Fakülteler / Faculties

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Author: search.filters.author.Akkaya, Hamparsearch.filters.applied.f.rights: search.filters.rights.info:eu-repo/semantics/openAccess

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    Primary Leiomyosarcoma of the Kidney: Four Cases
    (2015) Akkaya, Bahar; Tuncer, Saniye Sevim; Akkaya, Hampar; Gurer, Elif Inanc; Baykara, Mehmet
    Renal sarcomas are rare tumors. They constitute only 1-2% of malignant renal tumors in adulthood. Leiomyosarcoma is the most common histological type of renal sarcoma (50-60%). Renal leiomyosarcomas are aggressive tumors arising from the renal capsule, renal vein, pelvic musculature or the renal parenchyma. Diagnosis is usually post operative and requires a thorough sampling of the tumor to rule out an epithelial component. We report 4 new cases of primary renal leiomyosarcomas. Typical morphologic pattern shows alternating fascicles of spindle cells with blunt-ended, non-tapering nuclei and eosinophilic cytoplasm. Nuclear pleomprphisim atypia, mitotic figures and necrosis are seen in different ratios. Immunohistochemically the tumor cells of leiomyosarcoma are positive for SMA, desmin, calponin and h-caldesmon and negative for CK, S-100, HMB-45 and CD117. These tumors are classified using the French Federation of Cancer Centers System. To make a diagnosis of a primary renal sarcoma the following criteria should be met: 1) The patient must not have a sarcoma elsewhere to rule out metastasis. 2) Gross must be compatible with origin in the kidney rather than involvement due to retroperitoneal sarcoma. 3) Sarcomatoid renal cell carcinoma must be excluded. They usually have poor prognosis. But small size (<5 cm), low histological grade, absence of lymph node metastases and radical operations are all associated with better prognosis. Despite radical nephrectomy the tumors can run an aggressive clinical course and early local and distant recurrences are common.
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    Villous Adenoma Coexisting with Non-Muscle Invasive Urothelial Carcinoma of the Bladder, Case Report
    (2015) Akkaya, Bahar; Tasova-Yilmaz, Gulden; Akkaya, Hampar; Usta, Mustafa Faruk
    Occurrence of villous adenomas arising in the urinary tract is uncommon. They have been reported usually in the gastrointestinal tract. We reported a case of urinary bladder villous adenoma coexisting with urothelial carcinoma in a 72-year-old male. The patient underwent trans urethral resection because of diagnosis villous adenoma and non-muscle invasive urothelial carcinoma. Over the past twenty-nine months of follow up, the patient is alive and developed no metastasis. Patients with isolated villous adenomas in the urinary bladder have an excellent prognosis and surgical resection is curative. However, it is uncertain whether an untreated lesion might eventually develop into an adenocarcinoma. Therefore, close follow up is recommended because of the possibility that this condition might be premalignant.
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    Metachronous Occurrence of Granular Cell Tumor in Breast Skin and Scalp: Diagnostic Challenging Differentiating Benign from Malignant and a Literature Review
    (2016) Akkaya, Hampar; Toru, Havva Serap; Ayva, Ebru Sebnem; Karabulut, Zulfikar; Durusoy, Cicek; 26881167
    Granular cell tumor (GCT) is a Schwann cell related benign neoplasm of soft tissue. GCT is an uncommon entity that occurs in a wide variety of body sites, but it is generally presented in the skin, oral cavity, superficial soft tissue, and respiratory and digestive tracts. Most of the GCTs are benign but clinically and radiologically these may mimic malignancy. Histopathological diagnosis is gold standard for establishing the true nature of the lesion. GCT is most commonly solitary but in about 10% of cases can be multifocal, usually involving various skin and soft tissue sites versus involving various internal sites. Therefore, these can involve skin and soft tissue or submucosa and viscera. GCT is usually benign; however, local recurrence is common due to incomplete removal. Malignant cases are rarely reported in 1-2% of cases. In this study, we report clinical and histopathological findings of a 36-year-old woman with metachronous GCT in breast and scalp. The clinical features raise the question of whether these are metachronous benign GCTs or whether this is establishment of malignant behavior. The aim of this report is to present the histopathological and clinical features of GCT and the diagnostic challenge of differentiating benign from malignant GCT.
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    Shrinkage of Nasal Mucosa and Cartilage During Formalin Fixation
    (2017) Kansu, Leyla; Aydin, Erdinc; Akkaya, Hampar; Avci, Suat; Akalin, Nalan; 0000-0003-1707-7760; 0000-0001-6864-7378; 0000-0003-2155-8014; 0000-0002-7070-6901; 28552840; H-8232-2013; AAJ-2379-2021; ABG-2028-2020; O-3636-2018
    Background: After resection, specimens are subjected to formalin fixation during histological processing. This procedure can result in tissue shrinkage, with the amount of shrinkage related to tissue composition and tissue type. Aims: To evaluate the shrinkage of nasal mucosa and cartilage tissue and compare differences in shrinkage after resection, after formalin fixation, and during microscopic examination to understand differences in the rate of shrinkage of different tissue types. Study Design: Animal experimentation. Methods: Fresh nasal septa were excised from sheep (10 mm diameter in 40 sheep and 20 mm diameter in 40 sheep). The mucosa was separated from one side of the cartilage, with the contralateral mucosa remaining attached to the cartilage. Specimen diameters were measured in situ, after resection, after fixation for 6 or 24 hours (10% formalin), and during microscopic examination. Results: There were no differences between the in situ and after resection diameters of any tissue components (free mucosa, mucosa attached to cartilage, and cartilage) of all nasal specimens (10-or 20-mm diameter and 6or 24-hour fixation). However, significant shrinkage occurred between resection and after-fixation. Regarding tissue specimens that were fixed for different durations (6 or 24 hours), we observed a significantly smaller mean tissue diameter in specimens fixed for 24 hours versus those fixed for 6 hours for mucosa attached to cartilage (in the 10-mm diameter after-fixation samples), free mucosa (in the 20-mm diameter after-fixation samples), mucosa attached to cartilage (in the 20-mm diameter after-fixation and microscopic measurement samples), and cartilage (in the 20-mm diameter after-fixation samples). Tissue shrinkage was greatest in free mucosal tissue and least in cartilage. Conclusion: These results should be considered when evaluating patients undergoing surgical procedures for nasal cavity and paranasal sinus malignancies. Surgical margins should be measured before fixation or evaluated if possible before fixation and shrinkage.