Fakülteler / Faculties
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Item An In Vivo Comparison of Commonly Used Topical Antimicrobials on Skin Graft Healing After Full-Thickness Burn Injury(2015) Abbas, Ozan L.; Borman, Huseyin; Bahar, Taner; Ertas, Nilgun M.; Haberal, Mehmet; 0000-0002-3462-7632; 24823344; AAJ-8097-2021Topical antimicrobials are frequently used for local control of infections in burn patients. It has been postulated that these agents retard wound healing. There are limited data about the effects of topical antimicrobial agents on skin graft healing. In this study, we aimed to evaluate the effects of nitrofurazone, 1% silver sulfadiazine, and povidone-iodine on skin graft healing. Forty male rats were used in this study. A meshed skin graft, placed on an excised burn wound, was used as a model to compare topical agents with a control group. Skin graft survival rates, closure of meshed graft interstices (based on physical parameters, namely epithelialization and wound contraction), and histological changes were analyzed. Graft take was more than 85% in all groups. There was no difference between the mean values of the percent graft survival for each group (P > .05). Epithelialization occurred significantly earlier in animals in the nitrofurazone group (P < .05). There was no significant difference between groups in wound contraction rates (P >.05). There was no histological difference between the biopsy specimens of skin grafts. In specimens obtained from the interstices of the meshed graft, no significant differences were found among the groups regarding the wound healing parameters (P > .05). We found that nitrofurazone, silver sulfadiazine, and povidone-iodine had no negative effect on graft healing and take in noncontaminated burn wounds.Item A Practical Cleft Palate Training Model(2020) Ozkan, Burak; Cologlu, Harun; Uysal, Cagri A.; Ertas, Nilgun M.; 0000-0003-3093-8369; 0000-0001-6236-0050; 32309100; AAI-5063-2020; AAJ-2949-2021Educational models are essential for training surgeons and making them familiar with experience- and skill-dependent operations such as cleft palate closure. The development of computer and 3D printer technology has allowed cleft lip and palate models to be produced and used for surgical training. However, these technology-dependent models are not affordable and reproducible for surgeons in developing countries where cleft cases are more commonly seen. Thus, we aimed to create a cleft palate educational model prepared with play-dough and latex. The play-dough is shaped in the form of a palate and the cleft is created by scissors. Then, a latex glove is cut and applied to the dough to mimic the mucosal layer. The combination of the latex glove and play-dough lets the trainee perform surgical markings, incisions, elevation of the flaps, and layer closure. We think this easily producible model might be beneficial for demonstrating cleft types, surgical techniques, and improving surgical skills, especially in developing countries.Item Sacrifice feast disease: Orf(2020) Ozkan, Burak; Uysal, Cagri A.; Uner, Halit; Ertas, Nilgun M.; 0000-0003-3093-8369; 0000-0001-6236-0050; AAI-5063-2020; AAJ-2949-2021Orf disease is a zoonotic infectious caused by parapox virus transmitted by contaminated meat that entered from the disrupted skin. It is usually seen in butchers, farmers, or people who have contact with meat of infected animals commonly in sacrifice feast in Muslim countries. Two patients who admitted to our clinic with orf disease after sacrifice feast were presented. Orf disease should be considered, especially in sacrifice feast term in our country. It heals uneventfully and unnecessary manipulations should be avoided.Item Does methylene blue increases capsular contracture in immediate breast reconstruction with silicone implant? An experimental study(2020) Albayati, Abbas; Ozkan, Burak; Atilgan, Alev O.; Sencelikel, Tugce; Uysal, Cagri A.; Ertas, Nilgun M.; 0000-0003-2806-3006; 0000-0001-8595-8880; 0000-0001-6236-0050; 0000-0003-3093-8369; 33030384; AAC-3344-2021; AAK-3333-2021; AAJ-2949-2021Recently, most of the immediate breast reconstructions following mastectomy are being carried out with the use of silicone implants. In these patients, methylene blue is being used for the detection of sentinel lymph nodes. This experimental study was performed to determine the effect of methylene blue on capsular contracture around breast implants. Thirty-two Sprague Dawley rats were divided into 4 groups. Custom made silicone blocks were placed on the back of animals. In group 1, the incision was closed without performing any additional procedure. In group 2 (control), 0.1 mL of 0.9% normal saline was instilled into the pocket. Group 3 and 4 (study groups) received 0.1 and 0.2 mL of 1% methylene blue, respectively. On postoperative day 60, implants and capsular tissue were extracted. Capsule formation was evaluated both macroscopically and microscopically. The histological evaluation included capsule thickness, inflammation, neovascularization, and fibrosis gradients. Regarding capsule thickness, there were statistically significant differences between groups 1-3, 1-4, 2-3, and 2-4. Although there were more moderate and severe inflammation gradients in groups III and IV, there was no significant difference regarding inflammation severity between control and study groups. In respect of vascular proliferation, there was a statistically significant difference between control and study groups. Similarly, fibrosis gradients were higher in both groups 3 and 4. The study showed that the injection of methylene blue around silicone implants enhanced the formation of capsular contracture. In this case, the degree of contracture was independent of the dose given.Item A Custom-Made Nostril Retainer for Adult Population(2020) Ozkan, Burak; Albayati, Abbas; Akinci, Kadri; Uysal, Cagri A.; Ertas, Nilgun M.; 0000-0001-6236-0050; 32371700Elongation of the stylohyoid process or calcification of the stylohyoid ligament is known as the Eagle syndrome. Mostly, it is seen incidentally on imaging or with extreme suspicion and usually patients are asymptomatic. Surgery is the preferred method in symptomatic patients. Transcervical or transoral methods may be preferred as surgical route. A 28-year-old female patient who had formerly underwent tonsillectomy presented with throat and ear pain. A neck computed tomography was performed, and the patient was diagnosed as Eagle Syndrome. Surgery was recommended. Patient developed transient velopharyngeal insufficiency on postoperative day 4. Ventilation exercise and follow-up was recommended. Complaints of the patient decreased on the 15th day. It should be kept in mind that stylohyoid ligament may be calcified in young age group and middle age group patients with dysphagia or odynophagia, and differential diagnosis should be performed. Another issue is the condition of velofaringeal insufficiency which may occur due to the damage of the pharynx muscles by deep dissection during surgery.