Fakülteler / Faculties

Permanent URI for this communityhttps://hdl.handle.net/11727/1395

Browse

Filters

2017 - 20192

Settings

Author: search.filters.author.Seymen, Cemile Mervesearch.filters.applied.f.language: search.filters.language.eng

Search Results

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Does Ginkgo biloba Protect Developing Testes from Chronic Hypobaric Hypoxia?
    (2017) Gul, Elif Ensari; Kaplanoglu, Gulnur Take; Helvacioglu, Fatma; Kaplanoglu, Iskender; Seymen, Cemile Merve; 0000-0002-6026-0045; 0000-0002-8945-3801; AAH-8887-2021; AAS-5415-2021
    OBJECTIVE: To evaluate the potential protective effects of Ginkgo biloba on developing testes exposed to chronic hypobaric hypoxia during their prenatal life. STUDY DESIGN: Twelve pregnant Wistar albino rats on the fifth gestational day were placed in hypoxic chambers for the upcoming 15 days. Six pregnant female rats were kept under normal atmospheric conditions during the pregnancy as a control group. The study groups were as follows: Control, Hypoxia, and Hypoxia + Ginkgo biloba. Ginkgo biloba was administered for each designated postnatal sacrifice day. For the Hypoxia + Ginkgo biloba group, after birth, 100 mg/kg of Ginkgo biloba extract was administrated orally to the newborn male rats. Testes tissues were sampled on postnatal days 7, 14, and 21 from each group, and PCNA, TUNEL, and TEM examinations were performed. RESULTS: PCNA immunoreactivity was decreased and TUNEL positive cell number was increased in the hypoxic group. TEM examination revealed degenerative changes in hypoxic group testes tissue. Hypoxia changed the cell cycle in spermatogenic series by reducing proliferation and increasing apoptosis. Spermatogenic cell degeneration and high Leydig cell activity were determined in the hypoxia group by TEM examinations. CONCLUSION: We believe that Ginkgo biloba has protective effects on testes tissue, especially in long-term use.
  • No Thumbnail Available
    Item
    Penetration Depth in Nanoparticles Incorporated Radiofrequency Hyperthermia into the Tissue: Comprehensive Study with Histology and Pathology Observations
    (2019) Nasseri, Behzad; Kocum, Ismail Cengiz; Seymen, Cemile Merve; Rebiee, Navid; 31432798
    In present study, the effective penetration of radiofrequency (RF) induced gold decorated iron oxide nanoparticles (GS@IONPs) hyperthermia was investigated. The effective penetration depth of RF also the damage potency of hyperthermia was evaluated during histopathology observations which were done on the chicken breast tissue and hepatocellular carcinoma (HCC) models. The thermal damages are well- documented in our previous cellular study which was engaged with potency of RF hyperthermia in Epithelial adenocarcinoma (MCF-7) and fibroblast (L-929) cells deaths [1]. In recent work, PEGylated iron oxide nanoparticles (IONPs) were used as base platform for gold magnetic nanoparticles (GS@IONPs) formation. The 144.00015 MHz, 180W RF generator was applied for stimulating the nanoparticles. The chicken breast tissue and the hepatocellular tumor model was considered in the experimental section. In histology studies, the structural changes also the effective penetration depth of RF induced nanoparticles was observed through microscopic monitoring of the tissue slices in histology observations (Gazi medical school). The highest damage level was seen in 8.0 mu m tissue slices where lower damages were seen in depth of 1.0 cm and more inside tissue. The histology observations clarified the effective penetration depth of RF waves and irreversible damages in the 2.0 cm inside the tissue.