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search.filters.applied.f.language: search.filters.language.engSubject: search.filters.subject.early childhood

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    Hormonal Control During Infancy and Testicular Adrenal Rest Tumor Development in Males with Congenital Adrenal Hyperplasia: A Retrospective Multicenter Cohort Study
    (2023) Schroder, Mariska A. M.; Neacsu, Mihaela; Adriaansen, Bas P. H.; Sweep, Fred C. G. J.; Ahmed, S. Faisal; Ali, Salma R.; Bachega, Tania A. S. S.; Baronio, Federico; Birkebaek, Niels Holtum; de Bruin, Christiaan; Bonfig, Walter; Bryce, Jillian; Clemente, Maria; Cools, Martine; Elsedfy, Heba; Globa, Evgenia; Guran, Tulay; Guven, Ayla; Amr, Nermine Hussein; Janus, Dominika; Taube, Nina Lenherr; Markosyan, Renata; Miranda, Mirela; Poyrazoglu, Sukran; Rees, Aled; Salerno, Mariacarolina; Stancampiano, Marianna Rita; Vieites, Ana; de Vries, Liat; Abali, Zehra Yavas; Span, Paul N.; Claahsen-van der Grinten, Hedi L.; 0000-0002-2026-1326; 37837609; I-8448-2019
    Importance: Testicular adrenal rest tumors (TARTs), often found in male patients with congenital adrenal hyperplasia (CAH), are benign lesions causing testicular damage and infertility. We hypothesize that chronically elevated adrenocorticotropic hormone exposure during early life may promote TART development. Objective: This study aimed to examine the association between commencing adequate glucocorticoid treatment early after birth and TART development. Design and participants: This retrospective multicenter (n = 22) open cohort study collected longitudinal clinical and biochemical data of the first 4 years of life using the I-CAH registry and included 188 male patients (median age 13 years; interquartile range: 10-17) with 21-hydroxylase deficiency (n = 181) or 11-hydroxylase deficiency (n = 7). All patients underwent at least 1 testicular ultrasound. Results: TART was detected in 72 (38%) of the patients. Prevalence varied between centers. When adjusted for CAH phenotype, a delayed CAH diagnosis of >1 year, compared with a diagnosis within 1 month of life, was associated with a 2.6 times higher risk of TART diagnosis. TART onset was not predicted by biochemical disease control or bone age advancement in the first 4 years of life, but increased height standard deviation scores at the end of the 4-year study period were associated with a 27% higher risk of TART diagnosis. Conclusions: and relevance A delayed CAH diagnosis of >1 year vs CAH diagnosis within 1 month after birth was associated with a higher risk of TART development, which may be attributed to poor disease control in early life.
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    He Said, She Said, But What Do They Say?: Young Children's Perceptions of Father İnvolvement
    (2018) Unlu-Cetin, Senil; Olgan, Refika; https://orcid.org/0000-0001-9898-1609; AAA-5407-2020
    One of the important implications of the rights given to children by Article 12 of UN Convention on the Rights of Children 1989 is the inclusion of children in research on issues related to their lives. However, studies on father involvement are still conducted for young children not with them and there are no data-gathering techniques available that can be used specifically with young children. Within this context the main aim of this study is to develop new techniques to gather qualitative data from children aged between 50 and 72 months to understand how they perceive their fathers' involvement. Findings of the present study were consistent with the results of previous studies that depended on adult reports of father involvement. Both the findings and the techniques used with children in the present study have implications for future research into father involvement and its application.