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Author: search.filters.author.Atilgan, Alev OkHas files: Yes

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    In Vivo Study of The Role of Hyaluronic Acid, N-Acetyl Cysteine, and Deproteinized Calf Serum on Injury-Induced Cartilage Degeneration
    (2023) Ozdemir, Mahmut; Birinci, Baris; Haberal, Bahtiyar; Atilgan, Alev Ok; Demirkale, Ismail; https://orcid.org/0000-0003-2674-9549; https://orcid.org/0000-0002-1668-6997; https://orcid.org/0000-0001-8595-8880; 36700278; HOH-2091-2023; W-9080-2019; AAK-3333-2021
    Objectives: The aim of this study was to compare the effects of hyaluronic acid ( HA), N-acetyl cysteine ( NAC), and deproteinized calf serum on cartilage healing after the creation of traumatic cartilage injury in a rat model. Materials and methods: A total of 48 rats, each weighing an average of 350 g, were randomly separated into four groups of 12. An osteochondral defect was created, 2-mm-wide and 3-mm deep in each rat. Injections were made to the knees of the rats as saline solution in Group 1, deproteinized calf serum in Group 2, NAC in Group 3, and HA in Group 4. At the end of 12 weeks, all rats were sacrificed and tissues were evaluated histologically. Results: The HA group had a better cell morphology, tissue morphology, surface architecture, and vascularity than the other groups (p < 0.001). Matrix staining, chondrocyte clustering, and the assessment scores of the mid, deep, superficial zones, and overall were higher in the HA group than in the other groups (p < 0.001). The NAC showed a better tissue morphology, cell morphology, and vascularity than the control group (p= 0.003, p < 0.001, and p < 0.001, respectively). Conclusion: Hyaluronic acid was the most effective agent in cartilage healing compared to NAC and deproteinized calf serum. In addition, the NAC was more effective compared to the control group.
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    Intraosseous angiolipoma of the frontal bone with a unique location: A clinical and pathological case illustration and review of the literature
    (2014) Atilgan, Alev Ok; Terzi, Aysen; Agildere, Muhtesem; Caner, Hakan; Ozdemir, B. Handan
    Here, we report a case of a 16-year-old female patient was referred with scalp swelling and headache. Her neurological examination was normal and imaging of the skull revealed a well-defined lytic lesion measuring 15 mm x 6 mm to the right of the frontal bone. She was operated on with a prediagnosis of Langerhans cell histiocytosis. A wide excision with negative margins was made and the defect was reconstructed with a titanium plate. Subsequently, the lesion was histopathologically diagnosed as an angiolipoma of the frontal bone. The postoperative period was uneventful and she remained well during 1-year follow-up with no evidence of recurrence. Angiolipomas are rare benign lipomatous lesions located mostly in subcutaneous tissue of the forearm or trunk and frequently occur before puberty or in young adults. They are not common in bones. To the best of our knowledge, this is the first angiolipoma of the frontal bone reported.