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Author: search.filters.author.Erbek, Hatice SeyraHas files: No

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    The Protective Effect of Metformin Against the Noise-Induced Hearing Loss
    (2018) Kesici, Gulin Gokcen; Ocal, Fatma Ceyda Akin; Gurgen, Seren Gulsen; Erdem, Saban Remzi; Ogus, Ersin; Erbek, Hatice Seyra; Ozluoglu, Levent Naci; 0000-0003-0409-6225; 0000-0002-7537-2170; 0000-0002-9877-421X; 0000-0002-2150-0237; 30306316; AAT-2326-2021; AAJ-2370-2021; AAJ-1058-2021; AAI-8020-2021
    ObjectiveTo test the protective effect of metformin against noise-induced hearing loss.Methods24 rats were included in the study. The first group was exposed to noise only, the second group took metformin, the third group was exposed to noise and took metformin, and the fourth group was neither exposed to noise nor took metformin as control group. After measurement of baseline DPOAE and ABR of rats, the metformin group and the metformin+noise group received 300mg/kg/day metformin via gavage for 10days. On the 11th day, group 1 and group 3 were exposured to white noise at 105dB SPL for 15h. After noise exposure, DPOAE and ABR measurements of all rats were repeated on days 1st, 7th, and 21st. At the end of the study, all animals were sacrificed and cochlear tissues were separated for immunohistochemical assessments.ResultsABR threshold values and DPAOE measurements of groups 1 and 3 were deteriorated on the 1st day after noise, while deterioration in group 1 continued on 7th and 21st days, but normalized on 7th day in group 3. After immune staining, a significant immunoreaction was observed in the noise group, while the reaction in the noise+metformin group was close to the control group.ConclusionMetformin has a protective effect on noise-induced hearing loss in rats. As a conclusion, it is determined that metformin protects from permanent threshold shift in rats. It can be considered a good alternative for protecting noise-induced hearing loss.
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    The Relationship Between Functional Head Impulse Test And Age In Healthy Individuals
    (2022) Emekci, Tugba; Erbek, Hatice Seyra; 34120922
    BACKGROUND: fHIT is an easily applicable test battery that indirectly evaluates the vestibulo-ocular reflex (VOR) from a functional perspective. AIMS/OBJECTIVES: The aim of this study was to Individuals determine the correlation between age and the percentage of correct answers (%CA) obtained in the functional head impulse test (fHIT) in healthy individuals. MATERIAL AND METHODS: A total of 105 volunteers, 50 males and 55 females, between the ages of 18 and 70 years, participated in the study. A Beon Solution fHIT system (Zero Branco (TV), Italy) was used in the study. RESULTS: In our study, a decrease in the mean %CA was observed in all semicircular canals (SCCs) with increasing age. Between age and mean %CA, a significant negative moderate (-0.311) correlation was observed in lateral SCCs, and a significant negative low (-0.257) correlation was observed in posterior SCCs (p < 0.05). In anterior SCCs, there was no statistically significant relationship between age and mean %CA (p > 0.05). CONCLUSIONS: The present study performed in a healthy population will be helpful in terms of making comparisons in studies to be conducted in various vestibular diseases. It will also be a guide for identifying pathological consequences in vestibular diseases.