Fakülteler / Faculties

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Author: search.filters.author.Ciftci, OzgurSubject: search.filters.subject.DISEASE

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    Coronary Flow Velocity Reserve in Burn Injury: A Prospective Clinical Cohort Study
    (2016) Caliskan, Mustafa; Turk, Emin; Karagulle, Erdal; Ciftci, Ozgur; Oguz, Hakan; Kostek, Osman; Moray, Gokhan; Haberal, Mehmet; 0000-0002-3462-7632; 0000-0003-2498-7287; 0000-0002-8522-4956; 0000-0002-1901-5603; 0000-0003-4766-3373; 26284645; AAJ-8097-2021; AAE-1041-2021; C-6247-2017; AAA-3604-2019; AAJ-5609-2021
    The authors sought to evaluate coronary microvascular function and left ventricular diastolic dysfunction using transthoracic Doppler echocardiography in burn patients. In this study, 32 adult burn patients with partial or full-thickness scald burns that were hospitalized and treated were included. The control group was matched for age and sex and was composed of otherwise healthy volunteers. Transthoracic Doppler echocardiography examinations and simultaneous laboratory tests for cardiac evaluation were performed on the sixth month after burn injury as well as with the control group. High-sensitivity C-reactive protein levels were significantly higher in the burn patients than in controls (5.17 +/- 3.86 vs 2.42 +/- 1.78; P =.001). Lateral isovolumic relaxation time was significantly higher in the burn injury group than in the control group (92.7 +/- 15.7 vs 85.5 +/- 8.3; P =.03). Baseline coronary diastolic peak flow velocity of the left anterior descending artery was similar in both groups. However, hyperemic diastolic peak flow velocity and coronary flow velocity reserve (2.26 +/- 0.48 vs 2.94 +/- 0.47; P <.001) were significantly lower in the burn injury group than in the control group. Coronary flow velocity reserve was significantly and inversely correlated with high-sensitivity C-reactive protein, burn ratio, creatinine, and mitral A-wave max velocity. At the sixth month of treatment, burn patients had high-sensitivity C-reactive protein levels during this period, suggesting that inflammation still exists. In addition, subclinical coronary microvascular and left ventricular diastolic dysfunction can occur in burn patients without traditional cardiovascular risk factors. However, these results must be supported by additional studies.
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    Comparison of Platelet Mass Index in On-Pump and Off-Pump Coronary Artery Bypass Surgery
    (2020) Gunday, Murat; Ciftci, Ozgur; 32364905
    Introduction: Platelet mass index (PMI) is calculated by multiplying platelet count and mean platelet volume (MPV). It demonstrates platelet activation and is thought to be associated with inflammation. Its importance for cardiac surgery has not yet fully been clarified. This study investigates whether there is a difference between PMI levels after on-pump and off-pump coronary artery bypass surgery and the relationship between early postoperative complications and PMI. Method: In our hospital, 138 patients were included in the study retrospectively. The patients were divided into 2 groups: Group 1 (on-pump) with 80 patients (22 females, 58 males, mean age 61.54 +/- 8.68) and Group 2 (off-pump) with 58 patients (15 females, 43 males, mean age 61.34 +/- 10.04). In biochemical analysis, hemoglobin, platelet, white blood cell, and MPV values of the patients were evaluated in the biochemistry laboratory of our hospital with the blood taken preoperatively from the forearm veins and postoperatively on the first, third, and seventh days and, on average, after the first month. Results: There was a statistically significant difference between postoperative first day thrombocyte (K/mu L) (P = .005), postoperative first day PMI (P = .014), postoperative first day leukocyte (K/mu L) (P = .001), postoperative first day Hb (g/dL) (P = .001), postoperative third day thrombocyte (K/mu L) (P = .003), postoperative third day PMI (P = .031), postoperative third day leukocyte (K/mu L) (P = .004), and postoperative seventh day leukocyte (K/mu L) (P = .002). There was no meaningful relationship between PMI and early postoperative complications. Conclusion: We think PMI is a more valuable indicator than MPV as an inflammation marker in cardiac surgery. In our opinion, PMI is a cheap and valuable inflammation marker that can be used in coronary surgery that can be obtained from routine hemogram test and can easily be evaluated.