obese children with hepatosteatosis and 83.9% of those without hepatosteatosis were correctly estimated by parameters including age, gender, ALT, HDL-C, fasting insulin and uric acid values. Conclusions: Since obesity-associated hepatosteatosis induces various long-term metabolic impacts in children, early detection is of critical importance. Age, gender, TMI, BMI, ALT, HDL-C, fasting insulin and uric acid values may help to predict the risk of hepatosteatosis. Besides, we assessed whether TMI compared to BMI does not have a better utility in estimating obesity-induced hepatosteatosis in children. This is the first study to show the association between TMI and hepatosteatosis in children.Item Outcome of Gastric Fundus and Pylorus Botulinum Toxin A Injection in Obese Patients Class I-II with Normal Pyloric Orifice Structure: A Retrospective Analysis(2021) Ferhatoglu, Murat Ferhat; Kartal, Abdulcabar; Filiz, Ali Ilker; Kebudi, AbutBackground: Any deterioration in pyloric muscle activity has the potential to influence gastric emptying. In such a case, gastric emptying time would also be changed due to the paralysis of pyloric muscles, which is the botulinum toxin's effect mechanism. This study aimed to investigate how the pyloric orifice structure influences the success of intragastric botulinum toxin type A injection (GBI) therapy in Class I-II obese patients for weight loss.Methods: The GBI applied patients were categorized according to pyloric orifice structure during upper gastrointestinal system endoscopy: Group A: the patients whose pylorus had normal peristaltic activity and closed completely and Group B: the patients whose pylorus did not close properly or were nonperistaltic. We measured the body mass index (BMI) of the patients before and 6 months after the procedure and expressed postprocedure weight loss in terms of the percentage of excess BMI (E-BMI%) loss. We compared preprocedure and sixth-month BMI and E-BMI% values. We applied the Student's t-test to analyze the differences among study groups, and p < 0.05 was accepted as statistically significant.Results: Seventy-seven patients completed the 6-month follow-up period. The measurements without considering the pyloric orifice structure showed that the mean BMI decrease in female patients (from 36.4 +/- 5.4 to 32 +/- 7.2 kg/m(2)) was significant (p < 0.05). And the BMI and E-BMI% loss in Group A were statistically significant (p < 0.05).Conclusion: We advise being selective and applying GBI to class I-II obese patients with normal pyloric orifice structure.