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Author: search.filters.author.Ulusoy, Mahmut OguzSubject: search.filters.subject.Multiple sclerosis

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    Effect of Fingolimod (FTY720) on Choroidal Thickness in Patients with Multiple Sclerosis
    (2017) Kal, Ali; Ulusoy, Mahmut Oguz; Horasanli, Bahriye; Cezairlioglu, Sefik; Kal, Oznur; 0000-0002-7751-4961; 0000-0001-7544-5790; 0000-0003-3142-1011; 28619430; AAJ-7586-2021; AAJ-4936-2021
    Objective: Using spectral domain optical coherence tomography (SD-OCT), to compare the choroidal thickness in a healthy population (group 1), with newly diagnosed multiple sclerosis (MS) patients (group 2), with MS patients who underwent beta-interferon monotherapy (group 3) and MS patients who underwent fingolimod therapy for 1 year (group 4) Methods: Twenty-five control subjects (25 eyes), 24 newly diagnosed (24 eyes) MS patients, 22 MS patients who underwent fingolimod monotherapy for 1 year (22 eyes), and 24 MS patients who underwent beta-interferon monotherapy for 1 year (24 eyes) were included in this study. The control group consisted of age- and gender matched healthy individuals. The choroidal thickness measurements were performed using a high-speed and high-resolution SD-OCT device. The choroidal thickness measurements were compared using a One Way Anova and Post-Hoc Tukey test. Results: Ninety-five eyes of 95 participants were included in this study. The mean age of the control group was 27.83 +/- 4.60, and it was 26.83 +/- 6.79, 27.87 +/- 6. 46 and 27.58 +/- 6.65 in the newly diagnosed MS group, fingolimod group and beta-interferon group, respectively. In fingolimod group N-1000, N-1500 and T-1500 was significantly lower than control group. (p = 0.026, p = 0.06 p = 0.13) Conclusion: Choroidal thickness values at N-1000, N-1500 and T-1500 levels in fingolimod group were found lower than in control but higher than in newly diagnosed MS group. This result can be explained with the therapeutic effect of the fingolimod on MS.
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    Optical coherence tomography angiography findings of multiple sclerosis with or without optic neuritis
    (2020) Ulusoy, Mahmut Oguz; Horasanli, Bahriye; Isik-Ulusoy, Selen; 32048550
    Objective: Nowadays, retinal microvascular structures can be investigated using optical coherence tomography angiography (OCTA). We aimed to evaluate the probable vascular changes in the foveal and peripapillary regions of patients with multiple sclerosis (MS). Methods: A total of 20 patients with relapsing remitting multiple sclerosis (RRMS) and 24 healthy controls were recruited in this study. All participants' superficial and deeper retinal and peripapillary layers were evaluated using OCTA after a total ophthalmologic examination. Results: In the superficial plexus, the whole image (49.53 +/- 3.9% and 51.83 +/- 2.1%, p = 0.009), superior hemisphere (49.44 +/- 4.11% and 51.63 +/- 2.3%, p = 0.018), inferior hemisphere (49.75 +/- 3.9% and 52.03 +/- 2.2%, p = 0.012), parafoveal (51.87 +/- 3.9% and 53.08 +/- 3.46%, p = 0.048) and perifoveal (50.41 +/- 3.86% and 52.76 +/- 2.1%, p = 0.007) vascular densities were statistically significant lesser in patients with RRMS than in controls. In the optic disc OCTA parameters, the vessel density of the inferior (50.15 +/- 6.99% and 53.04 +/- 3.63% p = 0.043) and temporal sector (48.09 +/- 5.47% and 50.85 +/- 5.24%, p = 0.045) were statistically significantly lesser in patients with RRMS than in controls. Conclusion: The reductions in vessel density of the retinal or peripapillary area of patients with RRMS shown in this study should be investigated further to determine whether it is a secondary lesion to optic neuritis (ON) or a primary vasculopathic condition of MS.