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Author: search.filters.author.Oz, IsilayHas files: Yes

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    Role of Single Nucleotide Polymorphisms of Mammaglobin-A Gene in Nasal Polyposis: A Case Control Study
    (2020) Oz, Isilay; Ozdas, Sibel; Bastimur, Sibel; Ozdas, Talih; Muz, Sami Engin; Atilla, Huntuk; Kurt, Kenan; Erbek, Selim; 0000-0003-4825-3499; 0000-0002-7380-4566; B-7604-2019; AAJ-1452-2021
    Objective: Nasal Polyposis (NP) is a chronic inflammatory disease and genetic factors play an important role in the pathophysiology. Mammaglobin-A (MGA) gene expression was significantly higher in patients with NP and chronic rhinosinusitis compared to normal mucosa. In the present study, we investigated the relationship between single nucleotide polymorphisms (SNPs) in the MGA gene and nasal polyposis in the Turkish population. Materials and Methods: A total of 87 patients diagnosed with NP and 60 healthy volunteers were enrolled in the study. Genotypes of MGA promoter SNPs c38C>G, c.21C>T, c55+186G>A and c.243+230A>T were determined by light SNP ASSAY after real time PCR analysis using genomic DNA samples obtained from the peripheral blood samples of all participants. Results: A total of 87 NP patients, 51 male and 36 female, with a mean age of 38.18 +/- 9.5 years were included in the study. No significant difference was determined at all positions c38C>G, c.21C>T, c55+186G>A and c.243+230A>T in nasal polyp patients compared to controls with and without allergic rhinitis (AR). Conclusion: MGA gene c38C>G, c.21C>T, c55 + 186G>A, and c.243 + 230A>T genotypes did not appear to be associated with susceptibility to NP with and without AR in our study population.
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    The Impact of Serum 25-Hydroxyvitamin D3 Levels on Allergic Rhinitis
    (2019) Coban, Kubra; Oz, Isilay; Topcu, Deniz Ilhan; Aydin, Erdinc; 0000-0002-1219-6368; 31569970; E-3717-2019
    We aimed to clarify the relation between allergic rhinitis and the serum levels of 25-hydroxivitamin D in the adult population. The study group consisted of 86 patients with allergic rhinitis who were diagnosed with the help of history of allergy, positive signs for allergy, blood samples, and positive skin prick tests; while the control group included 43 age- and sex-matched healthy volunteers with negative skin prick tests. The demographic data, medical history, findings in the physical examinations, serum levels of total immunoglobulin E (IgE) and 25-hydroxyvitamin D, and skin prick test results of the groups were noted. A total of 129 patients fulfilling the necessary criteria were enrolled. The median serum 25-hydroxyvitamin D levels in the study group were significantly lower compared to the control group (P= .014). In the study group, median serum vitamin D levels were significantly higher in men, compared to women (P= .03). There was a significant negative correlation between IgE and vitamin D levels in the allergic rhinitis group (P= .028,r= -0.246). This study showed that patients with allergic rhinitis might be more vulnerable to have lower serum levels of vitamin D. Thus, vitamin D supplementation as an adjunctive therapy may be considered in those patients.
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    Effect of Body Mass Index on Middle Ear Resonance Frequency
    (2018) Sozen, Miray; Oz, Isilay; Erbek, Selim; 29460823
    OBJECTIVE: Multifrequency tympanometry (MET) analyzes tympanograms obtained using different probe tones between 226 and 2000 Hz. An important parameter of MET is resonance frequency (RF). Studies have recently demonstrated that the RF value can vary depending on many factors. To provide new data regarding MET, middle ear RF values were investigated with regard to body mass index (BMI). MATERIALS and METHODS:This study included 78 volunteers (i.e., 156 ears) aged 18-40 years who did not have healing loss and whose otoscopic examinations were normal. Hearing thresholds were measured using pule tone audiometry, and RF values were recorded with immitansmetric measurements. The participants were divided into the following three groups according to their BMI: <18.5 kg/m2, Group 1; 18.5-24.9 kg/m(2), Group 2; and >25 kg/m(2), Group 3. The RE values were also analyzed. RESULTS: Although there was no significant difference between Groups 1 and 2 in terms of RF values, a significant difference was observed between Groups 1 and 3 and between Groups 2 and 3. CONCLUSION: In the light of these data, BMI values should be considered when middle ear RF values are assessed.