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Author: search.filters.author.Erbek, Selimsearch.filters.applied.f.rights: search.filters.rights.info:eu-repo/semantics/openAccess

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    Role of Single Nucleotide Polymorphisms of Mammaglobin-A Gene in Nasal Polyposis: A Case Control Study
    (2020) Oz, Isilay; Ozdas, Sibel; Bastimur, Sibel; Ozdas, Talih; Muz, Sami Engin; Atilla, Huntuk; Kurt, Kenan; Erbek, Selim; 0000-0003-4825-3499; 0000-0002-7380-4566; B-7604-2019; AAJ-1452-2021
    Objective: Nasal Polyposis (NP) is a chronic inflammatory disease and genetic factors play an important role in the pathophysiology. Mammaglobin-A (MGA) gene expression was significantly higher in patients with NP and chronic rhinosinusitis compared to normal mucosa. In the present study, we investigated the relationship between single nucleotide polymorphisms (SNPs) in the MGA gene and nasal polyposis in the Turkish population. Materials and Methods: A total of 87 patients diagnosed with NP and 60 healthy volunteers were enrolled in the study. Genotypes of MGA promoter SNPs c38C>G, c.21C>T, c55+186G>A and c.243+230A>T were determined by light SNP ASSAY after real time PCR analysis using genomic DNA samples obtained from the peripheral blood samples of all participants. Results: A total of 87 NP patients, 51 male and 36 female, with a mean age of 38.18 +/- 9.5 years were included in the study. No significant difference was determined at all positions c38C>G, c.21C>T, c55+186G>A and c.243+230A>T in nasal polyp patients compared to controls with and without allergic rhinitis (AR). Conclusion: MGA gene c38C>G, c.21C>T, c55 + 186G>A, and c.243 + 230A>T genotypes did not appear to be associated with susceptibility to NP with and without AR in our study population.
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    Comparison of Acoustic and Stroboscopic Findings and Voice Handicap Index between Allergic Rhinitis Patients and Controls
    (2014) Koc, Eltaf Ozbal; Koc, Bulent; Erbek, Selim; 25667789
    Background: In our experience Allergic Rhinitis (AR) patients suffer from voice problems more than health subjects. Aims: To investigate the acoustic analysis of voice, stroscopic findings of larynx and Voice Handicap Index scores in allergic rhinitis patients compared with healthy controls. Study Design: Case-control study. Methods: Thirty adult patients diagnosed with perennial allergic rhinitis were compared with 30 age-and sex-matched healthy controls without allergy. All assessments were performed in the speech physiology laboratory and the testing sequence was as follows: 1. Voice Handicap Index (VHI) questionnaire, 2. Laryngovideostroboscopy, 3. Acoustic analyses. Results: No difference was observed between the allergic rhinitis and control groups regarding mean Maximum Phonation Time (MPT) values, Fo values, and stroboscopic assessment (p>0.05). On the other hand, mean VHI score (p=0.001) and s/z ratio (p=0.011) were significantly higher in the allergic rhinitis group than in controls. Conclusion: Our findings suggest that the presence of allergies could have effects on laryngeal dysfunction and voice-related quality of life.
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    Effect of Body Mass Index on Middle Ear Resonance Frequency
    (2018) Sozen, Miray; Oz, Isilay; Erbek, Selim; 29460823
    OBJECTIVE: Multifrequency tympanometry (MET) analyzes tympanograms obtained using different probe tones between 226 and 2000 Hz. An important parameter of MET is resonance frequency (RF). Studies have recently demonstrated that the RF value can vary depending on many factors. To provide new data regarding MET, middle ear RF values were investigated with regard to body mass index (BMI). MATERIALS and METHODS:This study included 78 volunteers (i.e., 156 ears) aged 18-40 years who did not have healing loss and whose otoscopic examinations were normal. Hearing thresholds were measured using pule tone audiometry, and RF values were recorded with immitansmetric measurements. The participants were divided into the following three groups according to their BMI: <18.5 kg/m2, Group 1; 18.5-24.9 kg/m(2), Group 2; and >25 kg/m(2), Group 3. The RE values were also analyzed. RESULTS: Although there was no significant difference between Groups 1 and 2 in terms of RF values, a significant difference was observed between Groups 1 and 3 and between Groups 2 and 3. CONCLUSION: In the light of these data, BMI values should be considered when middle ear RF values are assessed.