Fakülteler / Faculties
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Item Comment on: Intensity Modulated Radiotherapy in Head and Neck Cancer: Initial Experience of the First Treated Cases from North-East India(2023) Topkan, Erkan; Somay, Efsun; Selek, Ugur; 0000-0001-8251-6913; 38187854; AAG-2213-2021; O-5474-2014Item In reply to Cheng et al. (DOI: 10.1186/s13550-023-00965-8)(2023) Somay, Efsun; Topkan, Erkan; Pehlivan, Berrin; Selek, Ugur; 0000-0001-8251-6913; 0000-0001-8120-7123; 37589948; AAG-2213-2021Item Letter to the Editor Regarding "Long-Term Swallow Outcomes and Factors Affecting Swallowing Dysfunction and Quality of Life Among Oral Cancer Patients: A Prospective Observational Study" by Thaduri Et Al. Eur Arch Otorhinolaryngol. 2023 Aug 7. Doi: 10.1007/S00405-023-08155-X(2023) Topkan, Erkan; Somay, Efsun; Selek, Ugur; 37594546; O-5474-2014; AAG-2213-2021Item Comment on: Quality of Life After Segmental Mandibulectomy and Free Flap for Mandibular Osteonecrosis: Systematic Review(2023) Topkan, Erkan; Somay, Efsun; 0000-0001-8251-6913; 37459741; AAG-2213-2021Item Systemic Inflammation Score for Predicting Radiation-Induced Trismus and Osteoradionecrosis of the Jaw Rates in Locally Advanced Nasopharyngeal Carcinoma Patients(2023) Somay, Efsun; Sezen, Duygu; Selek, Ugur; Besen, Ali Ayberk; Mertsoylu, Huseyin; Topkan, Erkan; 0000-0001-8120-7123; AAG-2213-2021We sought to determine the predictive value of the systemic inflammation score (SIS) for radiation-induced trismus (RIT) and osteora-dionecrosis of the jaw (ORNJ) in locally advanced nasopharyngeal carcinoma (LA-NPC) patients treated with concurrent chemoradio-therapy (C-CRT). LA-NPC patients (n= 188) who underwent C-CRT and pre-and post-C-CRT oral examinations from August 2010 to January 2022 were included. The three-tiered SIS groups were created using the serum albumin and lymphocyte-to-monocyte ratio (LMR) measures obtained on the first day of C-CRT: SIS-0: Albumin >= 40 g/dL and LMR >= 4.44); SIS-1: Albumin < 40 g/dL and LMR < 4.44 or albumin >= 0 g/dL and LMR >= 4.44; and SIS-2: Albumin < 40 g/dL and LMR <4.44. The primary objective was to ascertain whether there were irrefutable associations between pretreatment SIS groups and the respective post-C-CRT RIT and ORNJ rates. RIT and ORNJ were diagnosed in 33 (17.6%) and 21 (11.1%) patients, respectively. There were 12 (32.4%), 13 (12.7%), and 18 (45.0%) cases diagnosed with RIT in the respective SIS-0, SIS-1, and SIS-2 groups (p< 0.001). Similarly, there were 1 (2.7%), 11 (9.9%), and 9 (22.5%) cases with ORNJ diagnoses in the corresponding SIS groups (p< 0.001). The multivariate analysis's findings revealed that the SIS grouping was an independent predictor of RIT (p< 0.001) and ORNJ incidence rates (p< 0.001). Our study's findings indicate that the novel pretreatment SIS grouping is a dependable biomarker-based system, which can accurately predict the rates of RIT and ORNJ in LA-NPC patients who receive definitive C-CRT.Item In Reply to Bertl et al.(2023) Somay, Efsun; Topkan, Erkan; Selek, Ugur; 0000-0001-8087-3140; 0000-0001-8120-7123; 0000-0001-8251-6913; O-5474-2014; AAG-2213-2021Item Radiation Therapy for Ct1-2 Carcinoma of the Palatine Tonsil Diagnosed Via A Simple Tonsillectomy: Dosimetry and Patterns of Care in the IMRT Era(2023) Topkan, Erkan; Somay, Efsun; Yilmaz, Busra; 0000-0001-8120-7123; 37804565; AAG-2213-2021Item Response to Outcomes of Immediate Dental Implants in Vascularised Bone Flaps for Mandibular Reconstruction(2023) Somay, Efsun; Topkan, Erkan; 0000-0001-8120-7123; 0000-0001-8251-6913; 37565638; AAG-2213-2021Item Letter to the Editor Regarding "Radiologic Findings of Osteonecrosis, Osteoradionecrosis, Osteomyelitis and Jaw Metastatic Disease with Cone Beam CT"(2023) Yilmaz, Busra; Topkan, Erkan; 0000-0001-8120-7123; 37806191; AAG-2213-2021Item Pretreatment Masseter Muscle Volume Predicts Survival in Locally Advanced Nasopharyngeal Carcinoma Patients Treated with Concurrent Chemoradiotherapy(2023) Pehlivan, Umur Anil; Somay, Efsun; Yilmaz, Busra; Besen, Ali Ayberk; Mertsoylu, Huseyin; Selek, Ugur; Topkan, Erkan; 0000-0001-5871-0695; 0000-0001-8251-6913; 0000-0001-8120-7123; 37959329; AAG-2213-2021Background and purpose: Muscle loss is a significant indicator of cancer cachexia and is associated with a poor prognosis in cancer patients. Given the absence of comparable studies, the current retrospective study sought to examine the correlation between the total masseter muscle volume (TMMV) before treatment and the survival outcomes in locally advanced nasopharyngeal cancer (LA-NPC) patients who received definitive concurrent chemoradiotherapy (CCRT). Methods: A three-dimensional segmentation model was used to determine the TMMV for each patient by analyzing pre-CCRT magnetic resonance imaging. The optimal TMMV cutoff values were searched using receiver operating characteristic (ROC) curve analyses. The primary and secondary endpoints were the relationship between the pre-CCRT TMMV measures and overall survival (OS) and progression-free survival (PFS), respectively. Results: Ninety-seven patients were included in this study. ROC curve analyses revealed 38.0 cc as the optimal TMMV cutoff: <= 38.00 cc (n = 42) and >38.0 cc (n = 55). Comparisons between the two groups showed that the TMMV>38.0 cc group had significantly longer PFS [Not reached (NR) vs. 28; p < 0.01] and OS (NR vs. 71; p < 0.01) times, respectively. The results of the multivariate analysis demonstrated that the T-stage, N-stage, number of concurrent chemotherapy cycles, and TMMV were independent associates of PFS (p < 0.05 for each) and OS (p < 0.05 for each) outcomes, respectively. Conclusion: The findings of the current retrospective research suggest that pretreatment TMMV is a promising indicator for predicting survival outcomes in LA-NPC patients receiving definitive CCRT.