Fakülteler / Faculties

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    Long-Term Results of Kidney Transplantation in Patients with Familial Mediterranean Fever
    (2023) Bitik, Berivan; Hatipoglu, Bugra; Sayin, Burak; Kanbur, Aysenur Yalcintas; Bursa, Nurbanu; Oygur, Cagdas Sahap; Ozdemir, Handan; Colak, Turan; Haberal, Mehmet; Yucel, Ahmet Eftal; 0000-0001-5803-915X; 0000-0002-7528-3557; 0000-0002-3462-7632; 0000-0002-0168-2993; 36544375; AAI-9195-2021; X-8540-2019; AAJ-8097-2021
    IntroductionLong-term kidney transplantation (KT) results in patients with familial Mediterranean fever (FMF)-related amyloidosis are not well studied. This study reviewed the long-term survival outcomes of FMF patients who underwent KT. MethodsWe compared the outcomes of 31 patients who underwent (KT) for biopsy-proven amyloidosis secondary to FMF with 31 control patients (five with diabetes mellitus and 26 with nondiabetic kidney disease) undergoing KT between 1994 and 2021 at Baskent University Hospital. All data were recorded retrospectively from patients' files. Results: The median age (quartile deviationQD) at the time of KT in the FMF and control group were 31 (6.7) and 33 (11), respectively. The median follow-up period (QD) after KT was 108 (57) months in the FMF and 132 (72) months in the control group. In the FMF group, graft and patient survivals were 71% and 84% at 5 years and 45% and 48% at 10 years, respectively. In the control group, graft and patient survivals were 79% and 100% at 5 years and 63% and 71% at 10 years, respectively. Patient survival in the FMF group at 5 years was significantly lower than in the control group (p = .045). There was no statistically significant difference between the FMF and control groups in terms of graft and patient survival, and serum creatinine levels at 10 years. All patients were given triple immunosuppressive treatment with cyclosporine, mycophenolate mofetil, and prednisolone. Three patients received anakinra and one received canakinumab in addition to colchicine treatment. One FMF patient also underwent heart transplantation due to AA amyloidosis. Of the FMF patients, 11 died during follow-up. ConclusionWe have found that the long-term outcome of KT in patients with FMF amyloidosis is numerically worse but not statistically different from the control group. However, short- and long-term complications still need to be resolved.
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    Interactive Effects of Acupuncture on Pain and Distress in Major Burns: An Experiment with Rats
    (2015) Abali, Ayse Ebru; Cabioglu, Tugrul; Ozdemir, Handan; Haberal, Mehmet; 0000-0002-1298-7944; 0000-0002-3462-7632; 0000-0002-7528-3557; 25433758; AAE-8704-2021; AAJ-8097-2021; X-8540-2019
    This study sought to investigate the interactive effects of acupuncture on pain and distress and the local progress in the burn wound in an experimental major burn model. Forty-eight male Sprague-Dawley rats were divided into six groups: S group (sham/observation during 7 days after injury); SA group (sham/acupuncture/observation during 7 days after injury); Si group (burns/observation during 1 h after injury); BA1 group (burns/acupuncture/observation during 1 h after injury); 57 group (burns/observation during 7 days after injury); and BA7 group (burns/acupuncture/observation during 7 days after injury). Pain and distress scores were evaluated throughout the study. The amounts of neutrophils and mononuclear cells were evaluated semiquantitatively, and the number of microvessels was evaluated quantitatively. Our data indicated that the average pain score of BA7 group was significantly lower than the other study groups. Histopathologic investigations indicate that the amounts of neutrophil and mononuclear cell and numbers of microvessels in the unburned skin were higher in acupuncture-applied groups. The number of microvessels in burn wounds of BA7 group was significantly higher than that of the other groups. Our data suggest that acupuncture provides low pain and distress scores in experimental rat model, and it contributes to wound healing with an enhanced angiogenesis during the acute phase of burns. Future clinical and experimental studies should be conducted to discern the benefits from acupuncture in pain management of burn patients. (C) 2014 Elsevier Ltd and ISBI. All rights reserved.
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    Eculizumab in the Treatment of Dense Deposit Disease
    (2015) Gulleroglu, Kaan; Avci, Begum; Kantar, Asli; Ozdemir, Handan; Baskin, Esra; 0000-0002-5375-379X; 0000-0003-1434-3824; 0000-0002-7528-3557; 0000-0003-1434-3824; 0000-0003-4361-8508; GYU-5220-2022; AAJ-8833-2021; X-8540-2019; F-3294-2013; B-5785-2018
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    Effects of Late Acute Rejection on Graft Survival and Outcome in Pediatric Renal Transplant Recipients
    (2015) Baskin, Esra; Kantar, Asli; Gulleroglu, Kaan; Ozmen, Esra; Ozdemir, Handan; Kirnap, Mahir; Moray, Gokhan; Haberal, Mehmet; 0000-0002-3462-7632; 0000-0002-7528-3557; 0000-0003-2498-7287; 0000-0003-1434-3824; 0000-0003-4361-8508; /0000-0003-1434-3824; AAJ-8097-2021; X-8540-2019; AAE-1041-2021; F-3294-2013; B-5785-2018; AAH-9198-2019; AAJ-8833-2021
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    Primary B-Cell Lymphoma of Liver And Spleen: Report of Two Cases
    (2015) Demir, Senay; Gezer, Hasan Ozkan; Yazici, Nalan; Ozdemir, Handan; Torun, Nese; Sarialioglu, Faik; 0000-0002-7528-3557; 0000-0002-8257-810X; 0000-0002-4209-9075; 0000-0002-5597-676X; X-8540-2019; AAL-7766-2021; AAK-9310-2021; AAE-2718-2021; AAM-5138-2021; J-3197-2013
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    Significance of Colonoscopic Findings in Patients After Kidney Graft
    (2015) Ensaroglu, Fatih; Harmanci, Ozgur; Ocal, Serkan; Korkmaz, Murat; Moray, Gokhan; Ozdemir, Handan; Colak, Turan; Selcuk, Haldun; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0003-3719-9482; 0000-0002-8445-6413; 0000-0002-8372-7840; 0000-0003-2498-7287; 0000-0002-9333-782X; 0000-0002-3462-7632; 0000-0002-0643-4980; 26640913; X-8540-2019; ABH-4817-2020; AAJ-6976-2021; AAJ-8554-2021; AAE-1041-2021; AAM-1330-2020; AAJ-8097-2021
    Objectives: We aimed to investigate the colonoscopy findings in patients after kidney transplant. Materials and Methods: We retrospectively analyzed kidney transplant patients who had colonoscopy examinations for various indications between 2011 and 2015. Results: Eighty-one patients (25 women and 56 men) with a mean age of 39 years (range, 18-64 y) were identified. Mean follow-up after transplant was 9 years (range, 1-29 y). The most common indications for colonoscopy were diarrhea (41%), anemia (29%), gastrointestinal bleeding (12%), abdominal pain (12%), and unexplained weight loss (6%). Either colitis or ileitis or both were diagnosed in 20 patients (25%), whereas polyps were found in 9 patients (11%). One patient presented with hematochezia, which was diagnosed as cytomegalovirus colitis. The remaining cases of colitis or ileitis were diagnosed as nonspecific inflammation. Indications for colonoscopy were not correlated with age, duration after transplant, or use of immunosuppressive drugs. A subgroup analysis for mycophenolate-induced colitis found that 88% of patients used mycophenolate, but presence of colitis or ileitis had no statistical correlation with its use. In patients with poor gastrointestinal symptoms, the only significant predictor of presence of colitis or ileitis was a high C-reactive protein value (> 5 mg/dL; P=.02). Conclusions: Incidence of colitis and/or ileitis is a relatively common finding in patients after kidney transplant. Opportunistic infections, mycophenolate use, and mild degree of indeterminate colitis or ileitis disease may be the underlying condition. Cytomegalovirus infection should be screened in all recipients because it may cause serious complications or death in chronically immuno-compromised patients.
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    Outcomes of Patients With Hepatocellular Carcinoma After Liver Transplant
    (2015) Moray, Gokhan; Kirnap, Mahir; Akdur, Aydincan; Soy, Ebru; Tezcaner, Tugan; Boyvat, Fatih; Ozdemir, Handan; Haberal, Mehmet; 0000-0002-0993-9917; 0000-0002-8726-3369; 0000-0002-3462-7632; 0000-0002-3641-8674; 0000-0003-2498-7287; 0000-0002-7528-3557; 26640906; AAC-5566-2019; AAA-3068-2021; AAJ-8097-2021; AAD-9865-2021; F-4230-2011; AAH-9198-2019; AAE-1041-2021; X-8540-2019
    Objectives: Liver transplant is one of the few effective treatments for hepatocellular carcinoma. Our aim in this study was to evaluate the risk factors for hepatocellular carcinoma recurrence after liver transplant. Materials and Methods: In this retrospective study, conducted between October 1988 and March 2015, four hundred seventy-three liver transplants were performed at our institution. Of these, 231 were pediatric and 242 were adult. Among these patients, liver transplant was performed in 58 patients (12.3%) for treatment of hepatocellular carcinoma. Results: Hepatocellular carcinoma recurrence was detected in 14 patients (24.1%). Overall 5-year and 10-year survival rates of patients underwent liver transplant beyond the Milan criteria for hepatocellular carcinoma were 50.3% and 43.1%. Overall, 5- and 10-year survival rates of patients underwent liver transplant within the Milan criteria for hepatocellular carcinoma were 78.4% and 72.6%. The main predictive variable was whether the tumor had expensed beyond the Milan criteria. Conclusions: As expected, outcomes were significantly better in the Milan criteria group. Although the overall- and disease-free survival rates were promising in such a group of patients who had no better chance, it could be asserted that liver transplant is a safe and effective treatment option with promising results, even if the tumor expanse is beyond the Milan criteria.
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    Liver Transplantation and Auxiliary Partial Orthotopic Transplantation Outcomes in Wilson's Disease: Results of a Single Center
    (2018) Soy, Ebru H. Ayvazoglu; Akdur, Aydincan; Moray, Gokhan; Boyacioglu, Sedat; Torgay, Adnan; Arslan, Gulnaz; Ozdemir, Handan; Haberal, Mehmet; https://orcid.org/0000-0002-0993-9917; https://orcid.org/0000-0002-8726-3369; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-9370-1126; https://orcid.org/0000-0002-6829-3300; https://orcid.org/0000-0002-7528-3557; https://orcid.org/0000-0002-3462-7632; AAC-5566-2019; AAA-3068-2021; AAE-1041-2021; AAE-7637-2021; AAJ-5221-2021; X-8540-2019; AAJ-8097-2021
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    Renal Cell Carcinoma in Transplanted Kidney
    (2016) Soy, Ebru H. Ayvazoglu; Kizilkan, Yalcin; Ozdemir, Handan; Yildirim, Sedat; Moray, Gokhan; Haberal, Mehmet; https://orcid.org/0000-0002-0993-9917; https://orcid.org/0000-0002-5735-4315; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-3462-7632; AAC-5566-2019; AAF-4610-2019; AAE-1041-2021; AAJ-8097-2021
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    Ultrastructural Findings and Capillary HLA-DR Expression in Renal Allografts with Humoral, Vascular and Tubulointerstitial Rejection: Correlation with Development of Transplant Glomerulopathy
    (2016) Ozdemir, Handan; Ozdemir, Nurhan; Haberal, Mehmet; https://orcid.org/0000-0002-5682-0943; https://orcid.org/0000-0002-3462-7632; AAK-1697-2021; AAJ-8097-2021