Fakülteler / Faculties
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Item Obsessive-Compulsive Disorder From Embodied Cognition Perspective(2022) Kocak, Orhan Murat; Kayipmaz, Selvi; Kutluturk Uney, Pelin; Haciyev, Ceyhun; https://orcid.org/0000-0002-7984-2440; AAK-3227-2021Obsessive Compulsive Disorder (OCD) is characterized by problems of control over behavior and cognition. Although almost all of the studies on pathogenesis of OCD point out fronto-striatal dysfunction, it is still not possible to reveal mechanisms to explain the entire clinical course of OCD through these circuits. A more holistic explanation can be given through the Embodied Cognition (EC) perspective, which suggests that the alteration/dysfunction of low-level sensory-motor process may appear as a multifarious extent of dysfunction of high-level cognitive processes. Fronto-striatal circuits play fundamental role in behavioral control. These circuits also have a central role for the feed-forward motor control (FFMC). In FFMC, the internal model of movement is driven by efference copies as templates for motor behavior, without being adjusted by sensory information. If impairment of low-level sensory-motor processing is crucial to occurrence of compulsions, one possible hypothesis about this impairment is the problem which emerges from occurrence of efference copy in FFMC. On the other hand, the efference copy has also pivotal role for subject's feeling of the agency of an action. Therefore, there may be role of failure in reproduction of the efference copy in the background of subjects' experience of losing control on compulsive behaviors. In this paper, we will discuss how the EC perspective which can be one of the biological bases of computationalism, which brings neuroscientific explanations on the functioning of nervous system to a more symbolic perspective, may contribute to our understanding of etiopathogenesis of OCD. In this perspective, our method will be to integrate the theoretical basis provided by EC perspective to the current models for OCD, rather than falsifying them.Item Commentary and Critique to "VTE Prophylaxis Therapy: Clinical Practice vs Clinical Guidelines" by Abukhalil et al(2022) Guven, Alper Tuna; Ozdede, Murat; https://orcid.org/0000-0002-6310-4240; 36276227Item Parameter Tuning Problem in Metaheuristics: A Self-Adaptive Local Search Algorithm for Combinatorial Problems(2020) Alabas-Uslu, Cigdem; Dengiz, BernaItem A Case of Common Variable Immunodeficiency with CREBP Gene Mutation without Rubinstein Taybi Syndrome Features(2022) Musabak, Ugur; Ceylaner, Serdar; Erdogan, Tuba; Ayva, Ebru Sebnem; 0000-0003-1511-7634; 35833092; AAU-1810-2020Hypogammaglobulinemias, based on inborn errors of immunity, are primary immunodeficiencies (PIDs) that can also be diagnosed for the first time in adulthood. Common variable immunodeficiency (CVID) is a multifactorial disease often symptomatic due to antibody deficiency. In addition, some PIDs are classified into the category of immunodeficiencies with syndromic features due to their accompanying clinical findings unrelated to immunity. In this article, a patient with CVID who was diagnosed in adulthood and who was revealed to have a mutation specific to Rubinstein-Taybi syndrome and clinical features reminiscent of this syndrome only after molecular tests was presented.Item A New Method for Surface-to-Air Video Detection and Tracking of Airborne Vehicles(2022) Pakfiliz, Ahmet Gungor; https://orcid.org/0000-0002-5901-228XDetection process of airborne targets may be thought simple because of the incompatible nature of aircraft, choppers, UAVs, and drones regarding clear sky background. When changes in the background are considered, brightness variation of the sky complicates the process. Changes in the shapes and types of clouds add another challenge to the process. Tracking process directly depends on the detection process and type of the data stream. The practical systems used for video detection and tracking of airborne targets are manual, and manual structures have some drawbacks compared to automatic structures. For video surveillance, guidance, regional security, and defense applications in dense environments, automatic detection and tracking process may be an obligation rather than preference. In this study, an automatic detection and tracking algorithm for video streams of airborne targets is proposed. A land-based moving camera captures the video data, and not only the flying objects but probably also the camera are in motion. Although the detection and tracking of moving objects via moving sensors is a relatively arduous task, this is the prevalent case in real-life scenarios. Video detection and tracking systems have one or more moving video sensors, while one or more flying air vehicles are in operation area. The proposed algorithm includes an image processing stage for detection and a tracking stage for initiation and continuation. An assessment study has been conducted for the actual video data and found that the proposed method yields successful results for detection, track formation, and continuation processes.Item Protective Effects Of Alpha-Lipoic Acid On Bleomycin-Induced Skin Fibrosis Through The Repression Of NADPH Oxidase 4 And TGF-Beta 1/Smad3 Signaling Pathways(2022) Kocak, Ayse; Ural, Cemre; Harmanci, Duygu; Oktan, Mehmet Asi; Afagh, Aysan; Sarioglu, Sulen; Yilmaz, Osman; Birlik, Merih; Akdogan, Gul Guner; Cavdar, Zahide; https://orcid.org/0000-0002-9322-5844; 35187969; ABD-1329-2021The aim of this study was to determine the protective effects of alpha-lipoic acid (ALA), which is known as a powerful antioxidant, and the possible related molecular mechanisms that mediate its favorable action on skin fibrosis in the bleomycin (BLM)-induced scleroderma (SSc) model in mice. The experimental design was established with four groups of eight mice: Control, ALA (100 mg/kg), BLM (5 mu g/kg), and BLM + ALA group. BLM was administered via subcutaneous (sc) once a day while ALA was injected intraperitoneally (ip) twice a week for 21 days. Histopathological and biochemical analyses showed that ALA significantly reduced BLM-induced dermal thickness, inflammation score, and mRNA expression of tumor necrosis factor-alpha (TNF-alpha) in the skin. Besides, the mRNA expressions of the subunits of NADPH oxidase, which are Nox4 and p22phox, were found to be significantly induced in the BLM group. However, ALA significantly reduced their mRNA expression, which were in parallel to its decreasing effect on serum total oxidant status (TOS) level. Moreover, it was found that ALA downregulated the mRNA expressions of alpha-smooth muscle actin (alpha-SMA), collagen type I and fibronectin in the skin tissue of the BLM group. Additionally, it was shown that ALA reduced significantly the TGF-beta 1 and p-Smad3 protein expressions in the BLM + ALA group. On the other hand, ALA did not exhibit any significant effect on the p38 mitogen-activated kinase (MAPK) activation induced by BLM. All these findings point out that ALA may be a promising treatment for the attenuation of skin fibrosis in SSc patients.Item Superscan Appearance of Ga-68 PSMA PET/CT in a Patient with Refractory Prostate Cancer(2022) Koc, Zehra Pinar; Ozcan, Pinar Pelin; Ercolak, Vehbi; Reyhan, Mehmet; https://orcid.org/0000-0001-8550-3368; 35114754; AAJ-5242-2021A 64-year-old male patient with metastatic prostate carcinoma diagnosis received lutetium-177 prostate-specific membrane antigen (PSMA) treatment; however, his disease progressed. Herein, presented the final images of the patient that demonstrated a superscan appearance in the Gallium-68 PSMA positron emission tomography/computed tomography, which is a rare phenomenon.Item National Multi-Center Observational Retrospective Study to Understand Treatment Patterns and Outcomes for Stage III Non-Small Cell Lung Cancer Patients in Turkey: Turkish Society for Radiation Oncology Study, STONE Trial(2022) Onal, Cem; Demiral, Ayse Nur; Atalar, Banu; Yalman, Deniz; Dagoglu, Nergiz; Hurmuz, Pervin; Erpolat, Petek; Akyurek, Serap; Gul, Sute Karabulut; Berber, Tanju; Guler, Ozan Cem; Umay, Cenk; Sert, Fatma; Karahacioglu, Eray; Birgi, Sumerya Duru; Yaprak, Gokhan; Saglam, Esra KaytanThis study investigated treatment patterns and outcomes in patients with inoperable stage III non-small cell lung cancer (NSCLC) treated with radiotherapy (RT) in Turkey. We included 492 patients with stage III NSCLC in this multi-center retrospective study. Pa-tient demographics, clinical characteristics, and clinical treatment patterns from the time of the initial diagnosis to disease progression were recorded. Additionally, the prognostic factors predicting overall survival (OS) and progression-free survival (PFS) were analyzed. For the initial treatment, 429 patients (89.2%) received chemotherapy and RT, whereas 53 patients (10.8%) were treated only with RT. The first disease progression occurred in 288 patients (58.4%) at 9.3 months (median) after the initial treatment, and 64.6% re-ceived treatment after first progression. The second disease progression occurred in 30 patients, and 20 patients (66.7%) received treatment. Median OS and PFS were 27.0 months and 13.4 months, respectively. Age (p< 0.001), stage (p= 0.04), poor performance score (PS) (p= 0.03) and RT doses (p= 0.002) were independent predictors for OS and PFS in our multivariate analysis. Additional significant predictors for OS in the multivariate analysis were gender (p= 0.004), treatment period (0.02), and irradiation technique (p= 0.02). Disease progression occurred in nearly 58% of the patients, and one-third of these patients remained untreated during the disease progression. These findings indicate a need for additional treatment options in patients with unresectable stage III NSCLC with high-risk features, namely older age, stage IIIB disease, poor PS, and lower RT doses.Item Hyponatremia in Acute Bronchiolitis(2021) Gultekingil, Ayse; https://orcid.org/0000-0001-7955-5735; 33409953; AAR-9945-2020Item Investigation of some machine learning algorithms in fish age classification(2021) Benzer, Semra; Garabaghi, Farid Hassanbaki; Benzer, Recep; Mehr, Homay Danaei; 0000-0002-5339-0554; A-5050-2014Marine and freshwater scientists use fish scales, vertebrae, otoliths and length-weights values to estimate fish age because reliable fish age estimation plays a very important role in fish stock management. The advances in technology and the widespread use of artificial intelligence have revealed the use of traditional observations and techniques in the fishing industry. The aim of this study was to evaluate the effectiveness of three disesteemed machine learning algorithms (NB, J48 DT, RF) in comparison with ANNs which has been widely used in such studies in the literature. In culmination, all three algorithms outperformed ANNs and can be considered as alternatives in case of coming across noisy and non-linear datasets. Moreover, among these three algorithms J48 DT and RF showed exceptional performance where the data for specific fish age groups weren't abundant.