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    Comparison of the Efficacy of Cabergoline and Bromocriptine in a Rat Model of Ovarian Hyperstimulation Syndrome
    (2018) Coban, Pinar Gulsen; Oruc, Ayla Sargin; Ozaksit, M. Gulnur; Demirtas, Aysegul; Helvacioglu, Fatma; Fidan, Pinar Ayran; Sirvan, Levent; Eroglu, Semra; https://orcid.org/0000-0002-6026-0045; AAH-8887-2021; AAD-8353-2020
    OBJECTIVE: To compare cabergoline and bromocriptine for their effectiveness in ovarian hyperstimulation syndrome (OHSS) and their impact on endometrial receptivity in a rat model. STUDY DESIGN: A total of 25 immature Wistar female rats were randomly assigned to 5 groups: group 1 (control), group 2 (hyperstimulated), group 3 (cabergoline), group 4 (2 mg/kg bromocriptine), and group 5 (4 mg/kg bromocriptine). Body-ovarian weights, the number of corpora lutea, and endometrial receptivity were investigated. RESULTS: Cabergoline appeared to be less effective in reduction in body weight (p = 0.042). Ovarian weight was significantly reduced by a higher dose of bromocriptine (p<0.000). The number of corpora lutea were similar. In the cabergoline group, endometrial pinopode expression was reduced. In the bromocriptine groups the presence of pinopode formation was not affected, whereas some of those displayed different structural features like dome or racket shaped of yet undetermined significance. CONCLUSION: According to our findings, bromocriptine, particularly in higher doses, might be preferred with regard to ovarian mass suppression, weight gain, and pinopode expression. Further studies assessing the efficacy and safety of different doses of bromocriptine administration in OHSS followed by clinical trials about implantation and pregnancy rates are required.
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    Role of prolidase activity and oxidative stress biomarkers in unexplained infertility
    (2021) Isbilen, Elif; Kulaksizoglu, Sevsen; Kirmizioglu, Mahmut; Komurcu, Ozge Karuserci; Tabur, Suzan; 34449881
    Objective Our aim was to explore the significance of serum prolidase enzyme activity and oxidative stress in women with unexplained infertility (UEI). Methods In this case-control study (n = 160; 86 cases; 74 controls) prolidase enzyme activity and total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), and vitamin E were measured in plasma using enzyme-linked immunosorbent assays. Results Prolidase enzyme activity and TAS levels were particularly higher in the patient group (P = 0.013, P = 0.001, respectively). Decreased OSI levels were detected in the patient group (P = 0.001). There was a positive relationship of prolidase with vitamin E in both patient and control groups (r = 0.892, P = 0.001, and r = 0.659, P = 0.001, respectively). A positive, but weak, relationship was identified between prolidase activity and TOS levels and also between vitamin E and TOS levels in the UEI group (r = 0.265, P = 0.049, and r = 0.288, P = 0.014, respectively). No association was found between prolidase and TOS levels or between vitamin E and TOS levels in the control group (r = 0.0097, P = 0.527, and r = 0.085, P = 0.610, respectively). Conclusion Our results showed an association between serum prolidase activity and oxidative stress in UEI patients. Further studies including greater groups are required to show the role of reactive oxygen species in UEI.