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Author: search.filters.author.Kocum, Ismail CengizSubject: search.filters.subject.nanoparticles

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    Design and Construction of Affordable and Domestic Device for Carbon Nanoparticle Synthesis
    (2018) Aykutlu, Dilara; Okursoy, Berkay; Kocum, Ismail Cengiz; Cokeliler Serdaroglu, Dilek
    Nanoparticles are structures below 100 nanometer and used for molecular imaging with gene therapy, implementation of many biomedical applications such as biosensor, cancer-pathology diagnosis and treatment, targeted drug-making and therefore superior in application areas. The aim of the study is to develop a device that synthesizes carbon nanoparticles by dense medium plasma method; together with hardware, software and mechanical design. Dense medium plasma is an easy synthesis approach with low cost; However, it is necessary for the user of this device to be more comfortable to use, feasible, portable and suitable for market. Moreover there is no commercial device for synthesing carbon nanoparticles by dense medium plasma technique. This research presents details of construction of affordable device for carbon nanoparticle sythesis. Prototype is an unique domestic product and contains integrated hardware, software and mechanical probe parts. Hardware part consists of control, power unit and induction coil unit and these three units are connected to each other. The power unit ensures that the mosfets are triggered by a certain voltage from the control unit. The induction coil unit is induced by turning the low voltage to high voltage. In the mechanical part, probe design supplies discharge betweeen electodes which are fed by argon gase that converts benzene to the carbon nanoparticles. The probe reaches the resonance frequency and to make it easier to adjust the distance between the bottom and top electrode, a spindle system is used. Software operation is measuring high voltage. To make the appliance portable, moreover wheeled table production was done. As a result, signal and power card tests were made, it was observed that the high voltage circuit, the signal circuit and the induction coil cause radiation. More nanoparticle production was achieved with the controllable distance between the bottom electrode and the top electrode of probe. The efficiency of the synthesis was improved and the usage of the device was made practical. Finally prototype device that is usable for synthesis nanoparticles by dense medium technology is constructed affordablity and presented with all details.
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    Penetration Depth in Nanoparticles Incorporated Radiofrequency Hyperthermia into the Tissue: Comprehensive Study with Histology and Pathology Observations
    (2019) Nasseri, Behzad; Kocum, Ismail Cengiz; Seymen, Cemile Merve; Rebiee, Navid; 31432798
    In present study, the effective penetration of radiofrequency (RF) induced gold decorated iron oxide nanoparticles (GS@IONPs) hyperthermia was investigated. The effective penetration depth of RF also the damage potency of hyperthermia was evaluated during histopathology observations which were done on the chicken breast tissue and hepatocellular carcinoma (HCC) models. The thermal damages are well- documented in our previous cellular study which was engaged with potency of RF hyperthermia in Epithelial adenocarcinoma (MCF-7) and fibroblast (L-929) cells deaths [1]. In recent work, PEGylated iron oxide nanoparticles (IONPs) were used as base platform for gold magnetic nanoparticles (GS@IONPs) formation. The 144.00015 MHz, 180W RF generator was applied for stimulating the nanoparticles. The chicken breast tissue and the hepatocellular tumor model was considered in the experimental section. In histology studies, the structural changes also the effective penetration depth of RF induced nanoparticles was observed through microscopic monitoring of the tissue slices in histology observations (Gazi medical school). The highest damage level was seen in 8.0 mu m tissue slices where lower damages were seen in depth of 1.0 cm and more inside tissue. The histology observations clarified the effective penetration depth of RF waves and irreversible damages in the 2.0 cm inside the tissue.